scholarly journals Disabling complement regulatory activities of vaccinia virus complement control protein reduces vaccinia virus pathogenicity

Vaccine ◽  
2011 ◽  
Vol 29 (43) ◽  
pp. 7435-7443 ◽  
Author(s):  
John Bernet ◽  
Muzammil Ahmad ◽  
Jayati Mullick ◽  
Yogesh Panse ◽  
Akhilesh K. Singh ◽  
...  
Keyword(s):  
Vaccinia Virus ◽  
Complement Control Protein ◽  
Control Protein

scholarly journals Smallpox vaccines induce antibodies to the immunomodulatory, secreted vaccinia virus complement control protein

2009 ◽  
Vol 90 (11) ◽  
pp. 2604-2608 ◽  
Author(s):  
Joan E. Adamo ◽  
Clement A. Meseda ◽  
Jerry P. Weir ◽  
Michael J. Merchlinsky
Keyword(s):  
Vaccinia Virus ◽  
Humoral Response ◽  
Viral Proteins ◽  
Secreted Proteins ◽  
Complement Protein ◽  
Lethal Challenge ◽  
Complement Control Protein ◽  
Infected Cells ◽  
Control Protein ◽  
Primary Band

Vaccination with Dryvax elicits a broad humoral response against many viral proteins. Human vaccinia immune globulin was used to screen the secreted proteins from cells infected with Dryvax or the candidate smallpox vaccine LC16m8 to determine whether the protective humoral response included antibodies against secreted viral proteins. Many proteins were detected, with the primary band corresponding to a band of 28 or 30 kDa in cells infected with Dryvax or LC16m8, respectively. This was identified as the vaccinia virus complement protein (VCP), which migrated more slowly in LC16m8-infected cells due to post-translational glycosylation. Vaccinia virus deleted in VCP, vVCPko, protected mice from a lethal intranasal challenge of vaccinia Western Reserve strain. Mice vaccinated with purified VCP demonstrated a strong humoral response, but were not protected against a moderate lethal challenge of vaccinia virus, suggesting that the humoral response against VCP is not critical for protection.

Vaccinia virus complement control protein ameliorates hyperacute xenorejection by inhibiting xenoantibody binding

2002 ◽  
Vol 34 (8) ◽  
pp. 3277-3281 ◽  
Author(s):  
J.B Anderson ◽  
S.A Smith ◽  
R van Wijk ◽  
S Chien ◽  
G.J Kotwal
Keyword(s):  
Vaccinia Virus ◽  
Complement Control Protein ◽  
Control Protein

scholarly journals The Vaccinia Virus Complement Control Protein Modulates Adaptive Immune Responses during Infection

2010 ◽  
Vol 85 (6) ◽  
pp. 2547-2556 ◽  
Author(s):  
N. M. Girgis ◽  
B. C. DeHaven ◽  
Y. Xiao ◽  
E. Alexander ◽  
K. M. Viner ◽  
...  
Keyword(s):  
Immune Responses ◽  
Vaccinia Virus ◽  
Adaptive Immune Responses ◽  
Complement Control Protein ◽  
Adaptive Immune ◽  
Control Protein
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