The possible protective effect of simvastatin and pioglitazone separately and in combination on bleomycin-induced changes in mice thin skin

2015 ◽  
Vol 47 (2) ◽  
pp. 159-170 ◽  
Author(s):  
Samah Kandeel ◽  
Mohamed Balaha
Keyword(s):  
Protective Effect ◽  
Thin Skin ◽  
Induced Changes

Protective effect of esterified glucomannan on aflatoxin-induced changes in testicular function, sperm quality, and seminal plasma biochemistry in rams

2014 ◽  
Vol 81 (3) ◽  
pp. 373-380 ◽  
Author(s):  
Mehmet Bozkurt Ataman ◽  
Hasan Hüseyin Dönmez ◽  
Nurcan Dönmez ◽  
Emrah Sur ◽  
Mustafa Numan Bucak ◽  
...  
Keyword(s):  
Protective Effect ◽  
Seminal Plasma ◽  
Sperm Quality ◽  
Testicular Function ◽  
Plasma Biochemistry ◽  
Induced Changes

Protective Effect of Hemidesmus indicus L. R. Br. Against Bromobenzene-Induced Mitochondrial Dysfunction in Rat Kidney

2012 ◽  
Vol 40 (03) ◽  
pp. 567-580 ◽  
Author(s):  
Vadde Ramakrishna ◽  
Sriram Gopi ◽  
Oruganti H. Setty
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Mitochondrial Dysfunction ◽  
Rat Kidney ◽  
Radical Scavenging ◽  
Histopathological Changes ◽  
Traditional Herbal Medicine ◽  
Hemidesmus Indicus ◽  
Induced Changes ◽  
Prior Administration

Hemidesmus indicus (HI) is used in ancient Indian traditional herbal medicine to treat hepatic and renal disorders. The present study was designed to investigate the protective effect of HI aqueous extract against bromobenzene induced mitochondrial dysfunction in rat kidneys. Rats were administered bromobenzene with or without prior administration of HI or vitamin E. At the end of the experiment animals were sacrificed and kidneys were obtained to study mitochondrial function, oxidative stress parameters and histopathology. Administration of bromobenzene caused significant changes like: decrease in the mitochondrial respiration and P/O ratios, increase in lipid peroxidation and protein oxidation, and decrease in the activities of antioxidant enzymes (catalase, glutathione reductase, glutathione peroxidase and superoxide dismutase) in mitochondria with significant histopathological changes in the kidney. Prior administration of HI extract showed a significant protection against bromobenzene induced changes in the kidney and this effect is attributed to the antioxidant and free radical scavenging potential of the HI. The protection was much better with HI compared to vitamin E.

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