scholarly journals Contributing to the early detection of Rett syndrome: The potential role of auditory Gestalt perception

2012 ◽  
Vol 33 (2) ◽  
pp. 461-466 ◽  
Author(s):  
Peter B. Marschik ◽  
Christa Einspieler ◽  
Jeff Sigafoos
Keyword(s):  
Early Detection ◽  
Rett Syndrome ◽  
Potential Role ◽  
Gestalt Perception

Potential Role of Cytokines in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis

2011 ◽  
Vol 11 (1) ◽  
pp. 130-133
Author(s):  
Astra Zviedre ◽  
Arnis Engelis ◽  
Mohit Kakar ◽  
Aigars Pētersons
Keyword(s):  
Early Detection ◽  
Acute Appendicitis ◽  
Inflammatory Mediators ◽  
Potential Role ◽  
Clinical Symptoms ◽  
Future Research ◽  
Mesenteric Lymphadenitis ◽  
Proper Diagnosis ◽  
Near Future

Potential Role of Cytokines in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis Although, AAP and AML have different etiological factors, clinical symptoms are very much similar but treatment tactics in both the disease differ a lot. In case of AML, treatment is more conservative and does not require hospitalization while in case of AAP immediate hospitalization and maybe further surgery can be mandatory. With the identification of group of cytokines serum inflammatory mediators IL-8, IL-10, IL-12[p70], IL-17, TNF-a and MCP-1, it is believed early and proper diagnosis of AAP in the near future. Research of cytokines-serum inflammatory mediators has opened new opportunities for an early detection and differentiation of these two diseases in children.

Adenocarcinoma in the ileal pouch: early detection and potential role of fecal DNA methylated markers in surveillance

2010 ◽  
Vol 26 (7) ◽  
pp. 951-953 ◽  
Author(s):  
Emmanuel C. Obusez ◽  
Yiding Liu ◽  
Ana E. Bennett ◽  
Feza H. Remzi ◽  
Baochuan Guo ◽  
...  
Keyword(s):  
Early Detection ◽  
Potential Role ◽  
Ileal Pouch ◽  
Fecal Dna

scholarly journals POTENTIAL ROLE OF SERUM PERIOSTIN IN THE EARLY DETECTION OF BRONCHIAL ASTHMA IN CHILDREN

2016 ◽  
Vol 15 (5) ◽  
pp. 452-456 ◽  
Author(s):  
N. V. Sobotyuk ◽  
V. P. Gaponenko ◽  
S. V. Bochantsev ◽  
S. A. Golochalova ◽  
I. V. Sazonova ◽  
...  
Keyword(s):  
Early Detection ◽  
Bronchial Asthma ◽  
Potential Role ◽  
Asthma In Children ◽  
Serum Periostin

scholarly journals Lovastatin fails to improve motor performance and survival in methyl-CpG-binding protein2-null mice

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Claudia Villani ◽  
Giuseppina Sacchetti ◽  
Renzo Bagnati ◽  
Alice Passoni ◽  
Federica Fusco ◽  
...  
Keyword(s):  
Rett Syndrome ◽  
Potential Role ◽  
Cholesterol Metabolism ◽  
Cholesterol Homeostasis ◽  
Motor Deficits ◽  
Brain Cholesterol ◽  
Background Strain ◽  
Cholesterol Levels ◽  
The Brain

Previous studies provided evidence for the alteration of brain cholesterol homeostasis in 129.Mecp2-null mice, an experimental model of Rett syndrome. The efficacy of statins in improving motor symptoms and prolonging survival of mutant mice suggested a potential role of statins in the therapy of Rett syndrome. In the present study, we show that Mecp2 deletion had no effect on brain and reduced serum cholesterol levels and lovastatin (1.5 mg/kg, twice weekly as in the previous study) had no effects on motor deficits and survival when Mecp2 deletion was expressed on a background strain (C57BL/6J; B6) differing from that used in the earlier study. These findings indicate that the effects of statins may be background specific and raise important issues to consider when contemplating clinical trials. The reduction of the brain cholesterol metabolite 24S-hydroxycholesterol (24S-OHC) found in B6.Mecp2-null mice suggests the occurrence of changes in brain cholesterol metabolism and the potential utility of using plasma levels of 24S-OHC as a biomarker of brain cholesterol homeostasis in RTT.

Chronic allograft nephropathy – a clinical syndrome: early detection and the potential role of proliferation signal inhibitors

2009 ◽  
Vol 23 (6) ◽  
pp. 769-777 ◽  
Author(s):  
Josep M. Campistol ◽  
Ioannis N. Boletis ◽  
Jacques Dantal ◽  
Johan W. de Fijter ◽  
Alexandre Hertig ◽  
...  
Keyword(s):  
Early Detection ◽  
Potential Role ◽  
Clinical Syndrome ◽  
Chronic Allograft Nephropathy ◽  
Proliferation Signal Inhibitors
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