Distribution of lymph node metastasis is a prognostic index in patients with stage III colon cancer

Surgery ◽  
2006 ◽  
Vol 139 (4) ◽  
pp. 516-522 ◽  
Author(s):  
Hirotoshi Kobayashi ◽  
Hideki Ueno ◽  
Yojiro Hashiguchi ◽  
Hidetaka Mochizuki
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Prognostic Index ◽  
Stage Iii ◽  
Stage Iii Colon Cancer ◽  
Node Metastasis

Prognostic Significance of Tumor Deposits in Combination with Lymph Node Metastasis in Stage III Colon Cancer: A Propensity Score Matching Study

2020 ◽  
Vol 86 (2) ◽  
pp. 164-170
Author(s):  
Peilin Zheng ◽  
Chen Lai ◽  
Weimin Yang ◽  
Zhikang Chen
Keyword(s):  
Colon Cancer ◽  
Overall Survival ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Propensity Score ◽  
Confidence Interval ◽  
Propensity Score Matching ◽  
Stage Iii ◽  
Stage Iii Colon Cancer ◽  
Node Metastasis

Tumor deposits in colon cancer are related to poor prognosis, whereas the prognostic power of tumor deposits in combination with lymph node metastasis (LNM) is controversial. This study aimed to compare the overall survival between LNM alone and LNM in combination with tumor deposits, and to verify whether the number of tumor deposits can be considered LNM in patients with both LNM and tumor deposits in stage III colon cancer by propensity score matching (PSM). Patients carrying resected stage III adenocarcinoma of colon cancer were identified from the Surveillance, Epidemiology, and End Results database (2010–2015). The Kaplan-Meier method, Cox proportional hazard models and PSM were used. On the whole, 23,168 patients (20,451 (88.3%) with only LNM and 2,717 (11.7%) with both LNM and tumor deposits) were selected. After undergoing PSM, patients with both LNM and tumor deposits showed worse overall survival (hazard ratio = 1.33, 95% confidence interval: 1.20–1.47, P < 0.001). After the number of tumor deposits was added with that of positive regional lymph nodes, patients with both LNM and tumor deposits seemed to have prognostic implications similar to those with LNM alone (hazard ratio = 1.02, 95% confidence interval: 0.93–1.12, P = 0.66). The simultaneous presence of LNM and tumor deposits, as compared with the presence of only LNM, had an association with a worse outcome. Tumor deposits should be considered as LNM in patients with both tumor deposits and LNM in stage III colon cancer.

scholarly journals Grading, staging and Nottingham prognostic index scoring of breast carcinoma

2017 ◽  
Vol 7 (1) ◽  
pp. 1078-1083
Author(s):  
A Pradhan ◽  
P Paudyal ◽  
AK Sinha ◽  
CS Agrawal
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Lymph Node Metastasis ◽  
Prognostic Index ◽  
Nottingham Prognostic Index ◽  
Eastern Region ◽  
Axillary Lymph ◽  
Cross Sectional ◽  
Tnm System ◽  
Node Metastasis

Background: Breast carcinoma is the most frequent malignant tumor in women accounting for approximately 15% of female cancer deaths. It is the second most common malignancy among women in Nepal. Our objectives were to study the extent and spread of different histological types breast carcinoma in the eastern region of Nepal, to grade and stage the tumors, score the prognosis.Materials and Methods: A cross-sectional descriptive study of mastectomy specimens with axillary lymph node sampling was done for a period of two years. Diagnosis was done using WHO classification. Modified Bloom Richardson score and TNM system was used to grade and stage the tumors. Nottingham Prognostic index was applied to score the prognosis.Results: Out of 31 total cases, the most common histologic type was Invasive Carcinoma of No Special Type (67.74%). The largest tumor size was of 12cm which had poor NPI score. Most tumors were of grade II and T2. Out of 30 cases with lymph nodes, 13 were negative for metastasis pN0, 10 were pN1 and 7 were pN2. Extranodal spread was observed in 6 out of 17 cases with lymph node metastasis and was associated with higher grades and poor prognosis.Conclusion: Higher grade tumors, lymph node metastasis and extranodal extension are associated with higher Nottingham Prognostic Index score. 

scholarly journals A Case of Early Sigmoid Colon Cancer with Micropapillary Carcinoma Component with Lymph Node Metastasis

2020 ◽  
Vol 73 (5) ◽  
pp. 202-208
Author(s):  
Hiroyuki Ozasa ◽  
Yasumi Araki ◽  
Toshihiro Noake ◽  
Keiko Matono ◽  
Masato Iwami ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Sigmoid Colon ◽  
Sigmoid Colon Cancer ◽  
Micropapillary Carcinoma ◽  
Node Metastasis

scholarly journals Axillary Lymph Node Metastasis of Colon Cancer—Case Report and Literature Review

2014 ◽  
Vol 03 (12) ◽  
pp. 669-673
Author(s):  
Helena Devesa ◽  
Luísa Pereira ◽  
Álvaro Gonçalves ◽  
Telma Brito ◽  
Teresa Almeida ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Case Report ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Literature Review ◽  
Axillary Lymph Node ◽  
Axillary Lymph Node Metastasis ◽  
Cancer Case ◽  
Axillary Lymph ◽  
Node Metastasis

scholarly journals Preoperative Predictors of Lymph Node Metastasis in Colon Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Yansong Xu ◽  
Yi Chen ◽  
Chenyan Long ◽  
Huage Zhong ◽  
Fangfang Liang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Logistic Regression ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Multivariate Logistic Regression Analysis ◽  
Multivariate Logistic Regression ◽  
Node Metastasis ◽  
Logistic Analysis ◽  
Primary Colon Cancer ◽  
Primary Colon

BackgroundLymph node metastasis (LNM) is a well-established prognostic factor for colon cancer. Preoperative LNM evaluation is relevant for planning colon cancer treatment. The aim of this study was to construct and evaluate a nomogram for predicting LNM in primary colon cancer according to pathological features.Patients and MethodsSix-hundred patients with clinicopathologically confirmed colon cancer (481 cases in the training set and 119 cases in the validation set) were enrolled in the Affiliated Cancer Hospital of Guangxi Medical University from January 2010 to December 2019. The expression of molecular markers (p53 and β-catenin) was determined by immunohistochemistry. Multivariate logistic regression was used to screen out independent risk factors, and a nomogram was established. The accuracy and discriminability of the nomogram were evaluated by consistency index and calibration curve.ResultsUnivariate logistic analysis revealed that LNM in colon cancer is significantly correlated (P &lt;0.05) with tumor size, grading, stage, preoperative carcinoembryonic antigen (CEA) level, and peripheral nerve infiltration (PNI). Multivariate logistic regression analysis confirmed that CEA, grading, and PNI were independent prognostic factors of LNM (P &lt;0.05). The nomogram for predicting LNM risk showed acceptable consistency and calibration capability in the training and validation sets.ConclusionsPreoperative CEA level, grading, and PNI were independent risk factor for LNM. Based on the present parameters, the constructed prediction model of LNM has potential application value.

scholarly journals Extent of D2 Surgery for Colon Cancer According to Tumor Location with Respect to Vascular Anatomy and Lymph Node Metastasis.

1996 ◽  
Vol 29 (3) ◽  
pp. 710-716
Author(s):  
Hirokazu Yada ◽  
Kiyoshi Sawai ◽  
Miyakatsu Ohara ◽  
Masataka Shimotsuma ◽  
Hiroki Taniguchi ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Vascular Anatomy ◽  
Tumor Location ◽  
Node Metastasis ◽  
D2 Surgery
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