Cardiac involvement in antiphospholipid syndrome: The diagnostic role of noninvasive cardiac imaging

2016 ◽  
Vol 45 (5) ◽  
pp. 611-616 ◽  
Author(s):  
Sophie I. Mavrogeni ◽  
Petros P. Sfikakis ◽  
George D. Kitas ◽  
Genovefa Kolovou ◽  
Maria G. Tektonidou
Keyword(s):  
Antiphospholipid Syndrome ◽  
Cardiac Imaging ◽  
Cardiac Involvement ◽  
Noninvasive Cardiac Imaging ◽  
Diagnostic Role

scholarly journals Improvement of Cardiac Vegetations in Antiphospholipid Syndrome with Enoxaparin and Corticosteroids after Rivaroxaban Failure

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Eric Granowicz ◽  
Kiyon Chung
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Autoimmune Disease ◽  
Acute Heart Failure ◽  
Antiphospholipid Syndrome ◽  
Steroid Therapy ◽  
Cardiac Disease ◽  
Marked Improvement ◽  
Cardiac Involvement

Cardiac disease is a well-known complication of antiphospholipid syndrome (APS), with many patients presenting with valvular thickening or vegetations, referred to as Libman–Sacks endocarditis (LSE). Because cases of APS with cardiac involvement are relatively rare, paucity of large clinical trials studying this complication has made management challenging. In the absence of acute heart failure and embolic events, a medical approach is usually selected, consisting of anticoagulation and possibly corticosteroids when another underlying autoimmune disease is present. However, the role of various anticoagulant classes and the duration of steroid therapy continue to be debated. Here, we present a 45-year-old woman who developed two vegetations in the setting of secondary APS while taking rivaroxaban before experiencing marked improvement with the use of enoxaparin and steroids.

scholarly journals Role of endothelial cell specific molecule-1 (endocan) and cardiac imaging in early detection of cardiac involvement in psoriatic patients with or without arthritis

2022 ◽  
Vol 44 (2) ◽  
pp. 159-164
Author(s):  
Salwa M.A. Ibrahim ◽  
Hala M.A. Sabah ◽  
Ahmed I. Eldesoky ◽  
Marwa Y. Soltan ◽  
Hebatallah A. Elshamy ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Early Detection ◽  
Cardiac Imaging ◽  
Cardiac Involvement

scholarly journals The Role of Cardiac Imaging in the Evaluation of Cardiac Involvement in Systemic Diseases

Cureus ◽  
2021 ◽  
Author(s):  
Kelash Kumar ◽  
Karthik Seetharam ◽  
Fnu Poonam ◽  
Amit Gulati ◽  
Adnan Sadiq ◽  
...  
Keyword(s):  
Cardiac Imaging ◽  
Cardiac Involvement ◽  
Systemic Diseases

Cardiac Manifestations of Antiphospholipid Syndrome: Clinical Presentation, Role of Cardiac Imaging, and Treatment Strategies

2019 ◽  
Vol 45 (05) ◽  
pp. 468-477 ◽  
Author(s):  
Antonella Tufano ◽  
Matteo Nicola Dario Di Minno ◽  
Anna Guida ◽  
Maria Lembo ◽  
Giovanni Di Minno ◽  
...  
Keyword(s):  
Heart Disease ◽  
Antiphospholipid Syndrome ◽  
Cardiac Imaging ◽  
High Titer ◽  
Left Ventricular ◽  
Immunoglobulin M ◽  
Pregnancy Morbidity ◽  
Heart Involvement ◽  
Cardiac Manifestations

AbstractAntiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of antiphospholipid antibodies, vascular thrombosis (venous, arterial, or small vessels), and/or pregnancy morbidity. Diagnosis of APS is based on the presence of at least one clinical criterion (thrombotic events or pregnancy morbidity) and at least one of the laboratory criteria (persistently medium/high titer immunoglobulin G [IgG]/immunoglobulin M [IgM] anticardiolipin antibodies, and/or medium/high titer IgG/IgM anti-β2-glycoprotein I antibodies, and/or a positive lupus anticoagulant test), confirmed after repetition at least 12 weeks apart. The clinical spectrum of APS encompasses additional (extracriteria) clinical manifestations, including cardiac diseases. Heart involvement may become evident as a consequence of direct (autoimmune-mediated) or indirect (thrombosis) mechanisms, and include valve heart disease (vegetations and/or thickening associated with functional abnormalities) and intracardiac thrombosis, coronary, and vascular accelerated atherosclerosis, along with ischemic heart disease. APS can also cause pulmonary arterial hypertension, left ventricular dysfunction, and heart failure. This review describes the major cardiac manifestations of APS and illustrates the role of cardiac imaging for diagnosing subclinical and overt heart involvement and addressing management of these patients. The possible role of therapeutic strategies in cardiac manifestations of APS is also discussed.

scholarly journals Role of cardiac imaging in Anderson-Fabry cardiomyopathy

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Walter Serra ◽  
Nicola Marziliano
Keyword(s):  
Cardiac Imaging

scholarly journals 332 The diagnostic role of shunt series radiographs (SSR) in children presenting to the children’s emergency department (CED) with suspected ventriculoperitoneal (VP) shunt failure

2020 ◽  
Vol 37 (12) ◽  
pp. 852.3-853
Author(s):  
Angharad Griffiths ◽  
Ikechukwu Okafor ◽  
Thomas Beattie
Keyword(s):  
Clinical Outcome ◽  
Sensitivity And Specificity ◽  
Clinical Information ◽  
Flow Diagram ◽  
List Type ◽  
Shunt Failure ◽  
Vp Shunt ◽  
Wide Range ◽  
Diagnostic Role

Aims/Objectives/BackgroundVP shunts are used to drain CSF from the cranial vault because of a wide range of pathologies and, like any piece of hardware, can fail. Traditionally investigations include SSR and CT. This project examines the role of SSR in evaluating children with suspected VP shunt failure.Primary outcome: Sensitivity and specificity of SSR in children presenting to the CED with concern for shunt failure.Methods/DesignConducted in a single centre, tertiary CED of the national Irish Neurosurgical(NS) referral centre (ED attendance:>50,000 patients/year). 100 sequential SSR requested by the CED were reviewed. Clinical information was extracted from electronic requests. Shunt failure was defined by the need for NS intervention(Revision).Abstract 332 Figure 1Abstract 332 Figure 2Results/ConclusionsSensitivity and specificity is presented in figure 1 (two by two table).100 radiographs performed in 84 children.22% shunts revised (see flow diagram).7 SSR’s were abnormal.85% (n=6) shunts revised. [5 following abnormal CT].Of the normal SSR’s; 16 had abnormal CT and revised.85/100 received CT.64 of 85 CT’s (75%) were normal.□6 of the 64 had focal shunt concern.SSR’s shouldn’t be used in isolation. NPV&PPV, Sensitivity&Specificity is low.SSR’s are beneficial where there’s concern over focal shunt problems (injury/pain/swelling) or following abnormal CT.VP shunt failure is not well investigated with SSR alone.SSR’s could be omitted where there is no focal shunt concern/after normal CT (without impacting clinical outcome) reducing radiation exposure and reduce impact on CED’s.59 SSR’s could have been avoided without adverse clinical outcome.

Double-Balloon Enteroscopy in Detecting Small-Bowel Neuroendocrine Neoplasms: A Single-Center Prospective Study

Digestion ◽  
2020 ◽  
pp. 1-9
Author(s):  
Roberta Elisa Rossi ◽  
Luca Elli ◽  
Federica Branchi ◽  
Dario Conte ◽  
Sara Massironi
Keyword(s):  
Small Bowel ◽  
Neuroendocrine Neoplasm ◽  
Unknown Primary ◽  
Neuroendocrine Neoplasms ◽  
Double Balloon Enteroscopy ◽  
Balloon Enteroscopy ◽  
Double Balloon ◽  
Diagnostic Role ◽  
Positive Results

<b><i>Background and Aim:</i></b> Small-bowel neuroendocrine neoplasm (sbNEN) diagnosis has improved with double-balloon enteroscopy (DBE). DBE efficacy in the detection of sbNENs is unknown. We aimed to report the experience at a single referral center for NENs. <b><i>Methods:</i></b> All consecutive patients with a suspected sbNEN selected for diagnostic DBE were enrolled. <b><i>Results:</i></b> Between 2011 and 2016, 25 patients were referred for a suspected sbNEN. In 15/25 patients, a primary NEN was detected outside the small bowel; in 4, NEN was excluded. After extensive workup, 6 patients (4 males, median age 50 years) underwent DBE (3 anterograde, 2 retrograde, and 1 both; median time: 60 min; median insertion 200 cm). DBE was positive in 3 patients: one had an ileal 2-cm NEN G1, one had an ileal 1.3-cm NEN G1, and one had an ileal 1-cm NEN G2, all surgically removed. Of the 3 other patients, one had a metastatic NEN of unknown primary, the other two had small intestinal NENs, both surgically removed (1.6-cm G1 and G2 NEN). DBE showed a sensitivity of 60% and, in absence of false-positive results, a specificity of 100%. Accuracy resulted 67%. No complications were observed. <b><i>Conclusions:</i></b> In line with data from the literature, the present series showed that DBE is a safe and effective procedure in the diagnosis of sbNENs. Further studies are needed to better clarify the diagnostic role of DBE in the neuroendocrine tumor setting and its relationship with other techniques.

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