In the developing world alone, there are over 200 million children who are in need of immediate early childhood development interventions. Most affected by poor or lack of quality ECD are the poor and those children in low income households. Early childhood development interventions protect children against the effects of poverty, poor nutrition, inadequate healthcare, and a lack of education. Globally, various ECD programme interventions in communities clearly indicate that communities and families want quality ECD programmes for their children at a cost that is affordable. In South Africa, quality early childhood development interventions could have a significant effect in reducing poverty and inequality. This chapter interrogates the challenges and benefits of extending quality ECE & D particularly to disadvantaged and materially deprived children in South African informal settlements. The chapter is based empirical research as well as secondary data in the form of books, book chapters, and accredited journals.