Development of multicolor carbon nanoparticles for cell imaging

Nanoscale carbon particles have emerged as versatile precursors for a new class of highly fluorescent nanomaterials that resemble semiconductor quantum dots. The surface-passivated fluorescent carbon nanoparticles, dubbed ‘carbon dots’, were already demonstrated for their potential optical bioimaging applications in vitro and in vivo. In this study, we conducted a systematic cytotoxicity evaluation on the carbon dots prepared by various combinations of precursor carbon nanoparticles and molecules for the particle surface functionalization. The results suggested that the cytotoxicity of carbon dots was dependent on the selection of surface passivation molecules. Those dots showing more significant cytotoxicity at higher concentrations were also evaluated for their effects on the fluorescence imaging of live cells. The implications of the results on the eventual use of carbon dots as cell imaging agents are discussed.

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A facile, green synthesis of highly fluorescent carbon nanoparticles from oatmeal for cell imaging

Journal of Materials Chemistry C ◽

10.1039/c5tc02057c ◽

2015 ◽

Vol 3 (37) ◽

pp. 9514-9518 ◽

Cited By ~ 26

Author(s):

Caiyan Yu ◽

Tongtong Xuan ◽

Yiwei Chen ◽

Zhenjie Zhao ◽

Zhuo Sun ◽

...

Keyword(s):

Green Synthesis ◽

Hydrothermal Treatment ◽

Carbon Nanoparticles ◽

Cell Imaging ◽

Bio Imaging ◽

Fluorescent Carbon Nanoparticles ◽

Fluorescent Carbon

Highly luminescent CNPs with a PLQY of 37.40% were first synthesized via a simple hydrothermal treatment of green oatmeal for bio-imaging.

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Using pH-Activable Carbon Nanoparticles as Cell Imaging Probes

Micromachines ◽

10.3390/mi10090568 ◽

2019 ◽

Vol 10 (9) ◽

pp. 568 ◽

Cited By ~ 1

Author(s):

Honggui Lin ◽

Jianlong Su ◽

Ranjith Kumar Kankala ◽

Mingrong Zeng ◽

Shu-Feng Zhou ◽

...

Keyword(s):

Carbon Nanoparticles ◽

Cell Imaging ◽

Photoluminescence Properties ◽

Tumor Cell Death ◽

Ph Change ◽

Ph Values ◽

Imaging Probes ◽

Internalization Process ◽

Biological Labeling ◽

Dependent Modification

Herein, we demonstrate the fabrication of innovative pH-activable carbon nanoparticles (CNPs) based on urea and citric acid by microwave-assisted green synthesis for application in cell imaging. These CNP-based nanoprobes offer significant advantages of pH responsiveness and excellent biocompatibility. The pH responsiveness ranges from 1.0 to 4.6 and the slightly pH responsiveness ranges from 4.6 to 9.0. In addition, the pH-dependent modification of charge as well as the final diameter of the designed CNPs not only provide support as stable sensors for cell imaging under pH values from 4.6 to 9.0, but can also observe the pH change in cells from 1.0 to 4.6. Importantly, this significantly enhances the cellular internalization process resulting in tumor cell death. Together, we believe that these superior photoluminescence properties of our designed nanomaterials potentially allow for biological labeling, bioimaging, and drug delivery applications.

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Monosodium glutamate derived tricolor fluorescent carbon nanoparticles for cell-imaging application

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2016.02.037 ◽

2016 ◽

Vol 142 ◽

pp. 123-129 ◽

Cited By ~ 4

Author(s):

Nannan Zheng ◽

Sha Ding ◽

Xingping Zhou

Keyword(s):

Carbon Nanoparticles ◽

Cell Imaging ◽

Monosodium Glutamate ◽

Imaging Application ◽

Fluorescent Carbon Nanoparticles ◽

Fluorescent Carbon

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Multicolour fluorescent carbon nanoparticle probes for live cell imaging and dual palladium and mercury sensors

Journal of Materials Chemistry B ◽

10.1039/c6tb00238b ◽

2016 ◽

Vol 4 (14) ◽

pp. 2466-2476 ◽

Cited By ~ 64

Author(s):

Vinay Sharma ◽

Anoop Kumar Saini ◽

Shaikh M. Mobin

Keyword(s):

Quantum Yield ◽

Carbon Nanoparticles ◽

Live Cell Imaging ◽

Cell Imaging ◽

High Quantum Yield ◽

Carbon Nanoparticle ◽

Nanoparticle Probes ◽

High Quantum ◽

Dual Sensor ◽

Mercury Sensors

Cytocompatible carbon nanoparticles (CNPs) having high quantum yield and multicolour bioimaging properties were synthesized and employed as sensitive, selective and rapid dual sensor for Pd2+ and Hg2+.

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