Rhodococcus equi pneumonia in foals: An assessment of the early diagnostic value of serum amyloid A and plasma fibrinogen concentrations in equine clinical practice

2015 ◽  
Vol 203 (2) ◽  
pp. 211-218 ◽  
Author(s):  
F. Passamonti ◽  
D.M. Vardi ◽  
V. Stefanetti ◽  
M.L. Marenzoni ◽  
S. Prato ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Serum Amyloid A ◽  
Diagnostic Value ◽  
Rhodococcus Equi ◽  
Serum Amyloid ◽  
Plasma Fibrinogen ◽  
Amyloid A ◽  
Early Diagnostic

Study of serum amyloid A concentrations as a means of achieving early diagnosis of Rhodococcus equi pneumonia

2010 ◽  
Vol 37 (3) ◽  
pp. 212-216 ◽  
Author(s):  
N. D. COHEN ◽  
M. K. CHAFFIN ◽  
M. L. VANDENPLAS ◽  
R. F. EDWARDS ◽  
M. NEVILL ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Serum Amyloid A ◽  
Rhodococcus Equi ◽  
Serum Amyloid ◽  
Amyloid A

scholarly journals Can blood serum amyloid A concentrations in horses differentiate synovial sepsis from extrasynovial inflammation and determine response to treatment?

2020 ◽  
Vol 187 (6) ◽  
pp. 235-235
Author(s):  
Matthew Sinovich ◽  
Nicolas F Villarino ◽  
Ellen Singer ◽  
Claire S Robinson ◽  
Luis M Rubio-Martínez
Keyword(s):  
Serum Amyloid A ◽  
Prognostic Indicator ◽  
Diagnostic Value ◽  
Serum Amyloid ◽  
Response To Treatment ◽  
Specific Marker ◽  
Time Curve ◽  
Serial Blood ◽  
Amyloid A ◽  
Significant Difference

BackgroundSerum amyloid A (SAA) concentrations in blood and synovial fluid of horses with synovial sepsis have diagnostic value. Studies suggest serial blood SAA measurements could act as a prognostic indicator. This study evaluated the use of serial blood SAA concentrations for monitoring of horses with synovial sepsis.MethodsA prospective clinical trial was performed of horses referred to a single hospital with synovial sepsis that survived (n=17), synovial sepsis that were euthanised (n=5), non-septic intrasynovial pathologies (n=14) or extensive extrasynovial lacerations (n=5). SAA concentrations were determined on admission and every 24 hours thereafter. The area under the concentration–time curve from 0 to 144 hours of each group was compared by Kruskal-Wallis and post hoc Dunn’s tests (P<0.05).ResultsSignificant difference in mean blood concentration of SAA was found between synovial sepsis that survived and non-septic pathologies in the first 48 hours, as well as between non-septic intrasynovial pathologies and non-responsive sepsis requiring euthanasia. No difference was found between extensive extrasynovial lacerations and any septic group.ConclusionsWhile serial blood SAA is useful for monitoring clinical response of intrasynovial septic pathologies, interpretation should consider other clinical findings since blood SAA is not a specific marker for synovial sepsis.

Serum amyloid A and plasma fibrinogen concentrations in horses following emergency exploratory celiotomy

2019 ◽  
Vol 52 (1) ◽  
pp. 59-66 ◽  
Author(s):  
M. De Cozar ◽  
C. Sherlock ◽  
E. Knowles ◽  
T. Mair
Keyword(s):  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Plasma Fibrinogen ◽  
Amyloid A

Effects of ophthalmic disease on concentrations of plasma fibrinogen and serum amyloid A in the horse

2011 ◽  
Vol 43 (4) ◽  
pp. 460-465 ◽  
Author(s):  
A. L. LABELLE ◽  
R. E. HAMOR ◽  
A. L. MACNEILL ◽  
K. M. LASCOLA ◽  
C. B. BREAUX ◽  
...  
Keyword(s):  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Plasma Fibrinogen ◽  
Amyloid A ◽  
Ophthalmic Disease

Concentrations of serum amyloid A and plasma fibrinogen in horses undergoing emergency abdominal surgery

2015 ◽  
Vol 26 (3) ◽  
pp. 344-351 ◽  
Author(s):  
Alexander J. Daniel ◽  
Britta S. Leise ◽  
Brandy A. Burgess ◽  
Paul S. Morley ◽  
Madison Cloninger ◽  
...  
Keyword(s):  
Abdominal Surgery ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Plasma Fibrinogen ◽  
Amyloid A ◽  
Emergency Abdominal Surgery

scholarly journals Are serum amyloid A or D-lactate useful to diagnose synovial contamination or sepsis in horses?

2017 ◽  
Vol 181 (16) ◽  
pp. 425-425 ◽  
Author(s):  
Claire S Robinson ◽  
Ellen R Singer ◽  
Martina Piviani ◽  
Luis M Rubio-Martinez
Keyword(s):  
Synovial Fluid ◽  
Serum Amyloid A ◽  
Diagnostic Value ◽  
Case Control ◽  
Accurate Diagnosis ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Prompt Treatment ◽  
Life Threatening ◽  
And Control

Synovial sepsis in horses is life threatening and accurate diagnosis allowing prompt treatment is warranted. This study assessed the diagnostic value of serum amyloid A (SAA) and D-lactate in blood and synovial fluid (SF) as diagnostic markers of synovial sepsis in horses and correlated them with total nucleated cell count (TNCC), percentage of neutrophils (%N) and total protein (TP) in SF. Blood and SF SAA and D-lactate concentrations were determined in a case–control observational study including 112 horses (38 with synovial contamination or sepsis (SCS), 66 with non-septic intra-synovial pathology (NSISP) and 8 controls). Blood and SF SAA were significantly higher in SCS than in NSISP and control horses. SAA values were similar in NSISP and control horses. SF SAA was moderately correlated with synovial TNCC, TP and blood SAA. Blood and SF SAA were 82.4 per cent and 80 per cent sensitive and 88.9 per cent and 73 per cent specific for diagnosis of SCS, with cut-off values of 60.7 and 1.14 µg/ml, respectively. Blood and SF D-lactate concentrations were not significantly different between groups. This study shows that blood and SF SAA concentrations can aid to distinguish SCS from non-septic synovial pathology; however, D-lactate was not useful.

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