scholarly journals Acute phase serum amyloid A induces proinflammatory cytokines and mineralization via toll-like receptor 4 in mesenchymal stem cells

2015 ◽  
Vol 15 (1) ◽  
pp. 231-239 ◽  
Author(s):  
Regina Ebert ◽  
Peggy Benisch ◽  
Melanie Krug ◽  
Sabine Zeck ◽  
Jutta Meißner-Weigl ◽  
...  
2013 ◽  
Vol 6 (1) ◽  
Author(s):  
Michelle B Christensen ◽  
Jens Christian Sørensen ◽  
Stine Jacobsen ◽  
Mads Kjelgaard-Hansen

2011 ◽  
Vol 216 (2) ◽  
pp. 266-268
Author(s):  
Sidika Karakas ◽  
Rami Mortada ◽  
Clinical Fellow

1979 ◽  
Vol 150 (3) ◽  
pp. 597-606 ◽  
Author(s):  
J D Sipe ◽  
S N Vogel ◽  
J L Ryan ◽  
K P McAdam ◽  
D L Rosenstreich

The mechanism by which LPS stimulates an acute phase serum amyloid A (SAA) response in C3H mice has been studied. A factor (SAA inducer) appears in the blood of C3H/HeN (lipopolysaccharide [LPS]-sensitive) mice approximately 1 h after administration of LPS, which, when passively administered, can induce C3H/HeJ mice to produce SAA although they are resistant to the LPS itself. SAA inducer has been detected in the culture medium of LPS treated C3H/HeN macrophages but not spleen cells. Thus, two stages in the induction of the acute phase SAA response are now recognized: a latent period of 2-3 h during which the SAA concentration remains at baseline values and in which SAA inducer appears, and the period of synthesis of SAA which lasts for approoximately 24 h past induction. It is proposed that a macrophage response to LPS is responsible for production of the serum mediator which induces SAA synthesis.


1982 ◽  
Vol 389 (1 C-Reactive Pr) ◽  
pp. 137-150 ◽  
Author(s):  
Jean D. Sipe ◽  
Stefanie N. Vogel ◽  
Marcela B. Sztein ◽  
Martha Skinner ◽  
Alan S. Cohen

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