scholarly journals The Val66Met Polymorphism at the BDNF Gene does not Influence Wisconsin Card Sorting Test Results in Children and Adolescents with Bipolar Disorder

2013 ◽  
Vol 35 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Cristian Patrick Zeni ◽  
Silzá Tramontina ◽  
Thamis Aline Zeni ◽  
Roberta Coelho ◽  
Gabriel Pheula ◽  
...  
2009 ◽  
Vol 31 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Juliana Fernandes Tramontina ◽  
Denise Yates ◽  
Pedro Vieira da Silva Magalhães ◽  
Clarissa Trentini ◽  
Márcia Kauer Sant'Anna ◽  
...  

OBJECTIVE: In the present study, we investigate the association between the val66met polymorphism of the brain-derived neurotrophic factor (BNDF) and the performance on the Wisconsin Card Sorting Test in a sample of Caucasian Brazilian patients with bipolar disorder. METHOD: Sixty-four patients with bipolar disorder were assessed and their performance on the Wisconsin Card Sorting Test was compared with the allele frequency and genotype of the val66met polymorphism of the brain-derived neurotrophic factor. RESULTS: The percentage of non-perseverative errors was significantly higher among patients with the val/val genotype. There was no association between (BNDF) genotype frequency and other Wisconsin Card Sorting Test domains. CONCLUSION: Our results did not replicate previous descriptions of an association between a worse cognitive performance and the presence of the met allele of the val66met brain-derived neurotrophic factor gene polymorphism.


2011 ◽  
Vol 21 ◽  
pp. S171-S172
Author(s):  
A. Slopien ◽  
M. Dmitrzak-Weglarz ◽  
A.R. Borkowska ◽  
F. Rybakowski ◽  
M. Witkowska ◽  
...  

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