An unprecedented oxidative intermolecular homo coupling reaction between two sp3C–sp3C centers under metal-free condition

2016 ◽  
Vol 57 (31) ◽  
pp. 3476-3480 ◽  
Author(s):  
Santosh K. Sahoo
Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2225 ◽  
Author(s):  
Yongjun Bian ◽  
Xingyu Qu ◽  
Yongqiang Chen ◽  
Jun Li ◽  
Leng Liu

Thiourea as a sulfur atom transfer reagent was applied for the synthesis of aryl thioamides through a three-component coupling reaction with aryl aldehydes and N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMAC). The reaction could tolerate various functional groups and gave moderate to good yields of desired products under the transition-metal-free condition.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Peng-Ying Jiang ◽  
Kai-Fang Fan ◽  
Shaoyu Li ◽  
Shao-Hua Xiang ◽  
Bin Tan

AbstractAs an important platform molecule, atropisomeric QUINOL plays a crucial role in the development of chiral ligands and catalysts in asymmetric catalysis. However, efficient approaches towards QUINOL remain scarce, and the resulting high production costs greatly impede the related academic research as well as downstream industrial applications. Here we report a direct oxidative cross-coupling reaction between isoquinolines and 2-naphthols, providing a straightforward and scalable route to acquire the privileged QUINOL scaffolds in a metal-free manner. Moreover, a NHC-catalyzed kinetic resolution of QUINOL N-oxides with high selectivity factor is established to access two types of promising axially chiral Lewis base catalysts in optically pure forms. The utility of this methodology is further illustrated by facile transformations of the products into QUINAP, an iconic ligand in asymmetric catalysis.


Author(s):  
Wei Zhang ◽  
Shiqun Xiang ◽  
Weibin Fan ◽  
Jiang Jin ◽  
Yinghua Li ◽  
...  

A metal-free synthesis of heterodifunctional indole derivaties is developed through TBHP/KI-mediated oxidative coupling. The reaction constructs C-O and C-C bonds in succession with the help of tert-butyl peroxy radicals generated...


2020 ◽  
Vol 22 (14) ◽  
pp. 4550-4560
Author(s):  
Wenjuan Fang ◽  
Zhencai Zhang ◽  
Zifeng Yang ◽  
Yaqin Zhang ◽  
Fei Xu ◽  
...  

A synthetic strategy for bio-based polycarbonate was developed via one-pot polymerization of renewable monomer isosorbide and dimethyl carbonate using eco-friendly organo-catalysts.


2018 ◽  
Vol 16 (33) ◽  
pp. 6017-6024 ◽  
Author(s):  
Bin Sun ◽  
Shi Yin ◽  
Xiaohui Zhuang ◽  
Can Jin ◽  
Weike Su

We developed a novel metal-free method for the construction of C(sp2)–O bonds via oxidative cross-coupling reactions between various N-substituted anilines and hydroxylamine derivatives just using commercially available Selectfluor as an oxidant.


2020 ◽  
Vol 65 (10) ◽  
pp. 61-66
Author(s):  
Trang Nguyen Thi Minh ◽  
Trang Tran Thi Thu ◽  
Hoan Duong Quoc

Salicylic aldehydes, amine, and phenyl acetylene could react under the solvent-free, metal-free conditions to form propargylamines 1-4 via A3 coupling reaction. The yield of the reaction was up to 83% for 5h. In acetonitrile, the amine became a catalyst to form 6-bromo-3-(5-bromo-2-hydroxybenzyl)-2-phenyl-4Hchromen-4-one (5). Under microwave conditions, it took about 20 min to complete the reaction and gave the same yields as theconventional method. Structures of these compounds were firm with NMR, MS spectra.


ChemInform ◽  
2012 ◽  
Vol 43 (33) ◽  
pp. no-no
Author(s):  
Mitsuhiro Ueda ◽  
Kota Nishimura ◽  
Ryo Kashima ◽  
Ilhyong Ryu

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