Aiming at the design and development of integrated Manufacturing Execution System (MES) of solar photovoltaic modules production, the difficulty of the manufacturing execution management was pointed out combining with solar photovoltaic modules production flow, the goals and main functions of the integrated MES were analyzed and designed based on the analysis of solar photovoltaic modules production enterprise’s main characteristics and management status. The physical data model of MES was designed by Power Designer software and some key function modules which include workshop plans and scheduling management, Workflow management and control system and process quality control were developed based on J2EE. The practical applications in some solar photovoltaic modules production enterprises were proved that the integrated MES could enhance the manufacturing management level of solar photovoltaic modules production effectively.