Red palm oil reverses lead-induced lipid dysfunction and biochemical alterations in the plasma of Wistar rats

The possible protective effects of an aqueous rooibos extract (Aspalathus linearis), red palm oil (RPO) (Elaeis guineensis), or their combination ontert-butyl-hydroperoxide-(t-BHP-)induced oxidative hepatotoxicity in Wistar rats were investigated.tert-butyl hydroperoxide caused a significant (P<0.05) elevation in conjugated dienes (CD) and malondialdehyde (MDA) levels, significantly (P<0.05) decreased reduced glutathione (GSH) and GSH : GSSG ratio, and induced varying changes in activities of catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase in the blood and liver. This apparent oxidative injury was associated with histopathological changes in liver architecture and elevated levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH). Supplementation with rooibos, RPO, or their combination significantly (P<0.05) decreased CD and MDA levels in the liver and reduced serum level of ALT, AST, and LDH. Likewise, changes observed in the activities of antioxidant enzymes and impairment in redox status in the erythrocytes and liver were reversed. The observed protective effects when rooibos and RPO were supplemented concomitantly were neither additive nor synergistic. Our results suggested that rooibos and RPO, either supplemented alone or combined, are capable of alleviatingt-BHP-induced oxidative hepatotoxicity, and the mechanism of this protection may involve inhibition of lipid peroxidation and modulation of antioxidants enzymes and glutathione status.

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Hepatic, renal and endogenous antioxidant status modulatory effects of chronic co-supplementation of rooibos (Aspalathus linearis) and red palm oil (Elaeis guineensis) in male Wistar rats

African Journal of Traditional Complementary and Alternative Medicines ◽

10.4314/ajtcam.v13i3.1 ◽

2016 ◽

Vol 13 (3) ◽

pp. 1 ◽

Cited By ~ 1

Author(s):

Olawale Razaq Ajuwon ◽

Oluwafemi Omoniyi Oguntibeju ◽

Jeanine Lucasta Marnewick

Keyword(s):

Palm Oil ◽

Antioxidant Status ◽

Wistar Rats ◽

Elaeis Guineensis ◽

Red Palm Oil ◽

Aspalathus Linearis ◽

Male Wistar Rats ◽

Endogenous Antioxidant

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Red Palm Oil Supplementation Does Not Increase Blood Glucose or Serum Lipids Levels in Wistar Rats With Different Thyroid Status

Physiological Research ◽

10.33549/physiolres.933834 ◽

2018 ◽

pp. 307-315 ◽

Cited By ~ 1

Author(s):

H. RAUCHOVÁ ◽

M. VOKURKOVÁ ◽

S. PAVELKA ◽

I. VANĚČKOVÁ ◽

N. TRIBULOVÁ ◽

...

Keyword(s):

Lipid Metabolism ◽

Blood Glucose ◽

Thyroid Hormones ◽

Palm Oil ◽

Wistar Rats ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Thyroid Status ◽

Red Palm Oil ◽

Glucose And Lipid Metabolism

Red palm oil (RPO) is a rich natural source of antioxidant vitamins, namely carotenes, tocopherols and tocotrienols. However, it contains approximately 50 % saturated fatty acids the regular consumption of which could negatively modify lipid profile. The aim of our study was to test whether 7 weeks of RPO supplementation (1 g/kg body weight/day) would affect blood glucose and lipid metabolism in adult male Wistar rats with altered thyroid status. We induced hypothyroidism and hyperthyroidism in rats by oral administration of either methimazole or mixture of thyroid hormones. Different thyroid status (EU – euthyroid, HY – hypothyroid and HT – hyperthyroid) was characterized by different serum thyroid hormones levels (total and free thyroxine and triiodothyronine), changes in the activity of a marker enzyme of thyroid status – liver mitochondrial glycerol-3-phosphate dehydrogenase, and altered absolute and relative heart weights. Fasting blood glucose levels were higher in HT rats in comparison with EU and HY rats, but the changes caused by RPO supplementation were not significant. The achievement of the HY status significantly increased serum levels of total cholesterol, as well as with high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol: 2.43±0.15, 1.48±0.09, 0.89±0.08 mmol/l, compared to EU: 1.14±0.06, 0.77±0.06, 0.34±0.05 mmol/l and HT: 1.01±0.06, 0.69±0.04, 0.20±0.03 mmol/l, respectively. RPO supplementation did not increase significantly levels of blood lipids but tended to increase glutathione levels in the liver. In conclusion, RPO supplementation did not induce the presumed deterioration of glucose and lipid metabolism in rats with three well-characterized alterations in thyroid status.

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