Abstract
Background: Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by a triad of social, communicative, and imaginative impairments. Although early detection and intervention are important to improve functional outcomes in ASD, similar features between ASD and other developmental delays may impede timely diagnosis. In this study, we aimed to investigate the feasibility of Cognitive Visual Assessment Questionnaire (CVAQ) in differentiating ASD from other developmental delays.Methods: We retrospectively reviewed the medical records of 115 pediatric patients (80 males, 35 females) with ASD and other developmental delays who had the Modified Checklist for Autism in Toddlers (M-CHAT) and CVAQ performed at Uijeongbu St. Mary's Hospital from January 2017 to June 2019. Results: The mean age at M-CHAT and CVAQ was 31.8 months (range, 14.1 – 48). The proportion of ASD was significantly higher in patients with screen-positive M-CHAT than those with screen-negative M-CHAT (P = 0.035). The sensitivity of CVAQ for detecting ASD was 83.3% and 94.1% in 14.1 – <24 months and 24 – <36 months age groups, respectively. Among patients with screen-negative M-CHAT, the mean number of failed tasks related to dorsal stream pathway was greater in ASD compared to other developmental delays, although the differences were not statistically significant (P = 0.437).Conclusions: Our study demonstrates that autistic individuals may have a specific impairment in dorsal stream functioning. CVAQ also showed improved sensitivity for detecting ASD in toddlers. When coupled with clinical observation and judgement, CVAQ is a useful alternative screening tool for differentiating ASD from other developmental delays in young children.