scholarly journals Grape seed proanthocyanidins reactivate silenced tumor suppressor genes in human skin cancer cells by targeting epigenetic regulators

2012 ◽  
Vol 263 (1) ◽  
pp. 122-130 ◽  
Author(s):  
Mudit Vaid ◽  
Ram Prasad ◽  
Tripti Singh ◽  
Virginia Jones ◽  
Santosh K. Katiyar
Keyword(s):  
Skin Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Human Skin ◽  
Tumor Suppressor Genes ◽  
Grape Seed ◽  
Suppressor Genes ◽  
Grape Seed Proanthocyanidins ◽  
Epigenetic Regulators

Up-regulation of tumor suppressor genes might promote the malignant phenotype of cancer cells

2007 ◽  
Vol 69 (6) ◽  
pp. 1379 ◽  
Author(s):  
Liu Hong ◽  
Xiaohua Li ◽  
Haifeng Jin ◽  
Li Yan ◽  
Kaichun Wu ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Genes ◽  
Malignant Phenotype ◽  
Suppressor Genes

scholarly journals Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms

2019 ◽  
Vol 12 ◽  
pp. 251686571983901 ◽  
Author(s):  
Shahad A Qadi ◽  
Mohammed A Hassan ◽  
Ryan A Sheikh ◽  
Othman AS Baothman ◽  
Mazin A Zamzami ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Cell Line ◽  
Rna Sequencing ◽  
Cancer Cell ◽  
Tumor Suppressor Genes ◽  
Jurkat Cells ◽  
Leukemia Cell Line ◽  
Suppressor Genes

The epigenetic silencing of tumor suppressor genes (TSGs) is a common finding in several solid and hematological tumors involving various epigenetic readers and writers leading to enhanced cell proliferation and defective apoptosis. Thymoquinone (TQ), the major biologically active compound of black seed oil, has demonstrated anticancer activities in various tumors by targeting several pathways. However, its effects on the epigenetic code of cancer cells are largely unknown. In the present study, we performed RNA sequencing to investigate the anticancer mechanisms of TQ-treated T-cell acute lymphoblastic leukemia cell line (Jurkat cells) and examined gene expression using different tools. We found that many key epigenetic players, including ubiquitin-like containing plant homeodomain (PHD) and really interesting new gene (RING) finger domains 1 ( UHRF1), DNMT1,3A,3B, G9A, HDAC1,4,9, KDM1B, and KMT2A,B,C,D,E, were downregulated in TQ-treated Jurkat cells. Interestingly, several TSGs, such as DLC1, PPARG, ST7, FOXO6, TET2, CYP1B1, SALL4, and DDIT3, known to be epigenetically silenced in various tumors, including acute leukemia, were upregulated, along with the upregulation of several downstream pro-apoptotic genes, such as RASL11B, RASD1, GNG3, BAD, and BIK. Data obtained from RNA sequencing were confirmed using quantitative reverse transcription polymerase chain reaction (RT-qPCR) in Jurkat cells, as well as in a human breast cancer cell line (MDA-MB-468 cells). We found that the decrease in cell proliferation and in the expression of UHRF1, DNMT1, G9a, and HDAC1 genes in both cancer cell (Jurkat cells and MDA-MB-468 cells) lines depends on the TQ dose. Our results indicate that the use of TQ as an epigenetic drug represents a promising strategy for epigenetic therapy for both solid and blood tumors by targeting both DNA methylation and histone post-translational modifications.

scholarly journals KMT2D inhibits the growth and metastasis of bladder Cancer cells by maintaining the tumor suppressor genes

2019 ◽  
Vol 115 ◽  
pp. 108924 ◽  
Author(s):  
Peng Sun ◽  
Tong Wu ◽  
Xiaoliang Sun ◽  
Zilian Cui ◽  
Haiyang Zhang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Genes ◽  
Suppressor Genes ◽  
Bladder Cancer Cells

scholarly journals Cancer cell-selective killing polymer/copper combination

2016 ◽  
Vol 4 (1) ◽  
pp. 115-120 ◽  
Author(s):  
Huacheng He ◽  
Diego Altomare ◽  
Ufuk Ozer ◽  
Hanwen Xu ◽  
Kim Creek ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Tumor Suppressor Genes ◽  
Glutathione Level ◽  
Suppressor Genes

A polymer/copper combination selectively kills cancer cells by targeting their high glutathione level, upregulated oncogenes, and downregulated tumor suppressor genes.

scholarly journals Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells

Oncogene ◽  
2006 ◽  
Vol 26 (20) ◽  
pp. 2873-2884 ◽  
Author(s):  
I Ivanov ◽  
K C Lo ◽  
L Hawthorn ◽  
J K Cowell ◽  
Y Ionov
Keyword(s):  
Colon Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Genes ◽  
Mrna Decay ◽  
Colon Cancer Cells ◽  
Suppressor Genes ◽  
Cancer Tumor ◽  
Nonsense Mediated Mrna Decay

scholarly journals PKG induces the expression of tumor suppressor genes in colon cancer cells

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Hassan Sellak ◽  
Songwei Wu ◽  
Thomas M. Lincoln
Keyword(s):  
Colon Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Genes ◽  
Colon Cancer Cells ◽  
Suppressor Genes

scholarly journals REVERSAL OF HYPERMETHYLATION AND REACTIVATION OF TUMOR SUPPRESSOR GENES DUE TO NATURAL COMPOUNDS IN BREAST CANCER CELLS

2020 ◽  
Vol 02 (01) ◽  
pp. 63-75
Author(s):  
Debasray Saha ◽  
Neeraj Vaishnav ◽  
Zubiya Ahsan ◽  
Nisha Rani ◽  
Runjhun Mathur ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Genes ◽  
Breast Cancer Cells ◽  
Natural Compounds ◽  
Suppressor Genes
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