scholarly journals Modular analysis of the transcriptional regulatory network of E. coli

2005 ◽  
Vol 21 (1) ◽  
pp. 16-20 ◽  
Author(s):  
Osbaldo Resendis-Antonio ◽  
Julio A. Freyre-González ◽  
Ricardo Menchaca-Méndez ◽  
Rosa M. Gutiérrez-Ríos ◽  
Agustino Martínez-Antonio ◽  
...  
Keyword(s):  
Regulatory Network ◽  
Transcriptional Regulatory Network ◽  
E Coli ◽  
Transcriptional Regulatory ◽  
Modular Analysis

scholarly journals Antibiotic tolerance is associated with a broad and complex transcriptional response in E. coli

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Heather S. Deter ◽  
Tahmina Hossain ◽  
Nicholas C. Butzin
Keyword(s):  
Transcriptional Regulatory Network ◽  
Transcriptional Response ◽  
Regulatory Proteins ◽  
Health Concern ◽  
Transcriptional Networks ◽  
Antibiotic Tolerance ◽  
Multiple Gene ◽  
E Coli ◽  
Transcriptional Regulatory ◽  
Antibiotic Efficacy

AbstractAntibiotic treatment kills a large portion of a population, while a small, tolerant subpopulation survives. Tolerant bacteria disrupt antibiotic efficacy and increase the likelihood that a population gains antibiotic resistance, a growing health concern. We examined how E. coli transcriptional networks changed in response to lethal ampicillin concentrations. We are the first to apply transcriptional regulatory network (TRN) analysis to antibiotic tolerance by leveraging existing knowledge and our transcriptional data. TRN analysis shows that gene expression changes specific to ampicillin treatment are likely caused by specific sigma and transcription factors typically regulated by proteolysis. These results demonstrate that to survive lethal concentration of ampicillin specific regulatory proteins change activity and cause a coordinated transcriptional response that leverages multiple gene systems.

scholarly journals Topological and causal structure of the yeast transcriptional regulatory network

10.1038/ng873 ◽  
2002 ◽  
Vol 31 (1) ◽  
pp. 60-63 ◽  
Author(s):  
Nabil Guelzim ◽  
Samuele Bottani ◽  
Paul Bourgine ◽  
François Képès
Keyword(s):  
Regulatory Network ◽  
Transcriptional Regulatory Network ◽  
Causal Structure ◽  
Transcriptional Regulatory
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