Dispersive liquid–liquid microextraction followed by high-performance liquid chromatography for determination of benzoate and sorbate in yogurt drinks and method optimization by central composite design

Talanta ◽  
2013 ◽  
Vol 109 ◽  
pp. 46-51 ◽  
Author(s):  
Marzieh Kamankesh ◽  
Abdorreza Mohammadi ◽  
Zohreh Modarres Tehrani ◽  
Roohallah Ferdowsi ◽  
Hedayat Hosseini
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Central Composite Design ◽  
High Performance ◽  
Method Optimization ◽  
Dispersive Liquid Liquid Microextraction ◽  
Central Composite ◽  
Liquid Microextraction

A simple, effective and highly sensitive analytical method used for the determination of caffeine in tea and energy drink samples, and method optimization using a central composite design

2017 ◽  
Vol 9 (10) ◽  
pp. 1665-1671 ◽  
Author(s):  
Samira Yousefi ◽  
Marzieh Kamankesh ◽  
Sahar Jazaeri ◽  
Abdolmohammad Attaran ◽  
Abdorreza Mohammadi
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Central Composite Design ◽  
Analytical Method ◽  
High Performance ◽  
Energy Drink ◽  
Highly Sensitive ◽  
Method Optimization ◽  
Central Composite

A rapid, simple and highly sensitive analytical method based on a microextraction method, followed by high-performance liquid chromatography was developed for the determination of caffeine in different tea and energy drink samples.

Determination of Verapamil in Exhaled Breath Condensate by Using Microextraction and Liquid Chromatography

2019 ◽  
Vol 15 (5) ◽  
pp. 535-541 ◽  
Author(s):  
Fariba Pourkarim ◽  
Ali Shayanfar ◽  
Maryam Khoubnasabjafari ◽  
Fariborz Akbarzadeh ◽  
Sanaz Sajedi-Amin ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Good Precision ◽  
Dispersive Liquid Liquid Microextraction ◽  
Breath Condensate ◽  
Liquid Microextraction

Background:Developing a simple analysis method for quantification of drug concentration is one of the essential issues in pharmacokinetic and therapeutic drug monitoring studies.Objective:A fast and reliable dispersive liquid-liquid microextraction procedure was employed for preconcentration of verapamil in exhaled breath condensate (EBC) samples and this was followed by the determination with high-performance liquid chromatography-ultraviolet detection.Methods:A reverse-phase high-performance liquid chromatography (RP-HPLC) combined with a dispersive liquid-liquid microextraction method (DLLME) was applied for quantification of verapamil in the EBC samples. The developed method was validated according to FDA guidelines.Results:Under the optimum conditions, the method provided a linear range between 0.07 and 0.8 µg.mL-1 with a coefficient of determination of 0.998. The intra- and inter-day relative standard deviation and relative error values of the method were below 15%, which indicated good precision and accuracy. The proposed method was successfully applied for the analysis of verapamil in two real samples with concentrations of 0.07 and 0.09 µg.mL-1.Conclusion:The established HPLC-UV-DLLME method could be applied for the analysis of verapamil in human EBC samples.

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