Characteristic Deviations of Auditory Evoked Potentials in Individuals with Autism Spectrum Disorder

Abstract Background Neurological, structural, and behavioral abnormalities are widely reported in individuals with autism spectrum disorder (ASD); yet there are no objective markers to date. We postulated that by using dominant and nondominant ear data, underlying differences in auditory evoked potentials (AEPs) between ASD and control groups can be recognized. Purpose The primary purpose was to identify if significant differences exist in AEPs recorded from dominant and nondominant ear stimulation in (1) children with ASD and their matched controls, (2) adults with ASD and their matched controls, and (3) a combined child and adult ASD group and control group. The secondary purpose was to explore the association between the significant findings of this study with those obtained in our previous study that evaluated the effects of auditory training on AEPs in individuals with ASD. Research Design Factorial analysis of variance with interaction was performed. Study Sample Forty subjects with normal hearing between the ages of 9 and 25 years were included. Eleven children and 9 adults with ASD were age- and gender-matched with neurotypical peers. Data Collection and Analysis Auditory brainstem responses (ABRs) and auditory late responses (ALRs) were recorded. Adult and child ASD subjects were compared with non-ASD adult and child control subjects, respectively. The combined child and adult ASD group was compared with the combined child and adult control group. Results No significant differences in ABR latency or amplitude were observed between ASD and control groups. ALR N1 amplitude in the dominant ear was significantly smaller for the ASD adult group compared with their control group. Combined child and adult data showed significantly smaller amplitude for ALR N1 and longer ALR P2 latency in the dominant ear for the ASD group compared with the control group. In our earlier study, the top predictor of behavioral improvement following auditory training was ALR N1 amplitude in the dominant ear. Correspondingly, the ALR N1 amplitude in the dominant ear yielded group differences in the current study. Conclusions ALR peak N1 amplitude is proposed as the most feasible AEP marker in the evaluation of ASD.

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An Exploratory Study of Imagining Sounds and “Hearing” Music in Autism

Journal of Autism and Developmental Disorders ◽

10.1007/s10803-019-04346-w ◽

2019 ◽

Vol 50 (4) ◽

pp. 1123-1132 ◽

Cited By ~ 4

Author(s):

Alex Bacon ◽

C. Philip Beaman ◽

Fang Liu

Keyword(s):

Autism Spectrum Disorder ◽

Exploratory Study ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Auditory Imagery ◽

Typically Developing ◽

And Control ◽

Adults With Asd

AbstractIndividuals with autism spectrum disorder (ASD) reportedly possess preserved or superior music-processing skills compared to their typically developing counterparts. We examined auditory imagery and earworms (tunes that get “stuck” in the head) in adults with ASD and controls. Both groups completed a short earworm questionnaire together with the Bucknell Auditory Imagery Scale. Results showed poorer auditory imagery in the ASD group for all types of auditory imagery. However, the ASD group did not report fewer earworms than matched controls. These data suggest a possible basis in poor auditory imagery for poor prosody in ASD, but also highlight a separability between auditory imagery and control of musical memories. The separability is present in the ASD group but not in typically developing individuals.

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Brainstem auditory evoked potentials in children with autism spectrum disorder

Jornal de Pediatria ◽

10.1016/j.jped.2018.12.010 ◽

2020 ◽

Vol 96 (3) ◽

pp. 386-392

Author(s):

Mariana Keiko Kamita ◽

Liliane Aparecida Fagundes Silva ◽

Fernanda Cristina Leite Magliaro ◽

Rebeca Yuko Couto Kawai ◽

Fernanda Dreux Miranda Fernandes ◽

...

Keyword(s):

Autism Spectrum Disorder ◽

Evoked Potentials ◽

Auditory Evoked Potentials ◽

Children With Autism ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Brainstem Auditory Evoked Potentials

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Semantic Integration Scale to People Diagnosis with Autism Spectrum Disorder

International Journal for Innovation Education and Research ◽

10.31686/ijier.vol8.iss10.2680 ◽

2020 ◽

Vol 8 (10) ◽

pp. 273-285

Author(s):

Ojea Rúa Manuel

Keyword(s):

Autism Spectrum Disorder ◽

Differential Diagnosis ◽

Information Processing ◽

Autism Spectrum ◽

Semantic Integration ◽

T Test ◽

Spectrum Disorder ◽

Control Group ◽

Differential Analysis ◽

And Control

This study's basic aim is evaluating the Semantic Integration Scale (SIS) to give a specific complementary differential instrument in relation to information processing shape of people with autism spectrum disorder (ASD) and, therefore, facilitate the differential diagnosis of people with ASD regarding normotypic people. A total of 376 participants have been selected between 10 and 16 age, distributed in 2 groups, 1 experimental groups formed of people with ASD= 156 and 1 normotypical control group, composed by 220 participants. The conclusive differential analysis of the comparative level between experimental and control group, corresponding to 6 subdimensions of SIS, carried out through t-test for 2 independent samples, it´s concluded the comparative data are significantly different between both groups: experimental and control group, which allows deducing the specificity of this Scale like complementary diagnosis adapted to people with ASD.

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Experiences of Dental Care and Dental Anxiety in Adults with Autism Spectrum Disorder

Autism Research and Treatment ◽

10.1155/2014/238764 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 8

Author(s):

My Blomqvist ◽

Göran Dahllöf ◽

Susanne Bejerot

Keyword(s):

Autism Spectrum Disorder ◽

Dental Treatment ◽

Dental Anxiety ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Control Group ◽

Typically Developing ◽

Adults With Autism ◽

Experienced Pain ◽

Adults With Asd

Dental anxiety is associated with previous distressing dental experiences, such as lack of understanding of the dentist intentions, perceptions of uncontrollability and experiences of pain during dental treatment. People with autism spectrum disorder (ASD) are impaired in building flexible predictions and expectations, which is very much needed during a dental visit. The aims of the study were to investigate if people with ASD have more negative dental experiences and a higher level of dental anxiety compared to a matched control group. Forty-seven adults with ASD and of normal intellectual performance, and 69 age- and sex-matched typically developing controls completed questionnaires on previous dental experiences and dental anxiety, the Dental Anxiety Scale, and the Dental Beliefs Survey. The ASD group experienced pain during dental treatments more often than the controls and 22% had repeatedly experienced being forced to dental treatment they were not prepared for, compared to 3% of the controls. A higher level of dental anxiety was reported by the ASD group. Dental treatment and methods for supporting the communication with patients with ASD need to be developed, in order to reduce the negative dental experiences and dental anxiety in people with ASD.

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Minor Physical Anomalies in Adults with Autism Spectrum Disorder and Healthy Controls

Autism Research and Treatment ◽

10.1155/2014/743482 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 8

Author(s):

Irina Manouilenko ◽

Jonna M. Eriksson ◽

Mats B. Humble ◽

Susanne Bejerot

Keyword(s):

Autism Spectrum Disorder ◽

Autistic Traits ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Control Group ◽

Healthy Controls ◽

Adults With Autism ◽

The Individual ◽

Minor Physical Anomalies ◽

Adults With Asd

Minor Physical Anomalies (MPAs) are subtle abnormalities of the head, face, and limbs, without significant cosmetic or functional impact to the individual. They are assumed to represent external markers of developmental deviations during foetal life. MPAs have been suggested to indicate severity in mental illness and constitute external markers for atypical brain development. Higher frequencies of MPAs can be found in children with autism. The aims of the present study were to examine the prevalence and patterns of MPAs in adults with autism spectrum disorder (ASD) and to investigate whether MPAs are associated with symptom severity and overall functioning. Fifty adults with ASD and intelligence within the normal range and 53 healthy controls were examined with the Waldrop scale, an instrument for assessing MPAs. Face and feet were photographed enabling blinded assessment. Significant differences between the ASD and the control group were found on the MPA total scores, and also in the craniofacial region scores. Moreover, the shape of the ears was associated with autistic traits, in the ASD group. High MPA total scores were associated with poorer functioning. The findings suggest a link between MPAs, autistic traits, and level of functioning. Assessment of MPAs may assist in the diagnostic procedure of psychiatric disorders.

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Impacto de la intervención psicomotriz en la comunicación de personas con trastornos del espectro autista: resultados preliminares / Impacts of Physical Treatment in Communicate Skills in Autism Spectrum Disorder: Preliminary Results

Revista Internacional de Educación y Aprendizaje ◽

10.37467/gka-revedu.v4.206 ◽

2016 ◽

Vol 4 (1) ◽

Author(s):

Joanne Mampaso Desbrow ◽

Diana Ruiz Vicente ◽

Juan José Salinero Martín ◽

Ana Seoane Ruiz ◽

Miriam De los Santos López ◽

...

Keyword(s):

Autism Spectrum Disorder ◽

Communication Skills ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Control Groups ◽

Physical Treatment ◽

Preliminary Results ◽

And Control ◽

Los Grupos

ABSTRACTThe study of the treatment in people with TEA (Autism spectrum disorder) has been development for the last few years. In this paper, we reflect how physical treatment and musical support can increase the development of communication skills in a group of 27 subjects diagnosed as TEA. The results show that there are differences between the pilot and control groups with significant evidences improvements in the variables study, qualitative and quantitative.RESUMENEn la actualidad, existen pocos estudios vinculados a la intervención motriz en población con Trastorno del Espectro Autista (TEA) y, menos aún que incluyan como variable relevante de dicha intervención una mejora en el área comunicativa. El objetivo de este estudio, es tratar de analizar en qué medida, a través de una intervención motriz, favorece el desarrollo de las habilidades de comunicación en una población de 27 sujetos diagnosticados como TEA. Los resultados obtenidos muestran que existen diferencias en los grupos control y experimental de forma que, parecen evidenciarse mejoras significativas en las variables estudiadas, desde el punto de vista cualitativo y cuantitativo. Contacto principal: [email protected]

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Brainstem Auditory Evoked Potentials for diagnosing Autism Spectrum Disorder, ADHD and Schizophrenia Spectrum Disorders in adults. A blinded study

Psychiatry Research ◽

10.1016/j.psychres.2017.06.085 ◽

2017 ◽

Vol 257 ◽

pp. 21-26 ◽

Cited By ~ 3

Author(s):

Irina Manouilenko ◽

Mats B. Humble ◽

Jeanette Georgieva ◽

Susanne Bejerot

Keyword(s):

Autism Spectrum Disorder ◽

Evoked Potentials ◽

Auditory Evoked Potentials ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Brainstem Auditory Evoked Potentials ◽

Schizophrenia Spectrum Disorders ◽

Schizophrenia Spectrum ◽

Blinded Study ◽

Spectrum Disorders

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Exclusion Criteria Used in Early Behavioral Intervention Studies for Young Children with Autism Spectrum Disorder

Brain Sciences ◽

10.3390/brainsci10020099 ◽

2020 ◽

Vol 10 (2) ◽

pp. 99

Author(s):

Sahr Yazdani ◽

Angela Capuano ◽

Mohammad Ghaziuddin ◽

Costanza Colombi

Keyword(s):

Autism Spectrum Disorder ◽

Behavioral Intervention ◽

Behavioral Interventions ◽

Intervention Studies ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Control Groups ◽

Exclusion Criteria ◽

Design Studies ◽

And Control

This literature review evaluated early behavioral intervention studies of Autism Spectrum disorder (ASD) based on their participant exclusion criteria. The studies included were found through searching PsycINFO and PubMed databases, and discussed behavioral interventions for children up to 5 years of age with ASD and utilized a group research design. Studies reviewed were categorized into three groups: Restrictive exclusion criteria, loosely defined exclusion criteria, and exclusion criteria not defined. Results indicated that studies that used restrictive exclusion criteria demonstrated greater differences in terms of outcomes between experimental and control groups in comparison to studies that used loosely defined exclusion criteria and/or did not define any exclusion criteria. We discussed implications for the generalizability of the studies’ outcomes in relationship to exclusion criteria.

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Neurobiological mechanisms of social cognition treatment in high-functioning adults with autism spectrum disorder

Psychological Medicine ◽

10.1017/s0033291719002472 ◽

2019 ◽

Vol 50 (14) ◽

pp. 2374-2384 ◽

Cited By ~ 2

Author(s):

Gabriela Rosenblau ◽

Garret O'Connell ◽

Hauke R. Heekeren ◽

Isabel Dziobek

Keyword(s):

Autism Spectrum Disorder ◽

Social Cognitive ◽

Computer Training ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Control Group ◽

Adults With Autism ◽

Control Group Design ◽

Before And After ◽

Adults With Asd

AbstractBackgroundThe promise of precision medicine for autism spectrum disorder (ASD) hinges on developing neuroscience-informed individualized interventions. Taking an important step in this direction, we investigated neuroplasticity in response to an ecologically-valid, computer-based social-cognitive training (SCOTT).MethodsIn an active control group design, 48 adults with ASD were randomly assigned to a 3-month SCOTT or non-social computer training. Participants completed behavioral tasks, a functional and structural magnetic resonance imaging session before and after the training period.ResultsThe SCOTT group showed social-cognitive improvements on close and distant generalization tasks. The improvements scaled with reductions in functional activity and increases in cortical thickness in prefrontal regions.ConclusionIn sum, we provide evidence for the sensitivity of neuroscientific methods to reflect training-induced social-cognitive improvements in adults with ASD. These results encourage the use of neuroimaging data to describe and quantify treatment-related changes more broadly.

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