No effect of different bariatric surgery procedures on LINE-1 DNA methylation in diabetic and nondiabetic morbidly obese patients

2017 ◽  
Vol 13 (3) ◽  
pp. 442-450 ◽  
Author(s):  
G.M. Martín-Núñez ◽  
A. Cabrera-Mulero ◽  
J. Alcaide-Torres ◽  
E. García-Fuentes ◽  
F.J. Tinahones ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Dna Methylation ◽  
Morbidly Obese ◽  
Obese Patients ◽  
On Line

scholarly journals Changes in SCD gene DNA methylation after bariatric surgery in morbidly obese patients are associated with free fatty acids

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Sonsoles Morcillo ◽  
Gracia Mª Martín-Núñez ◽  
Sara García-Serrano ◽  
Carolina Gutierrez-Repiso ◽  
Francisca Rodriguez-Pacheco ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Dna Methylation ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Morbidly Obese ◽  
Obese Patients

Improvement in Obstructive Sleep Apnea (OSA) in Super Morbidly Obese Patients After Bariatric Surgery

2020 ◽  
Vol 103 (8) ◽  
pp. 725-728
Keyword(s):  
Bariatric Surgery ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Lifestyle Modification ◽  
Apnea Hypopnea Index ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Obstructive Sleep ◽  
Objective Evidence

Background: Lifestyle modification is the mainstay therapy for obese patients with obstructive sleep apnea (OSA). However, most of these patients are unable to lose the necessary weight, and bariatric surgery (BS) has been proven to be an effective modality in selected cases. Objective: To provide objective evidence that BS can improve OSA severity. Materials and Methods: A prospective study was conducted in super morbidly obese patients (body mass index [BMI] greater than 40 kg/m² or BMI greater than 35 kg/m² with uncontrolled comorbidities) scheduled for BS. Polysomnography (PSG) was performed for preoperative assessment and OSA was treated accordingly. After successful surgery, patients were invited to perform follow-up PSG at 3, 6, and 12 months. Results: Twenty-four patients with a mean age of 35.0±14.0 years were enrolled. After a mean follow-up period of 7.8±3.4 months, the mean BMI, Epworth sleepiness scale (ESS), and apnea-hypopnea index (AHI) significantly decreased from 51.6±8.7 to 38.2±6.8 kg/m² (p<0.001), from 8.7±5.9 to 4.7±3.5 (p=0.003), and from 87.6±38.9 to 28.5±21.5 events/hour (p<0.001), respectively. Conclusion: BS was shown to dramatically improve clinical and sleep parameters in super morbidly obese patients. Keywords: Morbid obesity, Bariatric surgery, Obstructive sleep apnea (OSA)

scholarly journals Endovascular Bariatric Surgery as Novel Minimally Invasive Technique for Weight Management in the Morbidly Obese: Review of the Literature

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2541
Author(s):  
Giuseppe Massimo Sangiorgi ◽  
Alberto Cereda ◽  
Nicola Porchetta ◽  
Daniela Benedetto ◽  
Andrea Matteucci ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Minimally Invasive ◽  
Weight Management ◽  
World Health ◽  
Invasive Technique ◽  
Morbidly Obese ◽  
World Population ◽  
Obese Patients ◽  
The World ◽  
Open Bariatric Surgery

Nowadays, obesity represents one of the most unresolved global pandemics, posing a critical health issue in developed countries. According to the World Health Organization, its prevalence has tripled since 1975, reaching a prevalence of 13% of the world population in 2016. Indeed, as obesity increases worldwide, novel strategies to fight this condition are of the utmost importance to reduce obese-related morbidity and overall mortality related to its complications. Early experimental and initial clinical data have suggested that endovascular bariatric surgery (EBS) may be a promising technique to reduce weight and hormonal imbalance in the obese population. Compared to open bariatric surgery and minimally invasive surgery (MIS), EBS is much less invasive, well tolerated, with a shorter recovery time, and is probably cost-saving. However, there are still several technical aspects to investigate before EBS can be routinely offered to all obese patients. Further prospective studies and eventually a randomized trial comparing open bariatric surgery vs. EBS are needed, powered for clinically relevant outcomes, and with adequate follow-up. Yet, EBS may already appear as an appealing alternative treatment for weight management and cardiovascular prevention in morbidly obese patients at high surgical risk.

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