Antipsychotics and Attenuated Psychosis Syndrome: Transdiagnostic assessment and discontinuation strategies

Author(s):  
Paolo Fusar-Poli ◽  
Gonzalo Salazar de Pablo
Psychiatriki ◽  
2017 ◽  
Vol 28 (2) ◽  
pp. 120-130
Author(s):  
G. Samiotakis ◽  
C. Kollias ◽  
H. Lazaratou ◽  
D. Anagnostopoulos ◽  
V. Kontaxakis

Author(s):  
Julio Vaquerizo-Serrano ◽  
Gonzalo Salazar de Pablo ◽  
Jatinder Singh ◽  
Paramala Santosh

AbstractPsychotic experiences can occur in autism spectrum disorders (ASD). Some of the ASD individuals with these experiences may fulfil Clinical High-Risk for Psychosis (CHR-P) criteria. A systematic literature search was performed to review the information on ASD and CHR-P. A meta-analysis of the proportion of CHR-P in ASD was conducted. The systematic review included 13 studies. The mean age of ASD individuals across the included studies was 11.09 years. The Attenuated Psychosis Syndrome subgroup was the most frequently reported. Four studies were meta-analysed, showing that 11.6% of CHR-P individuals have an ASD diagnosis. Symptoms of prodromal psychosis may be present in individuals with ASD. The transition from CHR-P to psychosis is not affected by ASD.


2018 ◽  
Vol 24 (3) ◽  
pp. 169-178 ◽  
Author(s):  
ZACHARY D. ZUSCHLAG ◽  
JEFFREY E. KORTE ◽  
MARK HAMNER

2020 ◽  
Vol 77 (3) ◽  
pp. 311 ◽  
Author(s):  
Gonzalo Salazar de Pablo ◽  
Ana Catalan ◽  
Paolo Fusar-Poli

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Woo-Sung Kim ◽  
Guangfan Shen ◽  
Congcong Liu ◽  
Nam-In Kang ◽  
Keon-Hak Lee ◽  
...  

Abstract Altered resting-state functional connectivity (FC) of the amygdala (AMY) has been demonstrated to be implicated in schizophrenia (SZ) and attenuated psychosis syndrome (APS). Specifically, no prior work has investigated FC in individuals with APS using subregions of the AMY as seed regions of interest. The present study examined AMY subregion-based FC in individuals with APS and first-episode schizophrenia (FES) and healthy controls (HCs). The resting state FC maps of the three AMY subregions were computed and compared across the three groups. Correlation analysis was also performed to examine the relationship between the Z-values of regions showing significant group differences and symptom rating scores. Individuals with APS showed hyperconnectivity between the right centromedial AMY (CMA) and left frontal pole cortex (FPC) and between the laterobasal AMY and brain stem and right inferior lateral occipital cortex compared to HCs. Patients with FES showed hyperconnectivity between the right superficial AMY and left occipital pole cortex and between the left CMA and left thalamus compared to the APS and HCs respectively. A negative relationship was observed between the connectivity strength of the CMA with the FPC and negative-others score of the Brief Core Schema Scales in the APS group. We observed different altered FC with subregions of the AMY in individuals with APS and FES compared to HCs. These results shed light on the pathogenetic mechanisms underpinning the development of APS and SZ.


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