Lucinéia Orsolin Pfeifer
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Angélica Trevisan De Nardi
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Larissa Xavier Neves da Silva
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Daniela Meirelles do Nascimento
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Cíntia Ehlers Botton
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Background: Type 2 diabetes mellitus (T2DM) is a growing health problem, with increasing proportions in the world population, with a higher prevalence in older people. This age group is also quite affected by reductions in functional performance, which seems to be more pronounced in patients with T2DM. Therefore, we aimed to summarize the potential changes (if any) in the functional capacity of middle-aged adults and older individuals with T2DM whoparticipate in structured physical activity interventions.Methods: This article protocol is reported based on the PRISMA-P recommendations. Comprehensive searches of the PubMed (via website), PEDro Physiotherapy EvidenceDatabase (via website), Cochrane Library (via website), SportDiscus (via Periódicos CAPES), and Lilacs (via BVS). Open Grey and Google Scholar for grey literature will be completed using the following keywords: aging, diabetes, exercise therapy, and related entry terms. Studies tobe included should consist of randomized controlled trials or non-randomized controlled studies in English, Spanish or Portuguese, with T2DM participants, of any gender, with an average age of 45 years or older; interventions with structured physical activity; with measurements of predefined outcomes of functional capacity. Relevant data will be extracted in duplicate using a customized data extraction sheet. The risk of bias of the included studies will be assessed in duplicate using the Checklist DOWNS & BLACK. If possible, with the permitted numeric data, we will carry out a meta-analysis using a random effects model (with a 95% confidence interval). Subgroup and sensitivity and meta-regression analyses will be carried out if possible. The review will be mostly based on the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions, Version 6.1.Discussion: This systematic review aims to provide a high-quality synthesis regarding the effects of structured exercise programs on the functional capacity of middle-aged adults and older individuals with T2DM. This review may refine clinical recommendations that are still generic for the older population with T2DM.