Effect of Dutasteride on Intraprostatic Androgen Levels in Men With Benign Prostatic Hyperplasia or Prostate Cancer

Abstract Background: Anogenital distance（AGD） can be used as a biomarker to indirectly indicate androgen levels during the sexual maturation of mammals. In order to gain a deeper understanding of the association between the AGD and the risk of prostate cancer(PCa), we performed this studyMaterials: A total of 107 patients undergoing perineal prostate biopsy from November 2019 to August 2020 were enrolled. All patients diagnosed 57 PCa patients and 50 benign prostatic hyperplasia(BPH) patients through perineal prostate biopsy in our hospital . The anus to the posterior base of the scrotum (AGDAS) and the cephalad insertion of the penis (AGDAP) of all patients were measured before prostate biopsy.Result: The mean age of patients with PCa was 69.46 ± 7.52 and the mean age of patients with BPH was 67.38± 8.26. We did not find a significant association between age and BMI in the risk of PCa(all p＞0.05). Besides, there was no significant association between AGD and the risk of PCa(p＞0.05). we only discovered that PSA could play an important role in the development of PCa.Conclusion: AGD may not play an important role in predicting the incidence risk of PCa. we still need a large-scale prospective study to explore the ture association between AGD and the incidence of PCa.

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468: Polymorphic CA Repeats in IGF-I Gene is a Common Genetic Modifier in the Etiology of Prostate Cancer and Benign Prostatic Hyperplasia

The Journal of Urology ◽

10.1016/s0022-5347(18)37730-9 ◽

2004 ◽

Vol 171 (4S) ◽

pp. 125-125

Author(s):

Lizhong Wang ◽

Kazunari Sato ◽

Norihiko Tsuchiya ◽

Chikara Ohyama ◽

Shigeru Satoh ◽

...

Keyword(s):

Prostate Cancer ◽

Benign Prostatic Hyperplasia ◽

Genetic Modifier ◽

Prostatic Hyperplasia ◽

Igf I ◽

I Gene

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Multiparametric MRI evaluation in benign prostatic hyperplasia – a true challenge in prostate cancer exclusion

Oncolog-Hematolog ro ◽

10.26416/onhe.49.4.2019.2740 ◽

2019 ◽

Vol 4 (49) ◽

pp. 23

Author(s):

Sandra O. Jurcă ◽

Gabriel Gluck ◽

Ioana G. Lupescu

Keyword(s):

Prostate Cancer ◽

Benign Prostatic Hyperplasia ◽

Multiparametric Mri ◽

Prostatic Hyperplasia ◽

Mri Evaluation

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Light-controlled calcium signalling in prostate cancer and benign prostatic hyperplasia

Future Journal of Pharmaceutical Sciences ◽

10.1186/s43094-020-00046-w ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

Vipin Sharma ◽

Rita Rana ◽

Ruma Baksi ◽

Swapnil P. Borse ◽

Manish Nivsarkar

Keyword(s):

Prostate Cancer ◽

Benign Prostatic Hyperplasia ◽

Calcium Signalling ◽

Prostatic Hyperplasia

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The Etiology and Pathophysiology Genesis of Benign Prostatic Hyperplasia and Prostate Cancer: A New Perspective

Medicines ◽

10.3390/medicines8060030 ◽

2021 ◽

Vol 8 (6) ◽

pp. 30

Author(s):

Teow J. Phua

Keyword(s):

Prostate Cancer ◽

Benign Prostatic Hyperplasia ◽

Cell Biology ◽

Cancer Biology ◽

Cost Savings ◽

Prostatic Hyperplasia ◽

Biological Processes ◽

New Perspective ◽

Prostatic Diseases

Background: The etiology of benign prostatic hyperplasia and prostate cancer are unknown, with ageing being the greatness risk factor. Methods: This new perspective evaluates the available interdisciplinary evidence regarding prostate ageing in terms of the cell biology of regulation and homeostasis, which could explain the timeline of evolutionary cancer biology as degenerative, inflammatory and neoplasm progressions in these multifactorial and heterogeneous prostatic diseases. Results: This prostate ageing degeneration hypothesis encompasses the testosterone-vascular-inflamm-ageing triad, along with the cell biology regulation of amyloidosis and autophagy within an evolutionary tumorigenesis microenvironment. Conclusions: An understanding of these biological processes of prostate ageing can provide potential strategies for early prevention and could contribute to maintaining quality of life for the ageing individual along with substantial medical cost savings.

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