Cross-linking of cellulose and poly(ethylene glycol) with citric acid

2015 ◽  
Vol 90 ◽  
pp. 21-24 ◽  
Author(s):  
Pamela de Cuadro ◽  
Tiina Belt ◽  
Katri S. Kontturi ◽  
Mehedi Reza ◽  
Eero Kontturi ◽  
...  
Keyword(s):  
Citric Acid ◽  
Ethylene Glycol ◽  
Cross Linking ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Water-soluble polyesters from long chain alkylesters of citric acid and poly(ethylene glycol)

2007 ◽  
Vol 43 (4) ◽  
pp. 1288-1301 ◽  
Author(s):  
Fabienne Barroso-Bujans ◽  
Ricardo Martínez ◽  
Mehrdad Yazdani-Pedram ◽  
Pedro Ortiz ◽  
Holger Frey
Keyword(s):  
Citric Acid ◽  
Ethylene Glycol ◽  
Water Soluble ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Long Chain

Preparation and Properties of a Hydrolytically Stable Cyclooctyne-Containing Polymer

Synlett ◽  
2018 ◽  
Vol 29 (19) ◽  
pp. 2535-2541
Author(s):  
Alex Adronov ◽  
Kelvin Li ◽  
Stuart McNelles
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
Monomethyl Ether ◽  
Phenylene Vinylene ◽  
Cross Linking ◽  
Poly Ethylene Glycol ◽  
Ethylene Glycol Monomethyl Ether ◽  
Glycol Monomethyl Ether ◽  
Poly Ethylene

A poly[(phenylene vinylene)-co-dibenzocyclooctyne] polymer prepared by Wittig polymerization chemistry between dibenzocyclooctyne bisaldehyde [DIBO-(CHO)2] and bis(triethyleneglycol)phenylbis(tributylphosphonium) dibromide is reported. The resulting polymer exhibits moderate molecular weight (Mn: 10.5 kDa, Mw: 21.3 kDa, Ð: 2.02) and is fluorescent. It could be readily functionalized by strain-promoted alkyne-azide cycloadditon with different azides, and fluorescence of the polymer was preserved after functionalization. Grafting azide-terminated 5 kDa poly(ethylene glycol) monomethyl ether chains drastically affected the solubility of the polymer. Cross-linking the polymer with poly(ethylene glycol) that was terminated at both ends with azide groups gave access to a fluorescent organogel that could be dried and reswollen with water to form a hydrogel.

scholarly journals rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 855 ◽  
Author(s):  
Weikun Meng ◽  
Ana Rey-Rico ◽  
Mickaël Claudel ◽  
Gertrud Schmitt ◽  
Susanne Speicher-Mentges ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Citric Acid ◽  
Ethylene Glycol ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Monomethyl Ether ◽  
Poly Ethylene Glycol ◽  
Ethylene Glycol Monomethyl Ether ◽  
Glycol Monomethyl Ether ◽  
Poly Ethylene

Scaffold-assisted gene therapy is a highly promising tool to treat articular cartilage lesions upon direct delivery of chondrogenic candidate sequences. The goal of this study was to examine the feasibility and benefits of providing highly chondroreparative agents, the cartilage-specific sex-determining region Y-type high-mobility group 9 (SOX9) transcription factor or the transforming growth factor beta (TGF-β), to human bone marrow-derived mesenchymal stromal cells (hMSCs) via clinically adapted, independent recombinant adeno-associated virus (rAAV) vectors formulated with carbon dots (CDs), a novel class of carbon-dominated nanomaterials. Effective complexation and release of a reporter rAAV-lacZ vector was achieved using four different CDs elaborated from 1-citric acid and pentaethylenehexamine (CD-1); 2-citric acid, poly(ethylene glycol) monomethyl ether (MW 550 Da), and N,N-dimethylethylenediamine (CD-2); 3-citric acid, branched poly(ethylenimine) (MW 600 Da), and poly(ethylene glycol) monomethyl ether (MW 2 kDa) (CD-3); and 4-citric acid and branched poly(ethylenimine) (MW 600 Da) (CD-4), allowing for the genetic modification of hMSCs. Among the nanoparticles, CD-2 showed an optimal ability for rAAV delivery (up to 2.2-fold increase in lacZ expression relative to free vector treatment with 100% cell viability for at least 10 days, the longest time point examined). Administration of therapeutic (SOX9, TGF-β) rAAV vectors in hMSCs via CD-2 led to the effective overexpression of each independent transgene, promoting enhanced cell proliferation (TGF-β) and cartilage matrix deposition (glycosaminoglycans, type-II collagen) for at least 21 days relative to control treatments (CD-2 lacking rAAV or associated to rAAV-lacZ), while advantageously restricting undesirable type-I and -X collagen deposition. These results reveal the potential of CD-guided rAAV gene administration in hMSCs as safe, non-invasive systems for translational strategies to enhance cartilage repair.

Synthesis of Sulfhydryl Cross-Linking Poly(Ethylene Glycol)-Peptides and Glycopeptides as Carriers for Gene Delivery†

2002 ◽  
Vol 13 (2) ◽  
pp. 232-239 ◽  
Author(s):  
Youmie Park ◽  
Kai Y. Kwok ◽  
Chawki Boukarim ◽  
Kevin G. Rice
Keyword(s):  
Gene Delivery ◽  
Ethylene Glycol ◽  
Cross Linking ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Dual mode gelation behavior of silk fibroin microgel embedded poly(ethylene glycol) hydrogels

2016 ◽  
Vol 4 (26) ◽  
pp. 4574-4584 ◽  
Author(s):  
S. Ryu ◽  
H. H. Kim ◽  
Y. H. Park ◽  
C.-C. Lin ◽  
I. C. Um ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Silk Fibroin ◽  
Cross Linking ◽  
Poly Ethylene Glycol ◽  
Dual Mode ◽  
Hydrogel Formation ◽  
Gelation Behavior ◽  
Poly Ethylene

Hydrogel formation by more than two cross-linking mechanisms is preferred for the sophisticated manipulation of hydrogel properties.

Enhancement of Mechanical Properties Upon Hydration in Copolymers of PEG and Iodinated Tyrosine-derived Poycarbonates

2008 ◽  
Vol 1132 ◽  
Author(s):  
F. Bedoui ◽  
L. K. Widjaja ◽  
A. Luk ◽  
D. Bolikal ◽  
N. S. Murthy ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Molecular Weight ◽  
Ethylene Glycol ◽  
Ethyl Ester ◽  
Opposite Effect ◽  
Polymeric Materials ◽  
Cross Linking ◽  
Poly Ethylene Glycol ◽  
Reinforcing Effect ◽  
Poly Ethylene

ABSTRACTIncrease in modulus upon hydration in copolymers of desaminotyrosyl-tyrosine ethyl ester (DTE) and poly(ethylene glycol) (PEG) with iodinated tyrosines, poly(I2DTE-co-PEG carbonate)s, was investigated by varying the fraction and the molecular weight of the hydrophilic PEG component. Water, as expected, acts as plasticizer in polymer with PEG content < 15 wt% and > 30 wt%. But, water has the opposite effect in iodinated polymers with moderate PEG contents, between 15 to 20 wt%: it enhances the Young's modulus. The strength and modulus of hydrated poly(I2DTE-co-15%PEG2K carbonate)s increased by as much as fifteen fold upon hydration. While the decrease in the mechanical properties in most polymeric materials with diluents such water is due to the solvent-induced swelling, the increase in strength and modulus that is observed is most likely due to the reinforcing effect of the increased cross-linking efficiency of the hydrated PEG domains in the iodinated polymer.

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