Silver diamine fluoride with delayed restoration reduces tooth discoloration

Silver diamine fluoride (SDF) is used in minimally invasive dentistry for arresting dental caries. However, discoloration of teeth is a significant side effect that has limited the use of SDF. Hence, the application of potassium iodide (KI) following SDF has been proposed to ameliorate the staining. Although antimicrobial activity is one of the major mechanisms of the caries-arresting effect of SDF, the antimicrobial potency of SDF/KI combination is unclear. Thus, the primary objective of this systematic review was to appraise the studies on the antimicrobial efficacy of SDF/KI combination on cariogenic microbes. The secondary objective was to summarize the evidence on the potential of KI in reducing the discoloration associated with the application of SDF. Electronic databases of Medline via PubMed, Cochrane Library, Web of Science, and EBSCO host were searched for English language manuscripts from January 2005 to 15th November 2020. The reference lists of these manuscripts were manually searched for additional studies. Twelve studies were included in the final analysis, seven of which have investigated the antimicrobial efficacy of SDF/KI, and the rest have examined the anti-staining potential of KI. The exploratory findings from the reviewed articles revealed the promising antimicrobial potential of SDF/KI on cariogenic microbes associated with dentine caries. There is, however, contradictory evidence on the effect of SDF/KI on tooth color. The reviewed in-vitro studies indicated significant effectiveness of KI in preventing staining. A clinical trial on primary dentition showed 25% reduction in the incidence of staining by SDF after applying KI, while a clinical study on root caries in adults showed no significant effect. Within the methodological limitations of this review, we conclude that for arresting dental caries, SDF could be combined with KI, as there may be a lower likelihood of staining. Further, well-designed clinical trials on the antimicrobial and anti-staining effect of SDF/KI are needed to obtain more robust evidence.

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Comparative Evaluation of Effect of Potassium Iodide and Glutathione on Tooth Discoloration after Application of 38% Silver Diamine Fluoride in Primary Molars: An In Vitro Study

International Journal of Clinical Pediatric Dentistry ◽

10.5005/jp-journals-10005-2076 ◽

2021 ◽

Vol 14 (6) ◽

pp. 752-756

Author(s):

Aishwarya N Kamble ◽

Vamsi K Chimata ◽

Farhin A Katge ◽

Komal K Nanavati ◽

Shilpa K Shetty

Keyword(s):

Potassium Iodide ◽

Comparative Evaluation ◽

In Vitro Study ◽

Vitro Study ◽

Primary Molars ◽

Silver Diamine Fluoride ◽

Tooth Discoloration

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Efficacy of Silver Diamine Fluoride and Its Parental Perception

Case Medical Research ◽

10.31525/ct1-nct04213573 ◽

2019 ◽

Author(s):

Keyword(s):

Parental Perception ◽

Silver Diamine Fluoride

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Protective effect of titanium tetrafluoride and silver diamine fluoride on radiation-induced dentin caries in vitro

Scientific Reports ◽

10.1038/s41598-021-85748-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Beatriz Martines de Souza ◽

Mayara Souza Silva ◽

Aline Silva Braga ◽

Patrícia Sanches Kerges Bueno ◽

Paulo Sergio da Silva Santos ◽

...

Keyword(s):

Lactic Acid ◽

Protective Effect ◽

Acid Production ◽

Lactic Acid Production ◽

Negative Control ◽

Titanium Tetrafluoride ◽

Silver Diamine Fluoride ◽

Dentin Caries ◽

Radiation Induced

AbstractThis in vitro study evaluated the protective effect of titanium tetrafluoride (TiF4) varnish and silver diamine fluoride (SDF) solution on the radiation-induced dentin caries. Bovine root dentin samples were irradiated (70 Gy) and treated as follows: (6 h): 4% TiF4 varnish; 5.42% NaF varnish; 30% SDF solution; placebo varnish; or untreated (negative control). Microcosm biofilm was produced from human dental biofilm (from patients with head-neck cancer) mixed with McBain saliva for the first 8 h. After 16 h and from day 2 to day 5, McBain saliva (0.2% sucrose) was replaced daily (37 °C, 5% CO2) (biological triplicate). Demineralization was quantified by transverse microradiography (TMR), while biofilm was analyzed by using viability, colony-forming units (CFU) counting and lactic acid production assays. The data were statistically analyzed by ANOVA (p < 0.05). TiF4 and SDF were able to reduce mineral loss compared to placebo and the negative control. TiF4 and SDF significantly reduced the biofilm viability compared to negative control. TiF4 significantly reduced the CFU count of total microorganism, while only SDF affected total streptococci and mutans streptococci counts. The varnishes induced a reduction in lactic acid production compared to the negative control. TiF4 and SDF may be good alternatives to control the development of radiation-induced dentin caries.

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TOOTH DISCOLORATION AND TETRACYCLINES

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1972.tb108030.x ◽

1972 ◽

Vol 1 (19) ◽

pp. 954-955

Keyword(s):

Tooth Discoloration

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Tooth discoloration induced by apical plugs with hydraulic calcium silicate-based cements in teeth with open apices—a 2-year in vitro study

Clinical Oral Investigations ◽

10.1007/s00784-021-04009-0 ◽

2021 ◽

Author(s):

Ralf Krug ◽

C. Ortmann ◽

S. Reich ◽

B. Hahn ◽

G. Krastl ◽

...

Keyword(s):

Calcium Silicate ◽

In Vitro Study ◽

Color Difference ◽

Blood Contamination ◽

Tooth Color ◽

Color Changes ◽

Gutta Percha ◽

Tooth Discoloration ◽

Post Hoc

Abstract Objectives To assess tooth discoloration induced by different hydraulic calcium silicate-based cements (HCSCs), including effects of blood and placement method. Materials and methods Eighty bovine teeth cut to a length of 18 mm (crown 8 mm, root 10 mm) were randomly assigned to 10 groups (n = 8), receiving orthograde apical plug treatment (APT). Apical plugs were 4 mm in length and made of ProRoot MTA (Dentsply), Medcem MTA (Medcem), TotalFill BC RRM Fast Set Putty (Brasseler), or Medcem Medical Portland Cement (Medcem) plus bismuth oxide (Bi2O3) with and without bovine blood. Further, orthograde (with or without preoperative adhesive coronal dentin sealing) and retrograde APT were compared. Teeth were obturated with gutta-percha and sealer, sealed with composite and stored in distilled water. Tooth color was measured on apical plug, gutta-percha/sealer, and crown surface before treatment versus 24 h, 1, 3, 6, 12, and 24 months after treatment by spectrophotometry. Color difference (ΔE) values were calculated and analyzed by Shapiro–Wilk test, ANOVA with post hoc tests, Friedman test, t test, and post hoc tests with Bonferroni correction (α = .05). Results Tooth discoloration occurred in all groups with no significant differences between HCSCs (p > .05). After 24 months, color changes were prominent on roots but insignificant on crowns. Blood contamination induced a significantly decreased luminescence (p < .05). Blood had a stronger impact on tooth color than Bi2O3. No relevant effects of retrograde placement (p > .05) or preoperative dentin sealing (p > .05) were detected. Conclusions Apical plugs of the tested HCSCs cause discoloration of bovine roots, but not discoloration of bovine tooth crowns within a 24-month period. Clinical relevance APT should be performed carefully while avoiding direct contact with the coronal dentin, and in that case no aesthetic impairments occur.

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