A Meta-Analysis of Clinical Manifestations in Asian Systemic Lupus Erythematous: The Effects of Ancestry, Ethnicity and Gender

2021 ◽  
Author(s):  
Ming Hui Lee ◽  
Jeffery Wei Heng Koh ◽  
Cheng Han Ng ◽  
Sandy H.H. Lim ◽  
Jiacai Cho ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Clinical Manifestations ◽  
Systemic Lupus Erythematous ◽  
Systemic Lupus ◽  
And Gender ◽  
Ethnicity And Gender

scholarly journals Impacts of FcγRIIB and FcγRIIIA gene polymorphisms on systemic lupus erythematous disease activity index

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Mansoor Karimifar ◽  
Khosro Akbari ◽  
Reza ArefNezhad ◽  
Farshid Fathi ◽  
Mohammad Moosaeepour ◽  
...  
Keyword(s):  
Disease Activity ◽  
Activity Index ◽  
Clinical Manifestations ◽  
Disease Activity Index ◽  
Unknown Etiology ◽  
Systemic Lupus Erythematous ◽  
Nucleotide Polymorphisms ◽  
Systemic Lupus ◽  
Single Nucleotide ◽  
Chronic Autoimmune Disease

Abstract Objective Systemic lupus erythematous (SLE) disease is a chronic autoimmune disease with unknown etiology that can involve different organs. Polymorphisms in Fcγ receptors have been identified as genetic factors in susceptibility to SLE. This study was aimed to investigate effects of two single nucleotide polymorphisms (SNPs) within FcγRIIB and FcγRIIIA genes on systemic lupus erythematous disease activity index (SLEDAI) in an Iranian population. Results Our findings indicated TT and GG genotypes were the common genotypes of FcγRIIB and FcγRIIIA SNPs in SLE patients, respectively. There were no significant differences in genotype and allele frequencies of FcγRIIB and FcγRIIIA SNPs in SLE and healthy subjects. However, the frequencies of genotypes and alleles of FcγRIIB and FcγRIIIA SNPs were significantly associated with some clinical manifestations used to determine SLEDAI (P < 0.001–0.5).

scholarly journals Association between ABCG2 Q141K polymorphism and gout risk affected by ethnicity and gender: a systematic review and meta-analysis

2014 ◽  
Vol 18 (4) ◽  
pp. 382-391 ◽  
Author(s):  
Zheng Dong ◽  
Shicheng Guo ◽  
Yajun Yang ◽  
Junjie Wu ◽  
Ming Guan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
And Gender ◽  
Ethnicity And Gender

scholarly journals Case Report: Case report: Systemic lupus erythematous associated with thrombotic thrombocytopenic purpura, a diagnostic challenge

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 552
Author(s):  
Horacio Suárez-Ale ◽  
Elizabeth Fabian-Aquino ◽  
Virgilio E Failoc-Rojas ◽  
Vicente A Benites-Zapata ◽  
Felipe Ignacio-Cconchoy
Keyword(s):  
Case Report ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Clinical Manifestations ◽  
Health Condition ◽  
Therapeutic Interventions ◽  
Severe Thrombocytopenia ◽  
Systemic Lupus Erythematous ◽  
Systemic Lupus ◽  
Diagnostic Challenge ◽  
Thrombocytopenic Purpura

Thrombotic thrombocytopenic purpura (TTP) is an uncommon microangiopathic disease and often occurs as a complication of systemic lupus erythematous (SLE). However, this probable causal relationship has not been completely proven. The diagnostic differentiation of both diseases is difficult in the first instance because they share similar characteristics that may overlap. We present a case of a 32-year-old woman with antecedents of epilepsy since she was 12 years old. The patient was admitted to the emergency room with a clinical picture of headaches, fever, paleness in the skin and mucosa, confused state, paresthesia, and transient spasticity of the extremities. The laboratory results revealed Coombs negative direct autoimmune hemolytic anaemia, severe thrombocytopenia, significant elevation of the enzyme lactate dehydrogenase, and presence of schistocytes ++ in the peripheral film.  In addition, positive antinuclear antibodies and positive anti-native DNA in titers of 1/320 and 1/160, respectively, were found. Renal function was conserved. We concluded that it was a case of TTP associated with SLE and indicated treatment with plasmapheresis and methylprednisolone pulses, obtaining a satisfactory response (normalization of biomarker levels, health condition) after the second session of plasmapheresis. Diagnosis of both SLE and TTP is often difficult to achieve; however, adequate correlation of clinical manifestations and laboratory tests, along with the help of partial therapeutic interventions, may lead to good clinical response.

scholarly journals Impacts of FcγRIIB and FcγRIIIA Gene Polymorphisms on Systemic Lupus Erythematous Disease Activity Index

2021 ◽  
Author(s):  
Mansoor Karimifar ◽  
Khosro Akbari ◽  
Farshid Fathi ◽  
Reza ArefNejad ◽  
Mohammad Moosaeepour ◽  
...  
Keyword(s):  
Disease Activity ◽  
Activity Index ◽  
Clinical Manifestations ◽  
Disease Activity Index ◽  
Unknown Etiology ◽  
Systemic Lupus Erythematous ◽  
Nucleotide Polymorphisms ◽  
Systemic Lupus ◽  
Single Nucleotide ◽  
Chronic Autoimmune Disease

Abstract Objective: Systemic lupus erythematous (SLE) disease is a chronic autoimmune disease with unknown etiology that can involve different organs. Polymorphisms in Fcγ receptors have been identified as genetic factors in susceptibility to SLE. This study was aimed to investigate effects of two single nucleotide polymorphisms (SNPs) within FcγRIIB and FcγRIIIA genes on systemic lupus erythematous disease activity index (SLEDAI) in an Iranian population. Results: Our findings indicated TT and GG genotypes were the common genotypes of FcγRIIB and FcγRIIIA SNPs in SLE patients, respectively. There were no significant differences in genotype and allele frequencies of FcγRIIB and FcγRIIIA SNPs in SLE and healthy subjects. However, the frequencies of genotypes and alleles of FcγRIIB and FcγRIIIA SNPs were significantly associated with some clinical manifestations used to determine SLEDAI (P<0.001-0.5).

scholarly journals Marital status and age of systemic lupus erythematous diagnosis: the potential for differences related to sex and gender

2019 ◽  
Vol 6 (1) ◽  
pp. e000325
Author(s):  
Eugene Brailovski ◽  
Evelyne Vinet ◽  
Christian A Pineau ◽  
Jennifer Lee ◽  
Luck Lukusa ◽  
...  
Keyword(s):  
General Population ◽  
Marital Status ◽  
Family Relationships ◽  
Common Law ◽  
Systemic Lupus Erythematous ◽  
Sex And Gender ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
And Gender ◽  
Sectional Analysis

ObjectivesChronic rheumatic diseases can challenge social and family relationships. We compared marital status in patients with systemic lupus erythematous (SLE) with their general population counterparts, stratified by sex and age of SLE onset.MethodsWe performed a cross-sectional analysis of a cohort of 382 patients with SLE at our centre (349 females, 33 males). We determined how many were married or living common-law at the time of last study visit. Patients were then divided into: SLE diagnosis before 18, between 18 and 30, between 31 and 44 and after 45 years of age. We then compared marital status among male and female patients with SLE, to Quebec age-specific marital statistics.ResultsOf 382 patients with SLE, 202 (52.9%) were married or living common-law, which was 9% lower than general population rates (95% CI 2% to 16%). One-third of women with paediatric-onset SLE were married or living common-law, which was 28% lower than their general population counterparts (95% CI 6% to 46%). Half of women diagnosed between age 18 and 30 were married or living common law, which was 14% less than general population rates (95% CI 4% to 25%). We could not establish significant differences for women diagnosed after age 30, or for males, versus their general population counterparts.ConclusionsWomen diagnosed with SLE before age 30 were less likely to be married/living common-law, versus general population rates. This was not apparent for those diagnosed later in life. We did not clearly establish this effect in males, possibly due to power issues (vs a true effect of sex/gender). Additional studies (eg, focus groups) could elucidate reasons for our findings.

Description of Malignancy Rates in Childhood- and Adult-Onset Systemic Lupus Erythematous by Proportional Meta-analysis

2017 ◽  
Vol 23 (4) ◽  
pp. 187-192 ◽  
Author(s):  
Priscila Rodrigues da Silva Aoki ◽  
Regina El Dib ◽  
Clovis Artur Almeida Silva ◽  
Claudia Saad Magalhaes
Keyword(s):  
Meta Analysis ◽  
Systemic Lupus Erythematous ◽  
Adult Onset ◽  
Systemic Lupus
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