Neoplastic Meningitis and Paraneoplastic Syndromes

Approximately 20% of renal cell carcinoma (RCC) is diagnosed because of paraneoplastic manifestations. RCC has been associated with a large variety of paraneoplastic syndromes (PNS), but it is rarely associated with PNS vasculitis. We present a case of a previously healthy male who presented with systemic vasculitis; bitemporal headaches, diplopia, polyarthritis, palpable purpura, tongue lesion, peri-orbital edema, scleritis, chondritis and constitutional symptoms. He was subsequently found to have oligometastatic RCC. Both his primary lesion and site of oligometastasis were treated with stereotactic radiotherapy (SBRT) and resulted in the resolution of his vasculitis, as well as sustained oncologic response. This is the first case to demonstrate that effective sustained treatment for PNS vasculitis due to oligometastatic RCC is possible with SBRT.

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Stiff person syndrome, transverse myelitis and hypothalamitis; three paraneoplastic syndromes associated with occult breast cancer

Acta Neurologica Belgica ◽

10.1007/s13760-020-01570-5 ◽

2021 ◽

Author(s):

Sidonie Ibrikji ◽

Tarek El Halabi ◽

Raja Sawaya ◽

Samir Atweh

Keyword(s):

Breast Cancer ◽

Transverse Myelitis ◽

Paraneoplastic Syndromes ◽

Stiff Person Syndrome ◽

Occult Breast Cancer

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The co-occurrence of leukemoid reaction and hypercalcemia in a patient with endometrial cancer: A case report and literature review

Science Progress ◽

10.1177/00368504211004028 ◽

2021 ◽

Vol 104 (2) ◽

pp. 003685042110040

Author(s):

Weimin Tao ◽

Qin Yan ◽

Yao Zhou ◽

Yanli Wang ◽

Zhiqiang Liu ◽

...

Keyword(s):

Endometrial Cancer ◽

Early Identification ◽

Metabolic Alkalosis ◽

Rare Case ◽

Symptomatic Treatment ◽

Clinical Situation ◽

Paraneoplastic Syndromes ◽

Leukemoid Reaction ◽

Clinical Prognosis ◽

Infection Treatment

Paraneoplastic syndromes are rarely seen in gynecological tumors especially in endometrial cancer. Early identification of paraneoplastic syndromes plays a significant role in the treatment and prognosis of cancer. Here, we reported a rare case with endometrial cancer with a 2.7 cm × 2.2 cm × 3.4 cm lesion in the posterior cervix presenting leukemoid reaction and hypercalcemia as paraneoplastic syndromes simultaneously. During the progress of the endometrial cancer, her leukocyte level rose up to 60.7 × 109/L after anti-infection treatment. Meanwhile, the patient represented a series of severe clinical situation including hypercalcemia, hypokalemia, metabolic alkalosis. and respiratory failure. Finally, the patient died of respiratory circulatory failure 2 weeks later. In addition to symptomatic treatment, possible treatment targeted on the primary tumor as early as possible might help to improve the clinical prognosis.

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