A rapid UPLC–MS/MS method for simultaneous determination of flunitrazepam, 7-aminoflunitrazepam, methadone and EDDP in human, rat and rabbit plasma

Talanta ◽  
2012 ◽  
Vol 99 ◽  
pp. 649-659 ◽  
Author(s):  
Béla Kiss ◽  
Catalina Bogdan ◽  
Anca Pop ◽  
Felicia Loghin
Keyword(s):  
Simultaneous Determination ◽  
Rabbit Plasma

Simultaneous determination of a new antituberculosis agent KBF-611 and its de-acetylated metabolite in mouse and rabbit plasma by HPLC

2009 ◽  
Vol 32 (10) ◽  
pp. 1453-1460 ◽  
Author(s):  
Farhad Mostafavi Shahab ◽  
Farzad Kobarfard ◽  
Simin Dadashzadeh
Keyword(s):  
Simultaneous Determination ◽  
Rabbit Plasma

scholarly journals TLC-spectrodensitometric method for simultaneous determination of dapagliflozin and rosuvastatin in rabbit plasma: stability indicating assay and kinetic studies

RSC Advances ◽  
2020 ◽  
Vol 10 (67) ◽  
pp. 40795-40805
Author(s):  
Noha S. Abbas ◽  
Sayed M. Derayea ◽  
Mahmoud A. Omar ◽  
Gamal A. Saleh
Keyword(s):  
Ethyl Acetate ◽  
Simultaneous Determination ◽  
Mobile Phase ◽  
Kinetic Studies ◽  
Urine Samples ◽  
Plasma Stability ◽  
Rabbit Plasma ◽  
Stability Indicating ◽  
Plasma And Urine Samples

Mixtures of DAPA and ROSV were separated using ethyl acetate : methanol (5 : 0.1 v/v) as mobile phase and applied in plasma and urine samples in addition to stability indicating and kinetic studies.

New, simple and sensitive HPTLC method for simultaneous determination of anti-hepatitis C sofosbuvir and ledipasvir in rabbit plasma

2018 ◽  
Vol 1092 ◽  
pp. 432-439 ◽  
Author(s):  
Samia M. El-Gizawy ◽  
Salwa R. El-Shaboury ◽  
Noha N. Atia ◽  
Mohammad Nabil Abo-Zeid
Keyword(s):  
Hepatitis C ◽  
Simultaneous Determination ◽  
Rabbit Plasma ◽  
Hptlc Method

scholarly journals Bioanalytical Method Development and Validation for the Simultaneous Determination of Vildagliptin and Telmisartan in Rabbit Plasma Using RP-HPLC

2021 ◽  
pp. 76-86
Author(s):  
Budideti Kishore Kumar Reddy ◽  
Kothapalli Bonnoth Chandra Sekhar ◽  
Chinnala Krishna Mohan
Keyword(s):  
Simultaneous Determination ◽  
Method Development ◽  
Extraction Procedure ◽  
Methyl Tert Butyl Ether ◽  
Isosbestic Point ◽  
Therapeutic Drug ◽  
Rabbit Plasma ◽  
Butyl Ether ◽  
Bioanalytical Method

A simple, reproducible bioanalytical method of liquid chromatography and PDA detector was developed and validated for the simultaneous Determination of Vildagliptin and Telmisartan in Rabbit Plasma using liquid-liquid extraction technique. K2 EDTA was used as anti-coagulant. Analytes were extracted by Methyl-tert-Butyl Ether (MTBE) and subsequent separation on a Kromasil C18 column (5 µ, 100 × 4.6 mm) using Acetonitrile : Methanol 75:25 v/v as mobile phase at a flow rate of 1 mL/min and (40±1)°C column oven temperature. Analytes were monitored with PDA detector at an isosbestic point of 225 nm for both Vildagliptin and Telmisartan.  Retention times of Vildagliptin and Telmisartan were found to be at 2.545 mins and 6.633 mins respectively. The method was validated over a linear (r2 = 0.9979) concentration range of 24.979 - 5003.808  µg/ml for Vildagliptin and 1.011- 202.559 µg/ml for Telmisartan. The inter-day and intra-day precisions were found to be less than 15% and the accuracy was all within ±15% (at LLOQ ±20%). The developed HPLC-PDA method was fully validated for all the other parameters as per FDA guidelines like selectivity, matrix effect, recovery and stability as well. Due to the high degree of sensitivity, very less time consuming, easy extraction procedure and low requirement of sample volume, the method will be applicable for therapeutic drug monitoring.

Simultaneous Determination of Pethidine and Atropine in Rabbit Plasma by LC–MS–MS and Its Application to a Pharmacokinetic Study after Intramuscular Administration

2011 ◽  
Vol 73 (11-12) ◽  
pp. 1197-1202 ◽  
Author(s):  
Chan Chen ◽  
Jie Deng ◽  
Shougang Wang ◽  
Jiejin Zhu ◽  
Meifei Lu ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Pharmacokinetic Study ◽  
Intramuscular Administration ◽  
Rabbit Plasma

scholarly journals Sensitive Liquid Chromatographic Assay for Simultaneous Determination of Olmesartan and Its Prodrug Olmesartan Medoxomil in Rabbit Plasma

2014 ◽  
Vol 26 (12) ◽  
pp. 3530-3534 ◽  
Author(s):  
T. Sharma ◽  
S.K. Moitra ◽  
D. Gowrisankar ◽  
S.C. Si
Keyword(s):  
Simultaneous Determination ◽  
Olmesartan Medoxomil ◽  
Rabbit Plasma ◽  
Liquid Chromatographic
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