Soft Tissue Sarcomas: Current Management and Future Directions

2009 ◽  
Vol 89 (1) ◽  
pp. 235-247 ◽  
Author(s):  
Robert J. Kenney ◽  
Richard Cheney ◽  
Margaret A. Stull ◽  
William Kraybill
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Current Management ◽  
Future Directions

scholarly journals Toward a Personalized Therapy in Soft-Tissue Sarcomas: State of the Art and Future Directions

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2359
Author(s):  
Liliana Montella ◽  
Lucia Altucci ◽  
Federica Sarno ◽  
Carlo Buonerba ◽  
Stefano De Simone ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Chromosomal Translocations ◽  
Intrinsic Variability ◽  
Poor Survival ◽  
Genomic Alterations ◽  
Future Directions ◽  
Oncogenic Mutations ◽  
Targeted Treatments ◽  
Innovative Therapies

Soft-tissue sarcomas are rare tumors characterized by pathogenetic, morphological, and clinical intrinsic variability. Median survival of patients with advanced tumors are usually chemo- and radio-resistant, and standard treatments yield low response rates and poor survival results. The identification of defined genomic alterations in sarcoma could represent the premise for targeted treatments. Summarizing, soft-tissue sarcomas can be differentiated into histotypes with reciprocal chromosomal translocations, with defined oncogenic mutations and complex karyotypes. If the latter are improbably approached with targeted treatments, many suggest that innovative therapies interfering with the identified fusion oncoproteins and altered pathways could be potentially resolutive. In most cases, the characteristic genetic signature is discouragingly defined as “undruggable”, which poses a challenge for the development of novel pharmacological approaches. In this review, a summary of genomic alterations recognized in most common soft-tissue sarcoma is reported together with current and future therapeutic opportunities.

Current Management of Neonatal Soft-tissue Sarcomas and Benign Tumors with Local Aggressiveness

2015 ◽  
Vol 11 (3) ◽  
pp. 216-225 ◽  
Author(s):  
Israel Fernandez-Pineda ◽  
Michael D. Neel ◽  
Bhaskar N. Rao
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Benign Tumors ◽  
Current Management
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