scholarly journals 2,3,7,8-Tetrachlorodibenzo-p-dioxin activates the aryl hydrocarbon receptor and alters sex steroid hormone secretion without affecting growth of mouse antral follicles in vitro

2012 ◽  
Vol 261 (1) ◽  
pp. 88-96 ◽  
Author(s):  
Bethany N. Karman ◽  
Mallikarjuna S. Basavarajappa ◽  
Zelieann R. Craig ◽  
Jodi A. Flaws
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Steroid Hormone ◽  
Hormone Secretion ◽  
Sex Steroid ◽  
Sex Steroid Hormone ◽  
Antral Follicles ◽  
Aryl Hydrocarbon ◽  
Tetrachlorodibenzo P Dioxin

Sex steroid hormone secretion in the wall lizardPodarcis siculatestis: The involvement of VIP

2015 ◽  
Vol 323 (10) ◽  
pp. 714-721 ◽  
Author(s):  
Luigi Rosati ◽  
Marina Prisco ◽  
Maria Maddalena Di Fiore ◽  
Alessandra Santillo ◽  
Rosaria Sciarrillo ◽  
...  
Keyword(s):  
Steroid Hormone ◽  
Hormone Secretion ◽  
Sex Steroid ◽  
Sex Steroid Hormone

scholarly journals Sex differences in viral entry protein expression, host responses to SARS-CoV-2, and in vitro responses to sex steroid hormone treatment in COVID-19

2020 ◽  
Author(s):  
Mengying Sun ◽  
Rama Shankar ◽  
Meehyun Ko ◽  
Christopher Daniel Chang ◽  
Shan-Ju Yeh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sex Differences ◽  
Steroid Hormone ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Hormone Treatment ◽  
Host Responses ◽  
Sex Steroid ◽  
Sex Steroid Hormone

Abstract Epidemiological studies suggest that men exhibit a higher mortality rate to COVID-19 than women, yet the underlying biology is largely unknown. Here, we seek to delineate sex differences in the expression of entry genes ACE2 and TMPRSS2, host responses to SARS-CoV-2, and in vitro responses to sex steroid hormone treatment. Using over 220,000 human gene expression profiles covering a wide range of age, tissues, and diseases, we found that male samples show higher expression levels of ACE2 and TMPRSS2, especially in the older group (>60 years) and in the kidney. Analysis of 6,031 COVID-19 patients at Mount Sinai Health System revealed that men have significantly higher creatinine levels, an indicator of impaired kidney function. Further analysis of 782 COVID-19 patient gene expression profiles taken from upper airway and blood suggested men and women present profound expression differences in responses to SARS-CoV-2. Computational deconvolution analysis of these profiles revealed male COVID-19 patients have enriched kidney-specific mesangial cells in blood compared to healthy patients. Finally, we observed selective estrogen receptor modulators, but not other hormone drugs (agonists/antagonists of estrogen, androgen, and progesterone), could reduce SARS-CoV-2 infection in vitro.

Sex Steroid Hormone Receptors and Human Gallbladder Motility in vitro

Digestion ◽  
1990 ◽  
Vol 46 (4) ◽  
pp. 214-219 ◽  
Author(s):  
C. Messa ◽  
M.A. Maselli ◽  
A. Cavallini ◽  
M.L. Caruso ◽  
F. Pezzolla ◽  
...  
Keyword(s):  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
Gallbladder Motility ◽  
Sex Steroid ◽  
Human Gallbladder ◽  
Sex Steroid Hormone
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