A toxicogenomics approach for risk assessment of glutathione depletion and oxidative stress-induced nongenotoxic hepatocarcinogenesis in the rat liver

2006 ◽  
Vol 164 ◽  
pp. S5-S6
Author(s):  
Takeki Uehara ◽  
Naoki Kiyosawa ◽  
Atsushi Ono ◽  
Toshikazu Miyagishima ◽  
Tetsuro Urushidani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Assessment ◽  
Rat Liver ◽  
Glutathione Depletion ◽  
And Oxidative Stress

Ethacrynic-acid-induced glutathione depletion and oxidative stress in normal and Mrp2-deficient rat liver

2004 ◽  
Vol 37 (11) ◽  
pp. 1718-1729 ◽  
Author(s):  
Bin Ji ◽  
Kousei Ito ◽  
Shuichi Sekine ◽  
Ai Tajima ◽  
Toshiharu Horie
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
Ethacrynic Acid ◽  
Glutathione Depletion ◽  
And Oxidative Stress

Possible Effects of Lycopene and Silymarin on Rat Liver Functions and Oxidative Stress Markers

2014 ◽  
Vol 39 (3) ◽  
pp. 344-350 ◽  
Author(s):  
Aysun Kilic Suloglu, PhD ◽  
Assoc. Prof. Gozde Girgin, PhD ◽  
Prof. Guldeniz Selmanoglu, PhD ◽  
Serdar Balci, MD ◽  
Prof. Terken Baydar, PhD
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Liver Functions ◽  
And Oxidative Stress

scholarly journals The severity of rat liver injury by fructose and high fat depends on the degree of respiratory dysfunction and oxidative stress induced in mitochondria

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Claudia Isabel García-Berumen ◽  
Omar Ortiz-Avila ◽  
Manuel Alejandro Vargas-Vargas ◽  
Bricia A. del Rosario-Tamayo ◽  
Clotilde Guajardo-López ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Rat Liver ◽  
High Fat ◽  
Respiratory Dysfunction ◽  
And Oxidative Stress

Quercetin protects rat hepatocytes from oxidative damage induced by ethanol and iron by maintaining intercellular liable iron pool

2013 ◽  
Vol 33 (5) ◽  
pp. 534-541 ◽  
Author(s):  
Y Li ◽  
Y Deng ◽  
Y Tang ◽  
H Yu ◽  
C Gao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Iron Overload ◽  
Combined Treatment ◽  
Rat Hepatocytes ◽  
Redox Status ◽  
Glutathione Depletion ◽  
Labile Iron Pool ◽  
Iron Pool ◽  
And Oxidative Stress

Accumulating evidence has shown that ethanol-induced iron overload plays a crucial role in the development and progression of alcoholic liver disease. We designed the present study to investigate the potential protective effect of quercetin, a naturally occurring iron-chelating antioxidant on alcoholic iron overload and oxidative stress. Ethanol-incubated (100 mmol/L) rat primary hepatocytes were co-treated by quercetin (100 µmol/L) and different dose of ferric nitrilotriacetate (Fe-NTA) for 24 h. When the hepatic enzyme releases in the culture medium, redox status of hepatocytes and the intercellular labile iron pool (LIP) level were assayed. Our data showed that Fe-NTA dose dependently induced cellular leakage of aspartate transaminase and lactate dehydrogenase, glutathione depletion, superoxide dismutase inactivation, and overproduction of malondialdehyde) and reactive oxygen species (ROS) of intact and especially ethanol-incubated hepatocytes. The oxidative damage resulted from ethanol, Fe-NTA, and especially their combined treatment was substantially alleviated by quercetin, accompanying the corresponding normalization of intercellular LIP level. Iron in excess, thus, may aggravate ethanol hepatotoxicity through Fenton-active LIP, and quercetin attenuated ethanol-induced iron and oxidative stress. To maintain intercellular LIP contributes to the hepatoprotective effect of quercetin besides its direct ROS-quenching activity.

ABT-737, a BH3 mimetic, induces glutathione depletion and oxidative stress

2009 ◽  
Vol 65 (1) ◽  
pp. 41-54 ◽  
Author(s):  
Adrienne N. Howard ◽  
Kathleen A. Bridges ◽  
Raymond E. Meyn ◽  
Joya Chandra
Keyword(s):  
Oxidative Stress ◽  
Glutathione Depletion ◽  
And Oxidative Stress ◽  
Bh3 Mimetic

Significance of glutathione depletion and oxidative stress in early embryogenesis in glucose-induced rat embryo culture

Diabetes ◽  
1995 ◽  
Vol 44 (8) ◽  
pp. 992-998 ◽  
Author(s):  
R. A. Trocino ◽  
S. Akazawa ◽  
M. Ishibashi ◽  
K. Matsumoto ◽  
H. Matsuo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Embryo Culture ◽  
Early Embryogenesis ◽  
Glutathione Depletion ◽  
Rat Embryo ◽  
Rat Embryo Culture ◽  
And Oxidative Stress
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