The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds

2012 ◽  
Vol 263 (2) ◽  
pp. 171-183 ◽  
Author(s):  
Louise Marks ◽  
Samantha Borland ◽  
Karen Philp ◽  
Lorna Ewart ◽  
Pierre Lainée ◽  
...  
Author(s):  
Adithya J ◽  
Bhagyalakshmi Nair ◽  
Aishwarya S ◽  
Lekshmi R. Nath

: SARS-CoV 2 is a novel virus strain of Coronavirus, reported in China in late December 2019. Its highly contagious nature in humans has prompted WHO to designate the ongoing pandemic as a Public Health Emergency of International Concern. At this moment, there is no specific treatment and the therapeutic strategies to deal with the infection are only supportive, and prevention aimed at reducing community transmission. A permanent solution for the pandemic, which has brought the world economy to the edge of collapse, is the need of the hour. This situation has brought intense research in traditional systems of medicine. Indian Traditional System, Ayurveda has a clear concept of the cause and treatment of pandemics. Through this review, information on the potential antiviral traditional medicines along with their immunomodulatory pathways is discussed. We have covered the seven most important Indian traditional plants with antiviral properties :Withaniasomnifera (L.) Dunal(family: Solanaceae),Tinosporacordifolia(Thunb.)Miers (family:Menispermaceae),Phyllanthusemblica L.(family:Euphorbiaceae),Asparagus racemosus L.(family:Liliaceae), Glycyrrhizaglabra L.(family:Fabaceae), Ocimum sanctum L.(family:Lamiaceae) and Azadirachta indica A.Juss(family:Meliaceae)in this review. An attempt is also made to bring into limelight the importance of dietary polyphenol, Quercetin which is a potential drug candidate in the making against the SARS-CoV2 virus.


2005 ◽  
Vol 566 (1) ◽  
pp. 205-212 ◽  
Author(s):  
Min-Goo Lee ◽  
Donald W. MacGlashan ◽  
Bradley J. Undem
Keyword(s):  

2000 ◽  
Vol 129 (6) ◽  
pp. 1103-1112 ◽  
Author(s):  
J -F Quignard ◽  
M Félétou ◽  
G Edwards ◽  
J Duhault ◽  
A H Weston ◽  
...  

Hepatology ◽  
1990 ◽  
Vol 11 (5) ◽  
pp. 843-849 ◽  
Author(s):  
Hernan Speisky ◽  
Nick Shackel ◽  
George Varghese ◽  
Denis Wade ◽  
Yedy Israel
Keyword(s):  

1975 ◽  
Vol 34 (1) ◽  
pp. 39-47 ◽  
Author(s):  
William J. Hall ◽  
Padraic O'Neill ◽  
John D. Sheehan

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