Nationwide study of Parkinson's disease incidence between 2010 and 2015 among the French agricultural population

2018 ◽  
Vol 66 ◽  
pp. S264-S265
Author(s):  
F. Moisan ◽  
T. Vlaar ◽  
E. Moutengou ◽  
M. Boussac-Zarebska ◽  
L. Carcaillon-Bentata ◽  
...  
2019 ◽  
Vol 49 (2) ◽  
pp. 435-447 ◽  
Author(s):  
Tamara V Azizova ◽  
Maria V Bannikova ◽  
Evgeniya S Grigoryeva ◽  
Valentina L Rybkina ◽  
Nobuyuki Hamada

Abstract Background Patients receiving radiotherapy demonstrate cognitive deficits, impairment of neurogenesis and neurovascular damage developing as late side effects of radiation exposure to the head. In light of the increasing use of diagnostic radiological procedures, epidemiological data raise concerns about possible harmful effects of low-level radiation on the human brain. A series of studies of chronically exposed Russian nuclear workers have provided information on risks of cancer and non-cancer diseases. Methods This study aimed to assess the risk of Parkinson’s-disease (PD) incidence in a cohort of workers occupationally exposed to chronic radiation. The cohort comprised workers of a Russian nuclear production facility who were first employed in 1948–1982 and followed up until the end of 2013 (22 377 individuals; 25% female). Using the AMFIT module of EPICURE software, relative risk and excess relative risk per unit dose (ERR/Gy) were calculated based on maximum likelihood. Results A linear association was found between PD incidence and cumulative γ-dose after adjusting for sex and attained age [ERR/Gy = 1.02 (95% confidence interval, 0.59 to 1.63, p = 5.44 × 10–5)]. The ERR/Gy of external radiation for PD incidence was stable after adjusting for neutron dose (ERR/Gy = 1.03; 95% confidence interval: 0.59 to 1.67, p = 6.86 × 10–5). The risk increased with increasing lag period and decreased notably after adjusting for body mass index, smoking and alcohol consumption. Additional adjustments for hypertension, gout, gastric ulcer, head injuries with loss of awareness and diabetes mellitus did not affect the risk estimate. Conclusions This study is the first to suggest that PD is associated with prolonged occupational external γ-ray exposure.


2016 ◽  
Vol 96 ◽  
pp. 75-81 ◽  
Author(s):  
Pei-Chen Lee ◽  
Li-Ling Liu ◽  
Yu Sun ◽  
Yu-An Chen ◽  
Chih-Ching Liu ◽  
...  

2013 ◽  
Vol 28 (3) ◽  
pp. 334-340 ◽  
Author(s):  
Richard W. Walker ◽  
Andrew Chaplin ◽  
Rebecca L. Hancock ◽  
Rachel Rutherford ◽  
William K. Gray

2012 ◽  
Vol 18 (5) ◽  
pp. 598-601 ◽  
Author(s):  
O. Riedel ◽  
R. Dodel ◽  
G. Deuschl ◽  
J. Klotsche ◽  
H. Förstl ◽  
...  

2014 ◽  
Vol 22 (3) ◽  
pp. 464-471 ◽  
Author(s):  
P. Blin ◽  
C. Dureau-Pournin ◽  
A. Foubert-Samier ◽  
A. Grolleau ◽  
E. Corbillon ◽  
...  

2019 ◽  
Vol 48 (Supplement_3) ◽  
pp. iii17-iii65
Author(s):  
Colm Byrne ◽  
Kathleen Bennett ◽  
Anne Hickey ◽  
Paul Kavanagh ◽  
Brian Broderick ◽  
...  

Abstract Background Fine particulate matter (PM2.5) has been associated with disease incidence worldwide. In Ireland this is mainly produced by residential heating systems, particularly peat, coal and wood. This study aimed to explore the relationship between short-term exposure to PM2.5 and hospital admissions due to stroke, atrial fibrillation, myocardial infarction, atrial fibrillation (AF), heart failure, chronic obstructive pulmonary disease (COPD), asthma, Parkinson’s disease, dementia and hip fracture in Dublin City and County between 2013 and 2017. Methods This was an ecological time series design utilising routine hospitalisation data collected from the national Health Service Executive (Hospital In-Patient Enquiry (HIPE)). Incidence of hospitalisation for each disease was identified by county of residence. Mean daily PM2.5 levels for Dublin were calculated using monitoring data from the Environmental Protection Agency’s four monitoring sites. Disease incidence was organised by mean PM2.5 levels into 10μg/m3 categories and analysed using Poisson regression models correcting for minimum daily temperature at a lag of zero to five days. Results There was a significant increase in the short-term incidence of acute ischaemic stroke, AF, heart failure, Parkinson’s disease, dementia and COPD when PM2.5 levels were above 50μg/m3 compared to when levels were below 10μg/m3 at one day post exposure when correcting for minimum temperature. Conclusion Controls need to be brought in to ensure that PM2.5 does not exceed a 50μg/m3 level due to the increase in disease incidence associated with same. The urban burning of solid fuels should be severely restricted.


2020 ◽  
pp. oemed-2020-106958
Author(s):  
Xiaoke Zeng ◽  
Nathan L DeBono ◽  
Anne M Harris ◽  
Victoria H Arrandale ◽  
Paul A Demers

ObjectivesWe examined employment in mining occupations and industries and its association with neurological disease incidence in a linkage cohort from Ontario, Canada. Outcomes included Alzheimer’s disease (alone and with other dementias), Parkinson’s disease, parkinsonism, motor neuron disease and amyotrophic lateral sclerosis (ALS).MethodsThe Occupational Disease Surveillance System cohort was created by linking workers’ compensation data and healthcare usage records. This analysis included over 1.1 million male workers, followed between 1999 and 2016. Neurological diseases were ascertained using physician billing and hospital discharge records. Adjusted Poisson regression models were used to estimate incidence rate ratios (RR) comparing mining to non-mining workers overall and by ore (industry) and occupation group.ResultsSuggested elevations in incidence rates were observed for ALS among workers of metal mines (RR 2.21, 95% CI 1.04 to 4.69) and for motor neuron disease among those employed in mining occupations within metal mining industries (RR 1.96, 95% CI 1.01 to 3.79), though these were based on relatively few cases. In miscellaneous metal mines, workers who held mining occupations had an elevated rate of Alzheimer’s disease (RR 1.27, 95% CI 0.92 to 1.77). Parkinson’s disease rate was elevated among workers with rock and soil drilling occupations (RR 1.60, 95% CI 1.04 to 2.45).ConclusionsMining hazards may be associated with elevated rates of neurodegenerative diseases among workers in mining occupations and industries. More work is needed to better understand mining exposures and their associations with neurodegenerative diseases.


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