scholarly journals Cross-protection to new drifted influenza A(H3) viruses and prevalence of protective antibodies to seasonal influenza, during 2014 in Portugal

Vaccine ◽  
2017 ◽  
Vol 35 (16) ◽  
pp. 2092-2099 ◽  
Author(s):  
Raquel Guiomar ◽  
Susana Pereira da Silva ◽  
Patrícia Conde ◽  
Paula Cristóvão ◽  
Ana Carina Maia ◽  
...  
Keyword(s):  
Influenza A ◽  
Seasonal Influenza ◽  
Cross Protection ◽  
Protective Antibodies

scholarly journals Reduced cross-protection against influenza A(H3N2) subgroup 3C.2a and 3C.3a viruses among Finnish healthcare workers vaccinated with 2013/14 seasonal influenza vaccine

2015 ◽  
Vol 20 (5) ◽  
Author(s):  
A Haveri ◽  
N Ikonen ◽  
I Julkunen ◽  
A Kantele ◽  
V J Anttila ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Northern Hemisphere ◽  
Healthcare Workers ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Cross Protection ◽  
Antibody Responses ◽  
Seasonal Influenza Vaccine ◽  
Virus Strains

Virus strains in the seasonal influenza vaccine for the 2014/15 northern hemisphere season remained unchanged from those in 2013/14. During spring 2014, drifted influenza A(H3N2) viruses, subgroup 3C.3a, were detected in Finland; another subgroup, 3C.2a, emerged in the 2014/15 season and has predominated. We monitored antibody responses against vaccine and epidemic strains (2013/14 and 2014/15) among Finnish healthcare workers after influenza vaccination with the 2013/14 vaccine. The data suggest reduced cross-protection towards both subgroups of drifted A(H3N2) viruses.

scholarly journals Evaluation of heterosubtypic cross-protection against highly pathogenic H5N1 by active infection with human seasonal influenza A virus or trivalent inactivated vaccine immunization in ferret models

2014 ◽  
Vol 95 (4) ◽  
pp. 793-798 ◽  
Author(s):  
Su-Jin Park ◽  
Eun-Ha Kim ◽  
Philippe Noriel Q. Pascua ◽  
Hyeok-Il Kwon ◽  
Gyo-Jin Lim ◽  
...  
Keyword(s):  
Influenza A ◽  
H5n1 Virus ◽  
Seasonal Influenza ◽  
Natural Infection ◽  
Cross Reactivity ◽  
Cross Protection ◽  
Highly Pathogenic ◽  
Hpai H5n1 ◽  
Group B ◽  
Group D

The threat of highly pathogenic avian influenza (HPAI) H5N1 viruses to cause the next pandemic remains a major concern. Here, we evaluated the cross-protection induced by natural infection of human seasonal influenza strains or immunization with trivalent inactivated influenza vaccine (TIV) against HPAI H5N1 (A/Vietnam/1203/2004) virus in ferrets. Groups were treated with PBS (group A), infected with H1N1 (group B) or H3N2 (group C) virus, or immunized with TIV (group D). Twelve weeks after the last treatment, serological assays revealed that groups B and C, but not group D, sustained moderate immunogenicity against homologous viruses; cross-reactivity against the H5N1 virus was not detected in any group. Following challenge with A/Vietnam/1203/2004 (H5N1) virus, only groups B and C exhibited attenuated viral loads leading to 100 % survival. Our data suggest that natural infection with human seasonal strains could potentially provide better heterosubtypic protection against HPAI H5N1 virus infection compared to TIV immunization.

scholarly journals Next generation methodology for updating HA vaccines against emerging human seasonal influenza A(H3N2) viruses

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
James D. Allen ◽  
Ted M. Ross
Keyword(s):  
Influenza Virus ◽  
Immune Responses ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Influenza Viruses ◽  
Next Generation ◽  
Virus Infections ◽  
Wild Type ◽  
Influenza Hemagglutinin ◽  
H3n2 Influenza

AbstractWhile vaccines remain the best tool for preventing influenza virus infections, they have demonstrated low to moderate effectiveness in recent years. Seasonal influenza vaccines typically consist of wild-type influenza A and B viruses that are limited in their ability to elicit protective immune responses against co-circulating influenza virus variant strains. Improved influenza virus vaccines need to elicit protective immune responses against multiple influenza virus drift variants within each season. Broadly reactive vaccine candidates potentially provide a solution to this problem, but their efficacy may begin to wane as influenza viruses naturally mutate through processes that mediates drift. Thus, it is necessary to develop a method that commercial vaccine manufacturers can use to update broadly reactive vaccine antigens to better protect against future and currently circulating viral variants. Building upon the COBRA technology, nine next-generation H3N2 influenza hemagglutinin (HA) vaccines were designed using a next generation algorithm and design methodology. These next-generation broadly reactive COBRA H3 HA vaccines were superior to wild-type HA vaccines at eliciting antibodies with high HAI activity against a panel of historical and co-circulating H3N2 influenza viruses isolated over the last 15 years, as well as the ability to neutralize future emerging H3N2 isolates.

A 75-year-old woman with seasonal influenza A (H3N2) virus infection and diarrhea

2010 ◽  
Vol 48 (4) ◽  
pp. 231-233 ◽  
Author(s):  
Martin C.W. Chan ◽  
Nelson Lee ◽  
Rity Y.K. Wong ◽  
Wing-Shan Ho ◽  
Joseph J.Y. Sung
Keyword(s):  
Virus Infection ◽  
Influenza A ◽  
Seasonal Influenza ◽  
H3n2 Virus

scholarly journals Incidence and Risk Factors of Pneumonia in Hospitalized Patients with Seasonal Influenza A or B

2017 ◽  
Vol 80 (4) ◽  
pp. 392 ◽  
Author(s):  
Seongjun Chu ◽  
Sang Joon Park ◽  
So My Koo ◽  
Yang Ki Kim ◽  
Ki Up Kim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Hospitalized Patients

scholarly journals Molecular Characterization of Seasonal Influenza A and B from Hospitalized Patients in Thailand in 2018–2019

Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 977
Author(s):  
Kobporn Boonnak ◽  
Chayasin Mansanguan ◽  
Dennis Schuerch ◽  
Usa Boonyuen ◽  
Hatairat Lerdsamran ◽  
...  
Keyword(s):  
Amino Acid ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Influenza Viruses ◽  
Surface Proteins ◽  
Antigenic Drift ◽  
Influenza B ◽  
Receptor Binding Site ◽  
Antigenic Sites ◽  
Ha Protein

Influenza viruses continue to be a major public health threat due to the possible emergence of more virulent influenza virus strains resulting from dynamic changes in virus adaptability, consequent of functional mutations and antigenic drift in surface proteins, especially hemagglutinin (HA) and neuraminidase (NA). In this study, we describe the genetic and evolutionary characteristics of H1N1, H3N2, and influenza B strains detected in severe cases of seasonal influenza in Thailand from 2018 to 2019. We genetically characterized seven A/H1N1 isolates, seven A/H3N2 isolates, and six influenza B isolates. Five of the seven A/H1N1 viruses were found to belong to clade 6B.1 and were antigenically similar to A/Switzerland/3330/2017 (H1N1), whereas two isolates belonged to clade 6B.1A1 and clustered with A/Brisbane/02/2018 (H1N1). Interestingly, we observed additional mutations at antigenic sites (S91R, S181T, T202I) as well as a unique mutation at a receptor binding site (S200P). Three-dimensional (3D) protein structure analysis of hemagglutinin protein reveals that this unique mutation may lead to the altered binding of the HA protein to a sialic acid receptor. A/H3N2 isolates were found to belong to clade 3C.2a2 and 3C.2a1b, clustering with A/Switzerland/8060/2017 (H3N2) and A/South Australia/34/2019 (H3N2), respectively. Amino acid sequence analysis revealed 10 mutations at antigenic sites including T144A/I, T151K, Q213R, S214P, T176K, D69N, Q277R, N137K, N187K, and E78K/G. All influenza B isolates in this study belong to the Victoria lineage. Five out of six isolates belong to clade 1A3-DEL, which relate closely to B/Washington/02/2009, with one isolate lacking the three amino acid deletion on the HA segment at position K162, N163, and D164. In comparison to the B/Colorado/06/2017, which is the representative of influenza B Victoria lineage vaccine strain, these substitutions include G129D, G133R, K136E, and V180R for HA protein. Importantly, the susceptibility to oseltamivir of influenza B isolates, but not A/H1N1 and A/H3N2 isolates, were reduced as assessed by the phenotypic assay. This study demonstrates the importance of monitoring genetic variation in influenza viruses regarding how acquired mutations could be associated with an improved adaptability for efficient transmission.

scholarly journals Complications Among Adults Hospitalized With Influenza: A Comparison of Seasonal Influenza and the 2009 H1N1 Pandemic

2014 ◽  
Vol 59 (2) ◽  
pp. 166-174 ◽  
Author(s):  
Carrie Reed ◽  
Sandra S. Chaves ◽  
Alejandro Perez ◽  
Tiffany D'Mello ◽  
Pamala Daily Kirley ◽  
...  
Keyword(s):  
Influenza A ◽  
Seasonal Influenza ◽  
H1n1 Pandemic ◽  
2009 H1n1

scholarly journals Roles of antibodies to influenza A virus hemagglutinin, neuraminidase, and M2e in conferring cross protection

2017 ◽  
Vol 493 (1) ◽  
pp. 393-398 ◽  
Author(s):  
Yu-Jin Kim ◽  
Eun-Ju Ko ◽  
Min-Chul Kim ◽  
Yu-Na Lee ◽  
Ki-Hye Kim ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Cross Protection
Sign in / Sign up

Export Citation Format

Share Document