Enablers of continuous processing of biotherapeutic products

2022 ◽  
Author(s):  
Anurag S. Rathore ◽  
Andrew L. Zydney ◽  
Anupa Anupa ◽  
Saxena Nikita ◽  
Neelesh Gangwar
Keyword(s):  
Continuous Processing

A machine for real-time estimation of the tribological characteristics of materials

2020 ◽  
Vol 86 (4) ◽  
pp. 61-65
Author(s):  
M. V. Abramchuk ◽  
R. V. Pechenko ◽  
K. A. Nuzhdin ◽  
V. M. Musalimov
Keyword(s):  
Real Time ◽  
Time Estimation ◽  
Tribological Characteristics ◽  
Continuous Processing ◽  
Friction Machine ◽  
Dynamic Friction Coefficient ◽  
Displacement Sensors ◽  
Frictional Interaction ◽  
Real Time Estimation ◽  
Automated Quality Control

A reciprocating friction machine Tribal-T intended for automated quality control of the rubbing surfaces of tribopairs is described. The distinctive feature of the machine consists in implementation of the forced relative motion due to the frictional interaction of the rubbing surfaces fixed on the drive and conjugate platforms. Continuous processing of the signals from displacement sensors is carried out under conditions of continuous recording of mutual displacements of loaded tribopairs using classical approaches of the theory of automatic control to identify the tribological characteristics. The machine provides consistent visual real time monitoring of the parameters. The MATLAB based computer technologies are actively used in data processing. The calculated tribological characteristics of materials, i.e., the dynamic friction coefficient, damping coefficient and measure of the surface roughness, are presented. The tests revealed that a Tribal-T reciprocating friction machine is effective for real-time study of the aforementioned tribological characteristics of materials and can be used for monitoring of the condition of tribo-nodes of machines and mechanisms.

scholarly journals New frontiers in enzyme immobilisation: robust biocatalysts for a circular bio-based economy

2021 ◽  
Author(s):  
Roger A. Sheldon ◽  
Alessandra Basso ◽  
Dean Brady
Keyword(s):  
Cost Effective ◽  
Continuous Processing ◽  
Enzyme Immobilisation ◽  
Recent Advances ◽  
Effective Use

This tutorial review focuses on recent advances in technologies for enzyme immobilisation, enabling their cost-effective use in the bio-based economy and continuous processing in general.

scholarly journals Selective Separation of Amines from Continuous Processes using Automated pH Controlled Extraction

2021 ◽  
Author(s):  
Luke Power ◽  
Adam D. Clayton ◽  
William Reynolds ◽  
David Hose ◽  
Caroline Ainsworth ◽  
...  
Keyword(s):  
Liquid Extraction ◽  
Selective Separation ◽  
Continuous Processing ◽  
Online Analysis ◽  
Continuous Processes ◽  
Liquid Liquid Extraction ◽  
Ph Controlled

We present a rapid continuous processing methodology to screen for the optimal, selective, liquid-liquid extraction conditions, from a typical post-reaction mixture of amines, using both inline and online analysis to...

scholarly journals Concentric annular liquid–liquid phase separation for flow chemistry and continuous processing

2021 ◽  
Author(s):  
Matthew J. Harding ◽  
Bin Feng ◽  
Rafael Lopez-Rodriguez ◽  
Heather O'Connor ◽  
Denis Dowling ◽  
...  
Keyword(s):  
Phase Separation ◽  
Liquid Phase ◽  
Low Cost ◽  
Flow Chemistry ◽  
Continuous Processing ◽  
Surface Wetting ◽  
Tubular Membrane ◽  
Annular Channels ◽  
Phase Separator ◽  
Liquid Liquid Phase Separation

A low-cost, modular, robust, and easily customisable continuous liquid–liquid phase separator has been developed that uses a tubular membrane and annular channels to allow high fluidic throughputs while maintaining rapid, surface wetting dominated, phase separation.

Study on the Green Nitration of Toluene in a Microglass Reactor

2011 ◽  
Vol 396-398 ◽  
pp. 2018-2022
Author(s):  
Bin Dong Li ◽  
Jian Wu ◽  
Xiao Ming Ma
Keyword(s):  
Ionic Liquids ◽  
Nitric Acid ◽  
Continuous Processing ◽  
Efficient Process ◽  
Controlled Conditions ◽  
Recyclable Catalysts

Continuous processing in the microreactor represents a novel way for the safe and expedient conduct of high energetic nitration. Apart from handling benefits,nitration in microreactors proceed under precisely controlled conditions providing improved yields and selectivity. This paper studied the nitration of toluene in the microglass reactor using concentrated nitric acid as the nitrating agent and SO3H-functional ionic liquids, Lanthanide(iii) trifluoroacetate as recyclable catalysts. We described a mild, efficient process for the nitration of toluene.

Continuous Processing of Sheet-Like Materials by Microwave Energy

1996 ◽  
Vol 430 ◽  
Author(s):  
David A. Lewis ◽  
Stanley J. Whitehair ◽  
Alfred Viehbeck ◽  
Jane M. Shaw
Keyword(s):  
Microwave Processing ◽  
Microwave Energy ◽  
Circuit Board ◽  
Process Window ◽  
Glass Cloth ◽  
Continuous Processing ◽  
Microwave Applicator ◽  
Initial Results

AbstractInitial results for the continuous microwave processing of wide webs using a new microwave applicator are presented. The results show that acceptable uniformity can be obtained using this system and that with the appropriate controls, a very tight process window can be maintained to produce preimpregnated glass cloth (prepreg) for use in circuit board manufacture.

Challenges in process control for continuous processing for production of monoclonal antibody products

2021 ◽  
Vol 31 ◽  
pp. 100671
Author(s):  
Anurag S Rathore ◽  
Saxena Nikita ◽  
Garima Thakur ◽  
Navnath Deore
Keyword(s):  
Monoclonal Antibody ◽  
Process Control ◽  
Continuous Processing
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