Inverse age-related changes between hypothalamic NPY and KISS1 gene expression during pubertal initiation in male rhesus monkey

2022 ◽  
Vol 22 (1) ◽  
pp. 100599
Author(s):  
Riffat Bano ◽  
Shazia Shamas ◽  
Saeed ul H. Khan ◽  
Muhammad Shahab
Keyword(s):  
Gene Expression ◽  
Rhesus Monkey ◽  
Age Related ◽  
Male Rhesus ◽  
Age Related Changes

Age-related changes in pancreatic islet cell gene expression

Metabolism ◽  
1995 ◽  
Vol 44 (3) ◽  
pp. 320-324 ◽  
Author(s):  
Stephen J. Giddings ◽  
Lynn R. Carnaghi ◽  
Arshag D. Mooradian
Keyword(s):  
Gene Expression ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Pancreatic Islet Cell ◽  
Age Related ◽  
Cell Gene Expression ◽  
Cell Gene ◽  
Age Related Changes

scholarly journals The Impact of Long‐Term Physical Activity on Age‐Related Changes in Protein and Gene Expression

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Ian R Lanza ◽  
Daniel K Short ◽  
Kevin R Short ◽  
Yan W Asmann ◽  
Sreekumar Raghavakaimal ◽  
...  
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Age Related ◽  
The Impact ◽  
Age Related Changes

Age-related changes in potassium-evoked overflow of dopamine in the striatum of the rhesus monkey

1995 ◽  
Vol 16 (6) ◽  
pp. 939-946 ◽  
Author(s):  
Greg A. Gerhardt ◽  
Wayne A. Cass ◽  
Michael Henson ◽  
Zhiming Zhang ◽  
Aliza Ovadia ◽  
...  
Keyword(s):  
Rhesus Monkey ◽  
Age Related ◽  
Age Related Changes

Age-related changes in the transcriptional profile of mouse RPE/choroid

2003 ◽  
Vol 15 (3) ◽  
pp. 258-262 ◽  
Author(s):  
Hisashi Ida ◽  
Sharon A. Boylan ◽  
Andrea L. Weigel ◽  
Leonard M. Hjelmeland
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Cdna Probe ◽  
Gene Expression Profiles ◽  
Age Related Macular Degeneration ◽  
Pcr Analysis ◽  
Rt Pcr ◽  
Mouse Cdna ◽  
Age Related ◽  
Age Related Changes

To evaluate the age-related changes in gene expression occurring in the complex of retinal pigmented epithelium, Bruch’s membrane, and choroid (RPE/choroid), we examined the gene expression profiles of young adult (2 mo) and old (24 mo) male C57BL/6 mice. cDNA probe sets from individual animals were synthesized using total RNA isolated from the RPE/choroid of each animal. Probes were amplified using the Clontech SMART system, radioactively labeled, and hybridized to two different Clontech Atlas mouse cDNA arrays. From each age group, three independent triplicates were hybridized to the arrays. Statistical analyses were performed using the Significance Analysis of Microarrays program (SAM version 1.13; Stanford University). Selected array results were confirmed by semi-quantitative RT-PCR analysis. Of 2,340 genes represented on the arrays, ∼60% were expressed in young and/or old mouse RPE/choroid. A moderate fraction (12%) of all expressed genes exhibited a statistically significant change in expression with age. Of these 150 genes, all but two, HMG14 and carboxypeptidase E, were upregulated with age. Many of these upregulated genes can be grouped into several broad functional categories: immune response, proteases and protease inhibitors, stress response, and neovascularization. RT-PCR results from six of six genes examined confirmed the differential change in expression with age of these genes. Our study provides likely candidate genes to further study their role in the development of age-related macular degeneration and other aging diseases affecting the RPE/choroid.

cDNA expression arrays reveal incomplete reversal of age-related changes in gene expression by calorie restriction

2000 ◽  
Vol 115 (3) ◽  
pp. 157-174 ◽  
Author(s):  
Eun-Soo Han ◽  
Susan G Hilsenbeck ◽  
Arlan Richardson ◽  
James F Nelson
Keyword(s):  
Gene Expression ◽  
Calorie Restriction ◽  
Expression Arrays ◽  
Cdna Expression ◽  
Age Related ◽  
Age Related Changes

scholarly journals Microarray analysis of aging-associated immune system alterations in the rostral ventrolateral medulla of F344 rats

2017 ◽  
Vol 49 (8) ◽  
pp. 400-415 ◽  
Author(s):  
Sivasai Balivada ◽  
Chanran K. Ganta ◽  
Yongqing Zhang ◽  
Hitesh N. Pawar ◽  
Richard J. Ortiz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Immune System ◽  
Neural Substrates ◽  
Rostral Ventrolateral Medulla ◽  
Ventrolateral Medulla ◽  
Middle Aged ◽  
Transcriptomic Profile ◽  
Age Related ◽  
F344 Rats ◽  
Age Related Changes

The rostral ventrolateral medulla (RVLM) is an area of the brain stem that contains diverse neural substrates that are involved in systems critical for physiological function. There is evidence that aging affects some neural substrates within the RVLM, although age-related changes in RVLM molecular mechanisms are not well established. The goal of the present study was to characterize the transcriptomic profile of the aging RVLM and to test the hypothesis that aging is associated with altered gene expression in the RVLM, with an emphasis on immune system associated gene transcripts. RVLM tissue punches from young, middle-aged, and aged F344 rats were analyzed with Agilent’s whole rat genome microarray. The RVLM gene expression profile varied with age, and an association between chronological age and specific RVLM gene expression patterns was observed [ P < 0.05, false discovery rate (FDR) < 0.3]. Functional analysis of RVLM microarray data via gene ontology profiling and pathway analysis identified upregulation of genes associated with immune- and stress-related responses and downregulation of genes associated with lipid biosynthesis and neurotransmission in aged compared with middle-aged and young rats. Differentially expressed genes associated with the complement system and microglial cells were further validated by quantitative PCR with separate RVLM samples ( P < 0.05, FDR < 0.1). The present results have identified age-related changes in the transcriptomic profile of the RVLM, modifications that may provide the molecular backdrop for understanding age-dependent changes in physiological regulation.

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