scholarly journals Effects of Sugammadex Plus Rocuronium vs Neostigmine Plus Cisatracurium During Renal Transplantation on Graft Function: A Retrospective, Case-Control Study

2020 ◽  
Author(s):  
Maria Vargas ◽  
Pasquale Buonanno ◽  
Andrea Sica ◽  
Emanuele Sabatella ◽  
Francesco P. D’Alessio ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Case Control Study ◽  
Graft Function ◽  
Case Control ◽  
Retrospective Case ◽  
Control Study

scholarly journals Effects of sugammadex plus rocuronium vs neostigmine plus cisatracurium during renal transplantation on graft function.

2019 ◽  
Author(s):  
Maria Vargas ◽  
Pasquale Buonanno ◽  
Andrea Sica ◽  
Emanuele Sabatella ◽  
Francesco P. D’Alessio ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Medical Records ◽  
Case Control Study ◽  
Graft Function ◽  
Case Control ◽  
Retrospective Case ◽  
Blood Calcium ◽  
Urinary Potassium ◽  
Blood Potassium ◽  
Control Study

Abstract Background Rocuronium can be used in patients with severe renal failure (creatinine clearance <30 ml/min) but the duration of muscle relaxation is longer and results in an increased risk of postoperative residual curarization. Rocuronium can be antagonized by sugammadex but the elimination of the complex they made (rocuronium-sugammadex complex) varies according to the renal function. Two case reports/series reported the use of rocuronium – sugammadex complex during renal transplantation. This retrospective case-control study aimed to investigate the effects of rocuronium – sugammadex, used during the renal transplantation, on transplanted kidney function.Methods We analyzed 113 medical records of patients undergoing kidney transplantation from January 2015 to December 2018. 47 medical records were excluded because they did not report the administration of rocuronium + sugammadex or cisatracurium + neostigmine during the transplantation. For each medical records the following data were recorded the characteristics of patients and of kidney donor. Blood creatinine, blood urea, blood sodium, blood potassium, blood calcium levels were collected at the day before the surgery, the day of surgery, after 6 hours (hrs), 12 hrs, 24 hrs, 48 hrs and 72 hrs. Diuresis, urinary sodium and urinary potassium levels were collected at the day of surgery, after 6 hrs, 12 hrs, 24 hrs, 48 hrs and 72 hrs. Results We collected data from 66 medical reports. Blood creatinine levels at 6 hrs, 12 hrs and 24 hrs were significantly lower in roc + sug group than cis + neo group (crea 6 hrs =0.05, crea 12 hrs p=0.038, crea 24 hrs p= 0.049). Blood urea levels for 24 hrs after the transplantation were significantly lower in in roc + sug group than cis + neo group (urea 0 hrs p=0.025, urea 6 hrs p= 0.011, urea 12 hrs p=0.03, urea 24 hrs p=0.011). We found no statistically significant differences in blood sodium, blood potassium, blood calcium, diuresis, urinary sodium, urinary potassium levels before and after the transplantation.Conclusions In this retrospective case-control study, the use of rocuronium and sugammadex during the renal transplant surgery did not affect the recovery of the graft function during the first week after the transplantation.

scholarly journals Effects of sugammadex plus rocuronium vs neostigmine plus cisatracurium during renal transplantation on graft function: a retrospective, case-control study

2019 ◽  
Author(s):  
Maria Vargas ◽  
Pasquale Buonanno ◽  
Andrea Sica ◽  
Emanuele Sabatella ◽  
Francesco P. D’Alessio ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Medical Records ◽  
Case Control Study ◽  
Graft Function ◽  
Case Control ◽  
Retrospective Case ◽  
Blood Calcium ◽  
Transplanted Kidney ◽  
Urinary Potassium ◽  
Control Study

Abstract Background: Rocuronium can be used in patients with severe renal failure (creatinine clearance <30 ml/min), but the duration of muscle relaxation is longer and results in an increased risk of postoperative residual curarization. Rocuronium can be antagonized by sugammadex, but the elimination of the complex they make (rocuronium-sugammadex complex) varies according to the renal function. Two case reports/series have reported the use of rocuronium-sugammadex complex during renal transplantation. This retrospective case-control study aims to investigate the effects of rocuronium-sugammadex, used during renal transplantation, on transplanted kidney function. Methods: We analyzed 113 medical records of patients undergoing kidney transplantation from January 2015 to December 2018. Forty-seven medical records were excluded because they did not report the administration of rocuronium + sugammadex (roc + sug) or cisatracurium + neostigmine (cis + neo) during the transplantation. The demographics of patients and donors were collected along with the following data: blood urea and creatinine, serum and urinary electrolytes, and diuresis. Marginal, single or double kidney transplantations, Karpinsky score and histologic evaluation of transplanted kidney were collected. Results: We finally collected data from 66 medical reports from January 2015 to December 2018. Blood creatinine levels at 6 hrs, 12 hrs and 24 hrs were significantly lower in the roc + sug group than in the cis + neo group (crea 6 hrs =0.05, crea 12 hrs p=0.038, crea 24 hrs p= 0.049). Blood urea levels for 24 hrs after transplantation were significantly lower in the roc + sug group than in the cis + neo group (urea 0 hrs p=0.025, urea 6 hrs p= 0.011, urea 12 hrs p=0.03, urea 24 hrs p=0.011). We found no statistically significant differences in blood sodium, blood potassium, blood calcium, diuresis, urinary sodium, or urinary potassium levels before and after transplantation. Conclusions: In this retrospective case-control study, the use of rocuronium and sugammadex during renal transplant surgery did not affect the recovery of the graft function during the first week after transplantation.

Assessment of Craniofacial Morphology in Mouth Breathing Children. A retrospective case-control study

2019 ◽  
Vol 70 (10) ◽  
pp. 3649-3653
Author(s):  
David Angelescu ◽  
Teodora Angelescu ◽  
Meda Romana Simu ◽  
Alexandrina Muntean ◽  
Anca Stefania Mesaros ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Craniofacial Morphology ◽  
Respiratory Pattern ◽  
Control Group ◽  
Upper Lip ◽  
Retrospective Case ◽  
Oral Breathing ◽  
Facial Height ◽  
Control Study

The aim of this retrospective case-control study is to determine a possible correlation between breathing mode and craniofacial morphology. The study was carried out in the Department of Pedodontics,Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. The sample comprised 80 patients, age between 6 and 13 years, which were divided in two groups based on respiratory pattern: control group composed of 38 nasal breathing children and case group composed of 42 oral breathing children. Three quantitative craniofacial parameters were measured from the frontal and lateral photos: facial index, lower facial height ratio and upper lip ratio. The statistical analysis showed a significant higher facial index (p=0.006*) and an increase lower facial height (p=0.033*) for the oral breathers group. No differences in facial morphology were found between genders and age groups, when comparing the data between the same type of respiratory pattern children. Spearman�s rho Correlation show a significant positive correlation (p=0.002*) between facial index and lower facial height and a significant negative correlation between facial index and upper lip (p=0,005*). Long faces children are more likely to develop oral breathing in certain conditions, which subsequently have a negative effect on increasing the lower facial height by altering the postural behavior of mandible and tongue.

scholarly journals Prevalence of Balance Impairment and Factors Associated with Balance among Patients with Stroke. A Cross Sectional Retrospective Case Control Study

Healthcare ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 320
Author(s):  
Fayaz Khan ◽  
Mohamed Faisal Chevidikunnan
Keyword(s):  
Case Control Study ◽  
Binary Logistic Regression ◽  
Berg Balance Scale ◽  
Case Control ◽  
Knee Extensors ◽  
Retrospective Case ◽  
Cross Sectional ◽  
Balance Impairment ◽  
Factors Associated ◽  
Control Study

Stroke is a major cause of disability worldwide, and balance impairments are common disabling factors in patients with stroke, leading to falls. Thus, the study objectives were as follows: (i) To find the prevalence of balance impairment among patients with stroke. (ii) To find out the factors associated with balance impairment in patients with stroke. This cross-sectional retrospective case control study involved eighty-one post stroke patients with a mean age of 58.36 ± 14.06, recruited from six hospitals, who underwent an assessment of balance, walking speed, depression and isometric strength of the ankle and knee. These patients were later categorized into subjects with good balance (<45) in the Berg balance scale (BBS) and those with poor balance (≥45), as cases and controls, to assess the factors associated with balance impairment using binary logistic regression. The prevalence of balance impairment among patients with stroke was 48.1%. The reduction in power of knee flexors (OR = 0.858), knee extensors (OR = 0.880) and ankle dorsiflexors (OR = 0.820) was found to be significantly associated with balance impairment, along with speed (OR = 1.187 (95% CI = 1.100, 1.280)), depression (OR = 1.331 (95% CI = 1.055–1.679)) and activities of daily living (OR = 0.313 (95% CI = 0.150–0.650)). In summary, around half of the patients with stroke exhibited balance impairments, with females being more prone.

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