Sex-dependent gene expression of kidney transporters after Ochratoxin A exposure in F344 rats

2014 ◽  
Vol 229 ◽  
pp. S77
Author(s):  
Laura Pastor ◽  
Ariane Vettorazzi ◽  
Adela López de Cerain
Keyword(s):  
Gene Expression ◽  
Ochratoxin A ◽  
F344 Rats

Sex-dependent dose response of gene expression modulation after ochratoxin A insult in F344 rats

2017 ◽  
Vol 280 ◽  
pp. S88
Author(s):  
Ariane Vettorazzi ◽  
Laura Pastor ◽  
Adela López de Cerain
Keyword(s):  
Gene Expression ◽  
Ochratoxin A ◽  
Dose Response ◽  
Expression Modulation ◽  
F344 Rats

Ochratoxin A-induced renal gene expression changes in F344 rats after repeated oral administration

2007 ◽  
Vol 172 ◽  
pp. S189-S190
Author(s):  
Leire Arbillaga ◽  
Ariane Vettorazzi ◽  
Ana G. Gil ◽  
Adela López de Cerain
Keyword(s):  
Gene Expression ◽  
Oral Administration ◽  
Ochratoxin A ◽  
F344 Rats

scholarly journals Time Course of Renal Transcriptomics after Subchronic Exposure to Ochratoxin A in Fisher Rats

Toxins ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 177
Author(s):  
Laura Pastor ◽  
Ariane Vettorazzi ◽  
Elizabeth Guruceaga ◽  
López de Cerain A.
Keyword(s):  
Gene Expression ◽  
Ochratoxin A ◽  
Time Course ◽  
Early Response ◽  
Male Rats ◽  
Female Response ◽  
Metabolism Enzymes ◽  
F344 Rats ◽  
Expression Time ◽  
Over Time

The mycotoxin ochratoxin A (OTA) is a potent nephrocarcinogen, mainly in male rats. The aim of this study was to determine the time course of gene expression (GeneChip® Rat Gene 2.0 ST Array, Affymetrix) in kidney samples from male and female F344 rats, treated daily (p.o) with 0.50 mg/kg b.w. (body weight) of OTA for 7 or 21 days, and evaluate if there were differences between both sexes. After OTA treatment, there was an evolution of gene expression in the kidney over time, with more differentially expressed genes (DEG) at 21 days. The gene expression time course was different between sexes with respect to the number of DEG and the direction of expression (up or down): the female response was progressive and consistent over time, whereas males had a different early response with more DEG, most of them up-regulated. The statistically most significant DEG corresponded to metabolism enzymes (Akr1b7, Akr1c2, Adh6 down-regulated in females; Cyp2c11, Dhrs7, Cyp2d1, Cyp2d5 down-regulated in males) or transporters (Slc17a9 down-regulated in females; Slco1a1 (OATP-1) and Slc51b and Slc22a22 (OAT) down-regulated in males). Some of these genes had also a basal sex difference and were over-expressed in males or females with respect to the other sex.

Gene expression kinetics of renal transporters induced by ochratoxin A in male and female F344 rats

2016 ◽  
Vol 98 ◽  
pp. 169-178 ◽  
Author(s):  
Laura Pastor ◽  
Ariane Vettorazzi ◽  
Javier Campión ◽  
Paul Cordero ◽  
Adela López de Cerain
Keyword(s):  
Gene Expression ◽  
Ochratoxin A ◽  
Male And Female ◽  
Renal Transporters ◽  
Kinetics Of ◽  
F344 Rats ◽  
Expression Kinetics

In vitro gene expression data supporting a DNA non-reactive genotoxic mechanism for ochratoxin A

2007 ◽  
Vol 220 (2) ◽  
pp. 216-224 ◽  
Author(s):  
Leire Arbillaga ◽  
Amaia Azqueta ◽  
Joost H.M. van Delft ◽  
Adela López de Cerain
Keyword(s):  
Gene Expression ◽  
Ochratoxin A ◽  
Gene Expression Data ◽  
Expression Data

scholarly journals Microarray analysis of aging-associated immune system alterations in the rostral ventrolateral medulla of F344 rats

2017 ◽  
Vol 49 (8) ◽  
pp. 400-415 ◽  
Author(s):  
Sivasai Balivada ◽  
Chanran K. Ganta ◽  
Yongqing Zhang ◽  
Hitesh N. Pawar ◽  
Richard J. Ortiz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Immune System ◽  
Neural Substrates ◽  
Rostral Ventrolateral Medulla ◽  
Ventrolateral Medulla ◽  
Middle Aged ◽  
Transcriptomic Profile ◽  
Age Related ◽  
F344 Rats ◽  
Age Related Changes

The rostral ventrolateral medulla (RVLM) is an area of the brain stem that contains diverse neural substrates that are involved in systems critical for physiological function. There is evidence that aging affects some neural substrates within the RVLM, although age-related changes in RVLM molecular mechanisms are not well established. The goal of the present study was to characterize the transcriptomic profile of the aging RVLM and to test the hypothesis that aging is associated with altered gene expression in the RVLM, with an emphasis on immune system associated gene transcripts. RVLM tissue punches from young, middle-aged, and aged F344 rats were analyzed with Agilent’s whole rat genome microarray. The RVLM gene expression profile varied with age, and an association between chronological age and specific RVLM gene expression patterns was observed [ P < 0.05, false discovery rate (FDR) < 0.3]. Functional analysis of RVLM microarray data via gene ontology profiling and pathway analysis identified upregulation of genes associated with immune- and stress-related responses and downregulation of genes associated with lipid biosynthesis and neurotransmission in aged compared with middle-aged and young rats. Differentially expressed genes associated with the complement system and microglial cells were further validated by quantitative PCR with separate RVLM samples ( P < 0.05, FDR < 0.1). The present results have identified age-related changes in the transcriptomic profile of the RVLM, modifications that may provide the molecular backdrop for understanding age-dependent changes in physiological regulation.

scholarly journals Essential Oils Modulate Gene Expression and Ochratoxin A Production in Aspergillus carbonarius

Toxins ◽  
2016 ◽  
Vol 8 (8) ◽  
pp. 242 ◽  
Author(s):  
Rachelle El Khoury ◽  
Ali Atoui ◽  
Carol Verheecke ◽  
Richard Maroun ◽  
Andre El Khoury ◽  
...  
Keyword(s):  
Gene Expression ◽  
Essential Oils ◽  
Ochratoxin A ◽  
Aspergillus Carbonarius
Sign in / Sign up

Export Citation Format

Share Document