Kidney Transplant Recipients Show an Increase in the Ratio of T-Cell Effector Memory/Central Memory as Compared to Nontransplant Recipients on the Waiting List

2010 ◽  
Vol 42 (8) ◽  
pp. 2877-2879 ◽  
Author(s):  
D.S. Segundo ◽  
G. Fernández-Fresnedo ◽  
M. Gago ◽  
I. Beares ◽  
J. Ruiz-Criado ◽  
...  
Keyword(s):  
T Cell ◽  
Kidney Transplant ◽  
Central Memory ◽  
Waiting List ◽  
Effector Memory ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Cell Effector

scholarly journals Terminally Differentiated Effector Memory CD8+ T Cells Identify Kidney Transplant Recipients at High Risk of Graft Failure

2020 ◽  
Vol 31 (4) ◽  
pp. 876-891
Author(s):  
Lola Jacquemont ◽  
Gaëlle Tilly ◽  
Michelle Yap ◽  
Tra-My Doan-Ngoc ◽  
Richard Danger ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Kidney Transplant ◽  
Graft Failure ◽  
T Cell Subsets ◽  
Effector Memory ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Post Transplant ◽  
Transplant Failure

BackgroundIdentifying biomarkers to predict kidney transplant failure and to define new therapeutic targets requires more comprehensive understanding of the immune response to chronic allogeneic stimulation.MethodsWe investigated the frequency and function of CD8+ T cell subsets—including effector memory (EM) and terminally differentiated EM (TEMRA) CD8+ T cells—in blood samples from 284 kidney transplant recipients recruited 1 year post-transplant and followed for a median of 8.3 years. We also analyzed CD8+ T cell reactivity to donor-specific PBMCs in 24 patients who had received living-donor kidney transplants.ResultsIncreased frequency of circulating TEMRA CD8+ T cells at 1 year post-transplant associated with increased risk of graft failure during follow-up. This association remained after adjustment for a previously reported composite of eight clinical variables, the Kidney Transplant Failure Score. In contrast, increased frequency of EM CD8+ T cells associated with reduced risk of graft failure. A distinct TEMRA CD8+ T cell subpopulation was identified that was characterized by expression of FcγRIIIA (CD16) and by high levels of proinflammatory cytokine secretion and cytotoxic activity. Although donor-specific stimulation induced a similar rapid, early response in EM and TEMRA CD8+ T cells, CD16 engagement resulted in selective activation of TEMRA CD8+ T cells, which mediated antibody-dependent cytotoxicity.ConclusionsAt 1 year post-transplant, the composition of memory CD8+ T cell subsets in blood improved prediction of 8-year kidney transplant failure compared with a clinical-variables score alone. A subpopulation of TEMRA CD8+ T cells displays a novel dual mechanism of activation mediated by engagement of the T-cell receptor or of CD16. These findings suggest that TEMRA CD8+ T cells play a pivotal role in humoral and cellular rejection and reveal the potential value of memory CD8+ T cell monitoring for predicting risk of kidney transplant failure.

Clinical-Scale Rapid Autologous BK Virus-Specific T Cell Line Generation From Kidney Transplant Recipients With Active Viremia for Adoptive Immunotherapy

2017 ◽  
Vol 101 (11) ◽  
pp. 2713-2721 ◽  
Author(s):  
Caroline Lamarche ◽  
Julie Orio ◽  
Victoria Georges-Tobar ◽  
Thomas Pincez ◽  
Mathieu Goupil ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Line ◽  
Kidney Transplant ◽  
Adoptive Immunotherapy ◽  
Bk Virus ◽  
Clinical Scale ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Cell Line Generation ◽  
Line Generation

Impact of Anti–T-Cell Therapy in the Immunogenicity of Seasonal Influenza Vaccine in Kidney Transplant Recipients

2012 ◽  
Vol 94 (6) ◽  
pp. 630-636 ◽  
Author(s):  
Angela Orcurto ◽  
Manuel Pascual ◽  
Katja Hoschler ◽  
Vincent Aubert ◽  
Pascal Meylan ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Therapy ◽  
Influenza Vaccine ◽  
Kidney Transplant ◽  
Seasonal Influenza ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
T Cell Therapy ◽  
Seasonal Influenza Vaccine

scholarly journals CD4+T cell levels are decreased during active CMV infection in kidney transplant recipients

2002 ◽  
Vol 34 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Sahar Essa ◽  
Alexander S Pacsa ◽  
Raj Raghupathy ◽  
Raja'a Al-Attiyah ◽  
Amany El-Shazly ◽  
...  
Keyword(s):  
T Cell ◽  
Kidney Transplant ◽  
Cd4 T Cell ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Cmv Infection

scholarly journals Mortality in Elderly Waiting-List Patients Versus Age-Matched Kidney Transplant Recipients: Where is the Risk?

2018 ◽  
Vol 43 (1) ◽  
pp. 256-275 ◽  
Author(s):  
Domingo Hernández ◽  
Juana Alonso-Titos ◽  
Ana María Armas-Padrón ◽  
Pedro Ruiz-Esteban ◽  
Mercedes Cabello ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Waiting List ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Infection-Related Mortality in Recipients of a Kidney Transplant in Australia and New Zealand

2019 ◽  
Vol 14 (10) ◽  
pp. 1484-1492 ◽  
Author(s):  
Samuel Chan ◽  
Elaine M. Pascoe ◽  
Philip A. Clayton ◽  
Stephen P. McDonald ◽  
Wai H. Lim ◽  
...  
Keyword(s):  
New Zealand ◽  
T Cell ◽  
General Population ◽  
Kidney Transplant ◽  
Older Age ◽  
Competing Risk ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Female Sex ◽  
Related Mortality

Background and objectivesThe burden of infectious disease is high among kidney transplant recipients because of concomitant immunosuppression. In this study the incidence of infectious-related mortality and associated factors were evaluated.Design, setting, participants, & measurementsIn this registry-based retrospective, longitudinal cohort study, recipients of a first kidney transplant in Australia and New Zealand between 1997 and 2015 were included. Cumulative incidence of infectious-related mortality was estimated using competing risk regression (using noninfectious mortality as a competing risk event), and compared with age-matched, populated-based data using standardized incidence ratios.ResultsAmong 12,519 patients, (median age 46 years, 63% men, 15% diabetic, 6% Indigenous ethnicity), 2197 (18%) died, of whom 416 (19%) died from infection. The incidence of infection-related mortality during the study period (1997–2015) was 45.8 (95% confidence interval [95% CI], 41.6 to 50.4) per 10,000 patient-years. The incidence of infection-related mortality reduced from 53.1 (95% CI, 45.0 to 62.5) per 10,000 person-years in 1997–2000 to 43.9 (95% CI, 32.5 to 59.1) per 10,000 person-years in 2011–2015 (P<0.001) Compared with the age-matched general population, kidney transplant recipients had a markedly higher risk of infectious-related death (standardized incidence ratio, 7.8; 95% CI, 7.1 to 8.6). Infectious mortality was associated with older age (≥60 years adjusted subdistribution hazard ratio [SHR], 4.16; 95% CI, 2.15 to 8.05; reference 20–30 years), female sex (SHR, 1.62; 95% CI, 1.19 to 2.29), Indigenous ethnicity (SHR, 2.87; 95% CI, 1.84 to 4.46; reference white), earlier transplant era (2011–2015: SHR, 0.39; 95% CI, 0.20 to 0.76; reference 1997–2000), and use of T cell–depleting therapy (SHR, 2.43; 95% CI, 1.36 to 4.33). Live donor transplantation was associated with lower risk of infection-related mortality (SHR, 0.53; 95% CI, 0.37 to 0.76).ConclusionsInfection-related mortality in kidney transplant recipients is significantly higher than the general population, but has reduced over time. Risk factors include older age, female sex, Indigenous ethnicity, T cell–depleting therapy, and deceased donor transplantation.PodcastThis article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2019_08_27_CJN03200319.mp3

scholarly journals T-cell exhaustion correlates with improved outcomes in kidney transplant recipients

2019 ◽  
Vol 96 (2) ◽  
pp. 436-449 ◽  
Author(s):  
Miguel Fribourg ◽  
Lisa Anderson ◽  
Clara Fischman ◽  
Chiara Cantarelli ◽  
Laura Perin ◽  
...  
Keyword(s):  
T Cell ◽  
Kidney Transplant ◽  
T Cell Exhaustion ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Cell Exhaustion ◽  
Improved Outcomes

scholarly journals Waiting List and Kidney Transplant Vascular Risk: An Ongoing Unmet Concern

2019 ◽  
Vol 45 (1) ◽  
pp. 1-27 ◽  
Author(s):  
Domingo Hernández ◽  
Juana Alonso-Titos ◽  
Ana Maria Armas-Padrón ◽  
Veronica Lopez ◽  
Mercedes Cabello ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Kidney Transplant ◽  
Mineral Metabolism ◽  
Fibroblast Growth Factor 23 ◽  
Waiting List ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Pathogenic Mechanisms

Background: Chronic kidney disease (CKD) is an important independent risk factor for adverse cardiovascular events in patients waitlisted for kidney transplantation (KT). Although KT reduces cardiovascular risk, these patients still have a higher all-cause and cardiovascular mortality than the general population. This concerning situation is due to a high burden of traditional and nontraditional risk factors as well as uremia-related factors and transplant-specific factors, leading to 2 differentiated processes under the framework of CKD, atherosclerosis and arteriosclerosis. These can be initiated by insults to the vascular endothelial endothelium, leading to vascular calcification (VC) of the tunica media or the tunica intima, which may coexist. Several pathogenic mechanisms such as inflammation-related endothelial dysfunction, mineral metabolism disorders, activation of the renin-angiotensin system, reduction of nitric oxide, lipid disorders, and the fibroblast growth factor 23-klotho axis are involved in the pathogenesis of atherosclerosis and arteriosclerosis, including VC. Summary: This review focuses on the current understanding of atherosclerosis and arteriosclerosis, both in patients on the waiting list as well as in kidney transplant recipients, emphasizing the cardiovascular risk factors in both populations and the inflammation-related pathogenic mechanisms. Key Message: The importance of cardiovascular risk factors and the pathogenic mechanisms related to inflammation in patients waitlisted for KT and kidney transplant recipients.

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