Inside-out and outside-in organotypic normal human skin culture: JAK-STAT pathway is activated after pro-inflammatory psoriatic cytokine exposure

2021 ◽  
pp. 101675
Author(s):  
L. Cornaghi ◽  
N. Gagliano ◽  
F.W. Baruffaldi Preis ◽  
F. Prignano ◽  
E. Donetti
Keyword(s):  
Human Skin ◽  
Normal Human Skin ◽  
Skin Culture ◽  
Normal Human ◽  
Inside Out ◽  
Stat Pathway

The Effect of Practolol, In Vitro Generated Metabolites of Practolol and Chemical Analogues on the Rate of Growth of Human Skin Fibroblasts

1984 ◽  
Vol 12 (2) ◽  
pp. 89-97
Author(s):  
Graham R. Elliott ◽  
H.E. Amos ◽  
James W. Bridges
Keyword(s):  
Human Skin ◽  
Psoriasis Patient ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Cell Type ◽  
Normal Human Skin ◽  
Rate Of Growth ◽  
Structural Analogues ◽  
Normal Human

The rate of growth of normal human skin fibroblasts was inhibited in a dose related, reversible, fashion by practolol (N-4-(2-hydroxy)-3 (1-methyl)-aminopropoxyphenylacetamine) (ID50 1.35 ± 0.14 x 10-3M), propranolol (1-(isopropylamino)-3(1-naphthyl-oxy)-2-propranolol) (ID50 0.145 ± 0.02 x 10-3M) and paracetamol (N-(4-hydroxyphenyl) acetamide) (ID50 0.85 ± 0.2 x 10-3M). Skin fibroblasts isolated from a psoriasis patient were more sensitive towards practolol (ID50 0.48 ± 0.14 x 10-3M) and propranolol (ID50 0.032 ± 0.002 x 10-3M), but less sensitive towards paracetamol (ID50 1.3 ± 0.07 x 10-3M). In vitro generated metabolites of practolol, using normal or Arochlor 1254-pretreated hamster liver preparations, and structural analogues of practolol had no effect upon the growth of either cell type.

Type I and III collagen content and fibre distribution in normal human skin during ageing

1987 ◽  
Vol 117 (4) ◽  
pp. 419-428 ◽  
Author(s):  
C.R. LOVELL ◽  
K.A. SMOLENSKI ◽  
V.C. DUANCE ◽  
N.D. LIGHT ◽  
S. YOUNG ◽  
...  
Keyword(s):  
Human Skin ◽  
Collagen Content ◽  
Type I ◽  
Normal Human Skin ◽  
Fibre Distribution ◽  
Normal Human

scholarly journals C3b Receptor in Normal Human Skin

1981 ◽  
Vol 77 (4) ◽  
pp. 353-357 ◽  
Author(s):  
Hakan N. Thyresson ◽  
Frederic C. McDuffie ◽  
Arnold L. Schroeter
Keyword(s):  
Human Skin ◽  
Normal Human Skin ◽  
C3b Receptor ◽  
Normal Human

Expression of Transferrin Receptor in Normal Human Skin, Psoriatic Skin and Various Skin Tumors

1988 ◽  
Vol 15 (3) ◽  
pp. 208-211 ◽  
Author(s):  
Mitsuru Iwata ◽  
Fujio Otsuka ◽  
Shin-ichi Watanabe ◽  
Tatsutoshi Nogita ◽  
Yasumasa Ishibashi
Keyword(s):  
Human Skin ◽  
Transferrin Receptor ◽  
Skin Tumors ◽  
Psoriatic Skin ◽  
Normal Human Skin ◽  
Normal Human
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