Management of systemic risk factors for chronic tendinopathy

AimsTo report the 6-year incidence of optical coherence tomography (OCT)-derived age-related changes in drusen volume and related systemic and ocular associations.MethodsChinese adults aged 40 years and older were assessed at baseline and 6 years with colour fundus photography (CFP) and spectral domain (SD) OCT. CFPs were graded for age-related macular degeneration (AMD) features and drusen volume was generated using commercially available automated software.ResultsA total of 4172 eyes of 2580 participants (mean age 58.12±9.03 years; 51.12% women) had baseline and 6-year follow-up CFP for grading, of these, 2130 eyes of 1305 participants had gradable SD-OCT images, available for analysis. Based on CFP grading, 136 (3.39%) participants developed incident early AMD and 10 (0.25%) late AMD. Concurrently, retinal pigment epithelial-Bruch’s membrane (RPE-BrC) volumes decreased, remained stable and increased in 6.8%, 78.5% and 14.7%, respectively, over 6 years. In eyes where RPE-BrC volumes were >0 mm3 at baseline, this was associated with two-fold higher prevalence rate of any AMD at baseline (p<0.001). Multivariable analysis showed that when compared with eyes where RPE-BrC volume was unchanged, volume decrease was significantly associated with older age (OR=1.30; p<0.001), smoking (OR=2.21; p=0.001) and chronic kidney disease (OR=3.4, p=0.008), while increase was associated with older age (OR=1.36; p<0.001) and hypertension (OR=1.43; p=0.016).ConclusionAMD incidence detected at 6 years on CFP and correlated OCT-derived drusen volume measurement change is low. Older age and some systemic risk factors are associated with drusen volume change, and our data provide new insights into relationship between systemic risk factors and outer retinal morphology in Asian eyes.

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Systemic and Genetic Risk Factors in Diabetic Retinopathy and Diabetic Macular Edema

Güncel Retina Dergisi (Current Retina Journal) ◽

10.37783/crj-0077 ◽

2018 ◽

pp. 102-107

Keyword(s):

Risk Factors ◽

Diabetic Retinopathy ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Systemic Risk ◽

Genetic Effect ◽

Current Treatment ◽

Genetic Studies ◽

Patient Subgroups ◽

Systemic Risk Factors

Diabetic retinopathy (DR) is an increasingly common health problem in our country as it is all over the world. DR is a leading cause of loss of vision patients at a productive age. Current treatment of diabetic macular edema (DME) is distressing, expensive, and not suitable for some patient subgroups. For this reason, the development and progression of DR and DME are affected by many systemic risk factors. It is important to increase the understanding of these responsible risk factors and develop preventive strategies. However, the presence of systemic risk factors is inadequate to predict the progression of the disease on an individual basis. It indicates the presence of a genetic effect. In this review, we have summarized the known systemic risk factors as well as the genetic basis of the disease under the light of genetic studies.

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Systemic Risk Factors for the Development of Periimplant Diseases

Implant Dentistry ◽

10.1097/id.0000000000000873 ◽

2019 ◽

Vol 28 (2) ◽

pp. 115-119 ◽

Cited By ~ 9

Author(s):

Purnima S. Kumar

Keyword(s):

Risk Factors ◽

Systemic Risk ◽

Systemic Risk Factors

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Retrospective cohort study of a tapered implant with high primary stability in patients with local and systemic risk factors—7-year data

International Journal of Implant Dentistry ◽

10.1186/s40729-018-0151-5 ◽

2018 ◽

Vol 4 (1) ◽

Cited By ~ 1

Author(s):

Sotirios Konstantinos Saridakis ◽

Wilfried Wagner ◽

Robert Noelken

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Systemic Risk ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Primary Stability ◽

Systemic Risk Factors

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Atherosclerosis at arterial bifurcations: evidence for the role of haemodynamics and geometry

Thrombosis and Haemostasis ◽

10.1160/th15-07-0597 ◽

2016 ◽

Vol 115 (03) ◽

pp. 484-492 ◽

Cited By ~ 75

Author(s):

Umberto Morbiducci ◽

Annette M. Kok ◽

Brenda R. Kwak ◽

Peter H. Stone ◽

David A. Steinman ◽

...

Keyword(s):

Risk Factors ◽

Shear Stress ◽

Systemic Risk ◽

Biological Response ◽

Arterial System ◽

Ample Evidence ◽

Fluid Forces ◽

Flow Features ◽

Systemic Risk Factors

SummaryAtherosclerotic plaques are found at distinct locations in the arterial system, despite the exposure to systemic risk factors of the entire vascular tree. From the study of arterial bifurcation regions, emerges ample evidence that haemodynamics are involved in the local onset and progression of the atherosclerotic disease. This observed co-localisation of disturbed flow regions and lesion prevalence at geometrically predisposed districts such as arterial bifurcations has led to the formulation of a ‘haemodynamic hypothesis’, that in this review is grounded to the most current research concerning localising factors of vascular disease. In particular, this review focuses on carotid and coronary bifurcations because of their primary relevance to stroke and heart attack. We highlight reported relationships between atherosclerotic plaque location, progression and composition, and fluid forces at vessel’s wall, in particular shear stress and its ‘easier-tomeasure’ surrogates, i.e. vascular geometric attributes (because geometry shapes the flow) and intravascular flow features (because they mediate disturbed shear stress), in order to give more insight in plaque initiation and destabilisation. Analogous to Virchow’s triad for thrombosis, atherosclerosis must be thought of as subject to a triad of, and especially interactions among, haemodynamic forces, systemic risk factors, and the biological response of the wall.

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