Protective Effect of Hemidesmus indicus L. R. Br. Against Bromobenzene-Induced Mitochondrial Dysfunction in Rat Kidney

2012 ◽  
Vol 40 (03) ◽  
pp. 567-580 ◽  
Author(s):  
Vadde Ramakrishna ◽  
Sriram Gopi ◽  
Oruganti H. Setty
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Mitochondrial Dysfunction ◽  
Rat Kidney ◽  
Radical Scavenging ◽  
Histopathological Changes ◽  
Traditional Herbal Medicine ◽  
Hemidesmus Indicus ◽  
Induced Changes ◽  
Prior Administration

Hemidesmus indicus (HI) is used in ancient Indian traditional herbal medicine to treat hepatic and renal disorders. The present study was designed to investigate the protective effect of HI aqueous extract against bromobenzene induced mitochondrial dysfunction in rat kidneys. Rats were administered bromobenzene with or without prior administration of HI or vitamin E. At the end of the experiment animals were sacrificed and kidneys were obtained to study mitochondrial function, oxidative stress parameters and histopathology. Administration of bromobenzene caused significant changes like: decrease in the mitochondrial respiration and P/O ratios, increase in lipid peroxidation and protein oxidation, and decrease in the activities of antioxidant enzymes (catalase, glutathione reductase, glutathione peroxidase and superoxide dismutase) in mitochondria with significant histopathological changes in the kidney. Prior administration of HI extract showed a significant protection against bromobenzene induced changes in the kidney and this effect is attributed to the antioxidant and free radical scavenging potential of the HI. The protection was much better with HI compared to vitamin E.

scholarly journals Protective Effect of Houttuynia cordata Extract on Bleomycin-Induced Pulmonary Fibrosis in Rats

2007 ◽  
Vol 35 (03) ◽  
pp. 465-475 ◽  
Author(s):  
Lean-Teik Ng ◽  
Feng-Lin Yen ◽  
Chia-Wen Liao ◽  
Chun-Ching Lin
Keyword(s):  
Vitamin E ◽  
Pulmonary Fibrosis ◽  
Protective Effect ◽  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Liver Homogenate ◽  
Lavage Fluid ◽  
Model Systems ◽  
Houttuynia Cordata

The present study aimed to examine the antioxidant properties of Houttuynia cordata (HC) and its protective effect on bleomycin-induced pulmonary fibrosis in rats. Results showed that aqueous extract of HC exhibited a different magnitude of antioxidant activities in all model systems tested. Although HC showed weaker free radical scavenging and xanthine oxidase inhibitory activity than vitamin E, its anti-lipid peroxidation activity in rat liver homogenate was close to that of vitamin E. In animal studies, HC significantly decreased the levels of superoxide dismutase, malondialdehyde, hydroxyproline, interferon-γ, and tumor necrosis factor-α. However, an increase in the concentration of catalase was noted in the bronchoalveolar lavage fluid. HC also remarkably improved the morphological appearance of the lung of bleomycin-treated rats. These results suggest that HC possesses a protective effect against bleomycin-induced pulmonary fibrosis. Interestingly, this protective effect was more pronounced than that of vitamin E. In conclusion, the protective effect of HC on pulmonary fibrosis could be partly associated with the reduction of oxidative damage caused by bleomycin.

scholarly journals Protective effect of gallic acid and gallic acid-loaded Eudragit-RS 100 nanoparticles on cisplatin-induced mitochondrial dysfunction and inflammation in rat kidney

2020 ◽  
Vol 1866 (12) ◽  
pp. 165911 ◽  
Author(s):  
Mohammad Amin Dehghani ◽  
Nader Shakiba Maram ◽  
Eskandar Moghimipour ◽  
Layasadat Khorsandi ◽  
Morteza Atefi khah ◽  
...  
Keyword(s):  
Protective Effect ◽  
Mitochondrial Dysfunction ◽  
Gallic Acid ◽  
Rat Kidney ◽  
Eudragit Rs

Protective Effect of Vitamin E on Formaldehyde-Induced Injuries in the Rat Kidney

2014 ◽  
Vol 1 (3) ◽  
Author(s):  
Masoumeh Faghani ◽  
Yeganezahra Kohestani ◽  
Ebrahim Nasiri ◽  
Hassan Moladoust ◽  
Mojgan Mesbah
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Rat Kidney

Beneficial effect of the bioflavonoid quercetin on cholecystokinin-induced mitochondrial dysfunction in isolated rat pancreatic acinar cells

2014 ◽  
Vol 92 (3) ◽  
pp. 215-225 ◽  
Author(s):  
Heike Weber ◽  
Ludwig Jonas ◽  
Michael Wakileh ◽  
Burkhard Krüger
Keyword(s):  
Protective Effect ◽  
Mitochondrial Dysfunction ◽  
Dehydrogenase Activity ◽  
Mitochondrial Membrane ◽  
Acinar Cells ◽  
Pharmacological Therapy ◽  
Pancreatic Acinar Cells ◽  
Inner Mitochondrial Membrane ◽  
Atp Supply ◽  
Induced Changes

The pathogenesis of acute pancreatitis (AP) is still poorly understood. Thus, a reliable pharmacological therapy is currently lacking. In recent years, an impairment of the energy metabolism of pancreatic acinar cells, caused by Ca2+-mediated depolarization of the inner mitochondrial membrane and a decreased ATP supply, has been implicated as an important pathological event. In this study, we investigated whether quercetin exerts protection against mitochondrial dysfunction. Following treatment with or without quercetin, rat pancreatic acinar cells were stimulated with supramaximal cholecystokinin-8 (CCK). CCK caused a decrease in the mitochondrial membrane potential (MMP) and ATP concentration, whereas the mitochondrial dehydrogenase activity was significantly increased. Quercetin treatment before CCK application exerted no protection on MMP but increased ATP to a normal level, leading to a continuous decrease in the dehydrogenase activity. The protective effect of quercetin on mitochondrial function was accompanied by a reduction in CCK-induced changes to the cell membrane. Concerning the molecular mechanism underlying the protective effect of quercetin, an increased AMP/ATP ratio suggests that the AMP-activated protein kinase system may be activated. In addition, quercetin strongly inhibited CCK-induced trypsin activity. The results indicate that the use of quercetin may be a therapeutic strategy for reducing the severity of AP.

Protective Effect of Vitamin E on Immune Triggered, Granulocyte Mediated Endothelial Injury

1984 ◽  
Vol 51 (01) ◽  
pp. 089-092 ◽  
Author(s):  
M A Boogaerts ◽  
J Van de Broeck ◽  
H Deckmyn ◽  
C Roelant ◽  
J Vermylen ◽  
...  
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Umbilical Vein ◽  
Endothelial Damage ◽  
Endothelial Injury ◽  
Mediated Effects ◽  
Anti Oxidant ◽  
Endothelial Cell Cultures ◽  
Vitro Model

SummaryThe effect of alfa-tocopherol on the cell-cell interactions at the vessel wall were studied, using an in vitro model of human umbilical vein endothelial cell cultures (HUEC). Immune triggered granulocytes (PMN) will adhere to and damage HUEC and platelets enhance this PMN mediated endothelial injury. When HUEC are cultured in the presence of vitamin E, 51Cr-leakage induced by complement stimulated PMN is significantly decreased and the enhanced cytotoxicity by platelets is completely abolished (p <0.001).The inhibition of PMN induced endothelial injury is directly correlated to a diminished adherence of PMN to vitamin E- cultured HUEC (p <0.001), which may be mediated by an increase of both basal and stimulated endogenous prostacyclin (PGI2) from alfa-tocopherol-treated HUEC (p <0.025). The vitamin E-effect is abolished by incubation of HUEC with the irreversible cyclo-oxygenase inhibitor, acetylsalicylic acid, but the addition of exogenous PGI2 could not reproduce the vitamin E-mediated effects.We conclude that vitamin E exerts a protective effect on immune triggered endothelial damage, partly by increasing the endogenous anti-oxidant potential, partly by modulating intrinsic endothelial prostaglandin production. The failure to reproduce vitamin E-protection by exogenously added PGI2 may suggest additional, not yet elucidated vitamin E-effects on endothelial metabolism.

Seizure-induced changes in energy metabolites and effects of N-tert-butyl-α-phenylnitrone (PNB) and vitamin E in rats

2000 ◽  
Vol 440 (S1) ◽  
pp. R160-R162 ◽  
Author(s):  
Ramesh C. Gupta ◽  
Dejan Milatovic ◽  
Marko Zivin ◽  
Wolf-D. Dettbarn
Keyword(s):  
Vitamin E ◽  
Energy Metabolites ◽  
Tert Butyl ◽  
Induced Changes

Protective effect of vitamin E on lymphocyte growth capacity during incubation in vitro

1995 ◽  
Vol 82 (2-3) ◽  
pp. 129-148 ◽  
Author(s):  
Ke-Yin Tu ◽  
Randall Matthews ◽  
Kathleen S. Matthews
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Growth Capacity ◽  
Lymphocyte Growth
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