N-octanoyl dopamine ameliorates lung function in the acute phase after lung transplantation

Lymphangioleiomyomatosis is characterized by cystic destruction of the lungs due to abnormal proliferation of smooth muscle cells. It is caused by mutations of the genes encoding hamartin and tuberin, sometimes in association with tuberous sclerosis. CT imaging shows characteristic multiple thin-walled cysts. There is usually progressive airways obstruction and impaired gas diffusion, and two-thirds of patients suffer pneumothoraces. Sirolimus can stabilize lung function and improve symptoms. Patients should avoid exogenous oestrogens, including oestrogen contraceptives or hormonal replacement therapy. Pregnancy may be associated with an increased risk of pneumothorax and loss of lung function. Hormonal therapy with progesterone or tamoxifen appears to be ineffective: other antioestrogen therapies, such as letrozole, are being studied. Lung transplantation is the main option for advanced disease.

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Evidence of unilateral diaphragmatic paralysis on lung scintigraphy after double lung transplantation: impact on lung function and survival

Scandinavian Journal of Clinical and Laboratory Investigation ◽

10.1080/00365513.2020.1781244 ◽

2020 ◽

Vol 80 (6) ◽

pp. 454-455

Author(s):

Anna Warncke Kristensen ◽

Anders Møller Greve ◽

Rasmus H. Dahl ◽

Michael Perch ◽

Jann Mortensen ◽

...

Keyword(s):

Lung Function ◽

Lung Transplantation ◽

Diaphragmatic Paralysis ◽

Lung Scintigraphy

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Lung Function Decline in Cystic Fibrosis Patients and Timing for Lung Transplantation Referral

CHEST Journal ◽

10.1378/chest.126.2.412 ◽

2004 ◽

Vol 126 (2) ◽

pp. 412-419 ◽

Cited By ~ 104

Author(s):

Daniel B. Rosenbluth ◽

Kevin Wilson ◽

Thomas Ferkol ◽

Daniel P. Schuster

Keyword(s):

Cystic Fibrosis ◽

Lung Function ◽

Lung Transplantation ◽

Lung Function Decline

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Testing Lung Function Decline to Time Lung Transplantation

CHEST Journal ◽

10.1016/s0012-3692(15)37999-x ◽

2005 ◽

Vol 128 (1) ◽

pp. 472-473 ◽

Cited By ~ 2

Author(s):

Theodore G. Liou ◽

Frederick R. Adler ◽

Barbara C. Cahill

Keyword(s):

Lung Function ◽

Lung Transplantation ◽

Lung Function Decline

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Recurrent laryngeal nerve palsy following heart-lung transplantation: three cases of vocal cord augmentation in the acute phase

The Journal of Laryngology & Otology ◽

10.1017/s0022215100110643 ◽

1989 ◽

Vol 103 (10) ◽

pp. 968-969 ◽

Cited By ~ 10

Author(s):

G. E. Murty ◽

M. C. F. Smith

Keyword(s):

Lung Transplantation ◽

Recurrent Laryngeal Nerve ◽

Vocal Cord ◽

Acute Phase ◽

Nerve Palsy ◽

Recurrent Laryngeal Nerve Palsy ◽

Bronchial Tree ◽

Laryngeal Nerve ◽

Vocal Cord Dysfunction ◽

Laryngeal Nerve Palsy

AbstractThree cases of left recurrent laryngeal nerve palsy following heart-lung transplantation are described. In each case, within twelve hours of extubation, the left vocal cord was injected with Teflon, and the paralyzed vocal cord thus displaced to the midline. Effective closure of the glottis was then possible, permitting an adequate cough, adequate clearing of the bronchial tree and minimising the risk of aspiration. Augmentation under general anaesthesia as soon as possible after discovery of vocal cord dysfunction is advocated. Suitable materials for injection are discussed. To our knowledge, this is the first reported series of vocal cord augmentation in the acute phase following heart-lung transplantation.

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