scholarly journals Transfusion of blood products derived from SARS-CoV-2+ donors to patients with hematological malignancies

2021 ◽  
pp. 103105
Author(s):  
Carlo Gambacorti-Passerini ◽  
Marco Ruggeri ◽  
Andrea Aroldi ◽  
Rocco Piazza ◽  
Angela Mazzi ◽  
...  
Keyword(s):  
Hematological Malignancies ◽  
Blood Products

GB Virus C/Hepatitis G Virus Isolates in Japanese Haemophiliacs and their Origins

1998 ◽  
Vol 80 (08) ◽  
pp. 242-245 ◽  
Author(s):  
Yoshihide Fukuda ◽  
Tetsuo Hayakawa ◽  
Junki Takamatsu ◽  
Hidehiko Saito ◽  
Hiroaki Okamoto ◽  
...  
Keyword(s):  
Sequence Similarity ◽  
West African ◽  
Blood Products ◽  
Hepatitis G Virus ◽  
Gb Virus C ◽  
Route Of Transmission ◽  
Polymerase Chain ◽  
Hepatitis G ◽  
Virus C ◽  
Virus Isolates

SummaryJapanese haemophiliacs have been at high risk for infection with parenterally-transmissible viruses through the use of blood products, especially imported ones. Recently, novel transfusion-transmissible virus, GB virus C (GBV-C)/hepatitis G virus (HGV) were isolated. We investigated the origin and route of transmission of GBV-C/HGV isolates in haemophiliacs in Japan. GBV-C/HGV RNA was measured by nested reverse transcription polymerase chain reaction in 91 Japanese haemophiliacs. Phylogenetic analysis and genotypic grouping of GBV-C/HGV isolates in Japanese haemophiliacs were performed based on sequences in the 5’ untranslated region, and the characteristics were compared with those of reported isolates. GBV-C/HGV infection was present in 19 of 91 haemophiliacs (20.9%). Sequence analysis showed that 15 of the 19 isolates (78.9%) showed sequence similarity to a group in which mainly West African isolates have been reported. The other 4 isolates (21.1%) showed sequence similarity to Asian isolates. None of the GBV-C/HGV isolates showed sequences similar to those generally found in isolates from USA and Europe. The majority of GBV-C/HGV isolates found in Japanese haemophiliacs who are considered to have been infected by imported blood products were similar to those detected in West Africa.

Bifunctional Role of Kruppel-Like Factor 4 in Hematological Malignancies

2016 ◽  
Vol 7 (1-2) ◽  
pp. 141-151
Author(s):  
Mario Morales-Martinez ◽  
Luz A. Franco-Cea ◽  
Liliana Moreno Vargas ◽  
Otoniel Martinez-Maza ◽  
Sara Huerta-Yepez ◽  
...  
Keyword(s):  
Hematological Malignancies
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