Cadmium induces apoptosis via generating reactive oxygen species to activate mitochondrial p53 pathway in primary rat osteoblasts

Toxicology ◽  
2020 ◽  
Vol 446 ◽  
pp. 152611
Author(s):  
Jiaming Zheng ◽  
Liling Zhuo ◽  
Di Ran ◽  
Yonggang Ma ◽  
Tongwang Luo ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
P53 Pathway ◽  
Rat Osteoblasts

IGF-I enhances cellular senescence via the reactive oxygen species–p53 pathway

2012 ◽  
Vol 425 (2) ◽  
pp. 478-484 ◽  
Author(s):  
Anastasia-Evi Handayaningsih ◽  
Michiko Takahashi ◽  
Hidenori Fukuoka ◽  
Genzo Iguchi ◽  
Hitoshi Nishizawa ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cellular Senescence ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
P53 Pathway ◽  
Igf I

Linalool Suppresses Proliferation and Promotes Apoptosis in Gastric Cancer Cells via Activation of Reactive Oxygen Species-Mediated P53 Pathway

2020 ◽  
Vol 18 (4) ◽  
pp. 325-330
Author(s):  
Haitao Ding ◽  
Zhijun Han ◽  
Jie Cao ◽  
Xiuli Yang
Keyword(s):  
Gastric Cancer ◽  
Reactive Oxygen Species ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Gastric Cancer Cells ◽  
P53 Pathway ◽  
Dose Dependent Fashion ◽  
Markers Of Oxidative Stress ◽  
Cancer Agent

The role of linalool in gastric cancer has been examined by measuring its effects on cell cytotoxicity, apoptosis, and accumulation of reactive oxygen species as well as markers of oxidative stress. In a dose-dependent fashion, linalool suppressed the viability of gastric cancer cells and increased accumulation of reactive oxygen species with a concomitant increase in malondialdehyde, cleavage of caspase 3 and p53 and decrease in superoxide dismutase and glutathione peroxidase. N-acetyl cysteine, a scavenger of reactive oxygen species reduced the effects of linalool on gastric cancer cells. In conclusion, linalool suppresses cell viability and promotes cell apoptosis of gastric cancer cells via activation of reactive oxygen species-mediated p53 pathway suggesting that linalool might serve as a potential anti-cancer agent.

scholarly journals Juglone potentiates BRAF inhibitor‑induced apoptosis in melanoma through reactive oxygen species and the p38‑p53 pathway

2020 ◽  
Vol 22 (1) ◽  
pp. 566-574
Author(s):  
Zheng Li ◽  
Xiao Liu ◽  
Ming Li ◽  
Jingxiu Chai ◽  
Shan He ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Braf Inhibitor ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
P53 Pathway ◽  
Induced Apoptosis

Mitochondria as a source of reactive oxygen species

2009 ◽  
pp. c3 ◽  
Author(s):  
Helena M. Cochemé ◽  
Michael P. Murphy
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species
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