scholarly journals Epidemiological characterization of serotype group B Streptococci neonatal infections associated with interleukin-6 level as a sensitive parameter for the early diagnosis

2018 ◽  
Vol 25 (7) ◽  
pp. 1356-1364
Author(s):  
Amal A. Al Hazzani ◽  
Reham A.B. Bawazeer ◽  
Afaf I. Shehata
Keyword(s):  
Early Diagnosis ◽  
Interleukin 6 ◽  
Neonatal Infections ◽  
Group B Streptococci ◽  
Sensitive Parameter ◽  
Group B ◽  
Epidemiological Characterization

Immunochemical Characterization of the Polysaccharide Antigens of Group B Streptococci

1988 ◽  
Vol 10 (Supplement 2) ◽  
pp. S367-S371 ◽  
Author(s):  
D. G. Pritchard ◽  
M. L. Egan ◽  
B. M. Gray ◽  
H. C. Dillon
Keyword(s):  
Group B Streptococci ◽  
Immunochemical Characterization ◽  
Polysaccharide Antigens ◽  
Group B

scholarly journals Changes in incidence and etiology of early-onset neonatal infections 1997–2017 – a retrospective cohort study in western Sweden

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Margrét Johansson Gudjónsdóttir ◽  
Anders Elfvin ◽  
Elisabet Hentz ◽  
Ingegerd Adlerberth ◽  
Ingemar Tessin ◽  
...  
Keyword(s):  
Early Onset ◽  
Antimicrobial Prophylaxis ◽  
List Type ◽  
Neonatal Infections ◽  
Group B Streptococci ◽  
Gram Negative ◽  
Live Births ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Group B

Abstract Background The objective of the study was to evaluate data on early-onset neonatal invasive infections in western Sweden for the period 1997–2017. To identify changes in incidence, etiology and mortality and compare to previous studies from the same area starting from 1975. Methods Observational epidemiological, retrospective study on infants 0–6 days of age with a positive culture in blood and/or cerebrospinal fluid between 1997 and 2017. A comparison was made of the incidence between 2008 and 2017 compared to 1997–2007. Changes in the incidence of infections due to Group B streptococci, Staphylococcus aureus and aerobic Gram-negative rods were assessed from 1975. Results The total incidence, including both recognized pathogens and commensals as causative agents, was 1.1/1000 live births. The incidence declined from 1.4/1000 LB in 1997–2007 to 0.9/1000 LB in 2008–2017 but the case-fatality rate remained unchanged, (8/119 vs 7/90), at 7%. Among the 209 patients identified during 1997–2017 with sepsis or meningitis the most common organisms were Group B streptococci (40%, 84/209), S. aureus (16%, 33/209) and E. coli (9%, 18/209). The incidence of Group B streptococci infections went from 0.9/1000 live births 1987–1996 to 0.45/1000 live births 1997–2017 and all cases were within 72 h. The proportion of extremely preterm infants (< 28 weeks gestation) rose steadily during the study period but there was no rise in infections due to Gram-negative organisms. The spectrum of cultured organisms changed after 72 h as commensal organisms started to emerge. Conclusion There has been a decrease in the incidence of neonatal early-onset infections compared to previous studies in western Sweden. The incidence of GBS infections was not as low as in other reports. Further studies are needed to assess if screening-based intra partum antimicrobial prophylaxis instead of a risk factor-based approach for identifying candidates for intrapartum antimicrobial prophylaxis would be a better option for this study area. Key notes This study is one of the longest running follow-ups in the world, a follow-up of 43 years of early-onset neonatal infections.The incidence of early-onset GBS infections is higher in Western Sweden compared to other local reports.No difference in the incidence of early-onset GBS depending on the definition of early-onset being within 72 h or 7 days of life.

Characterization of an IgA receptor from group B streptococci: specificity for serum IgA

1990 ◽  
Vol 20 (10) ◽  
pp. 2241-2247 ◽  
Author(s):  
Gunnar Lindahl ◽  
Bo Åkerström ◽  
Jean-Pierre Vaerman ◽  
Lars Stenberg
Keyword(s):  
Group B Streptococci ◽  
Serum Iga ◽  
Group B

scholarly journals Group B Streptococci Causing Neonatal Infections in Barcelona Are a Stable Clonal Population: 18-Year Surveillance

2011 ◽  
Vol 49 (8) ◽  
pp. 2911-2918 ◽  
Author(s):  
E. R. Martins ◽  
A. Andreu ◽  
P. Correia ◽  
T. Juncosa ◽  
J. Bosch ◽  
...  
Keyword(s):  
Neonatal Infections ◽  
Group B Streptococci ◽  
Clonal Population ◽  
Group B

Characterization of group B streptococcal glyceraldehyde-3-phosphate dehydrogenase: surface localization, enzymatic activity, and protein–protein interactions

2003 ◽  
Vol 49 (5) ◽  
pp. 350-356 ◽  
Author(s):  
Kyle N Seifert ◽  
William P McArthur ◽  
Arnold S Bleiweis ◽  
L Jeannine Brady
Keyword(s):  
Monoclonal Antibody ◽  
Western Blot ◽  
Protein Interactions ◽  
Fluid Phase ◽  
Protein Protein Interactions ◽  
Group B Streptococci ◽  
Whole Cells ◽  
Surface Localization ◽  
Group B

During characterization of the surface antigens of serotype III group B streptococci (GBS), a protein with an apparent Mr~ 173 500 migrating on a SDS – polyacrylamide gel was found to have an N-terminal amino acid sequence identical to that of the plasmin receptor (Plr) of group A streptococci, a surface-localized glyceraldehyde-3-phosphate dehydrogenase (GAPDH). This work begins to characterize GBS GAPDH and to assess its functional activity on the cell surface. The 1.0-kb gapC gene of GBS was amplified by PCR. plr and gapC demonstrated 87% homology. An anti-Plr monoclonal antibody reacted with GBS whole cells, suggesting GBS GAPDH is surface localized. Multiple serotypes of GBS demonstrated functional GAPDH on their surfaces. The anti-Plr monoclonal antibody recognized GBS protein bands of approximately 41 and 173.5 kDa, by Western blot. Presumably, these represent monomeric and tetrameric forms of the GAPDH molecule. GBS GAPDH was demonstrated by Western blot analysis to interact with lys- and glu-plasminogens. Fluid-phase GBS GAPDH interacted, by means of ELISA, with immobilized lys-plasminogen, glu-plasminogen, actin, and fibrinogen. Enzymatically active GAPDH, capable of binding cytoskeletal and extracellular matrix proteins, is expressed on the surface of GBS.Key words: group B streptococci, glyceraldehyde-3-phosphate dehydrogenase.

Neonatal infections caused by group B streptococci

1973 ◽  
Vol 116 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Dennis J. Hey ◽  
Robert T. Hall ◽  
V.F. Burry ◽  
A.N. Thurn
Keyword(s):  
Neonatal Infections ◽  
Group B Streptococci ◽  
Group B

scholarly journals Correction for Six et al., Molecular Characterization of Nonhemolytic and Nonpigmented Group B Streptococci Responsible for Human Invasive Infections

2016 ◽  
Vol 54 (7) ◽  
pp. 1932-1932
Author(s):  
Anne Six ◽  
Arnaud Firon ◽  
Céline Plainvert ◽  
Camille Caplain ◽  
Abdelouhab Bouaboud ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Group B Streptococci ◽  
Invasive Infections ◽  
Group B
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