Golden-star nanoparticles as adjuvant effectively promotes immune response to foot-and-mouth disease virus-like particles vaccine

Vaccine ◽  
2018 ◽  
Vol 36 (45) ◽  
pp. 6752-6760 ◽  
Author(s):  
Zhidong Teng ◽  
Shiqi Sun ◽  
Hao Chen ◽  
Jie Huang ◽  
Ping Du ◽  
...  
Keyword(s):  
Immune Response ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Virus Like Particles ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Biomineralization improves the thermostability of foot-and-mouth disease virus-like particles and the protective immune response induced

Nanoscale ◽  
2019 ◽  
Vol 11 (47) ◽  
pp. 22748-22761 ◽  
Author(s):  
Ping Du ◽  
Ronghuan Liu ◽  
Shiqi Sun ◽  
Hu Dong ◽  
Ruibo Zhao ◽  
...  
Keyword(s):  
Immune Response ◽  
Disease Virus ◽  
Immune Activation ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Protective Immune Response ◽  
Virus Like Particles ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Schematic description of immune activation of DCs of the thermostable biomineralized VLPs.

scholarly journals Chimeric RHDV Virus-Like Particles Displaying Foot-and-Mouth Disease Virus Epitopes Elicit Neutralizing Antibodies and Confer Partial Protection in Pigs

Vaccines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 470
Author(s):  
Giselle Rangel ◽  
Juan Bárcena ◽  
Noelia Moreno ◽  
Carlos P. Mata ◽  
José R. Castón ◽  
...  
Keyword(s):  
Immune Response ◽  
B Cell ◽  
Disease Virus ◽  
Cell Epitope ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Virus Like Particles ◽  
Chimeric Vlps ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Currently there is a clear trend towards the establishment of virus-like particles (VLPs) as a powerful tool for vaccine development. VLPs are tunable nanoparticles that can be engineered to be used as platforms for multimeric display of foreign antigens. We have previously reported that VLPs derived from rabbit hemorrhagic disease virus (RHDV) constitute an excellent vaccine vector, capable of inducing specific protective immune responses against inserted heterologous T-cytotoxic and B-cell epitopes. Here, we evaluate the ability of chimeric RHDV VLPs to elicit immune response and protection against Foot-and-Mouth disease virus (FMDV), one of the most devastating livestock diseases. For this purpose, we generated a set of chimeric VLPs containing two FMDV-derived epitopes: a neutralizing B-cell epitope (VP1 (140–158)) and a T-cell epitope [3A (21–35)]. The epitopes were inserted joined or individually at two different locations within the RHDV capsid protein. The immunogenicity and protection potential of the chimeric VLPs were analyzed in the mouse and pig models. Herein we show that the RHDV engineered VLPs displaying FMDV-derived epitopes elicit a robust neutralizing immune response in mice and pigs, affording partial clinical protection against an FMDV challenge in pigs.

scholarly journals Immunoreactivity and trypsin sensitivity of recombinant virus-like particles of foot-and-mouth disease virus

2015 ◽  
Vol 59 (01) ◽  
pp. 84-91 ◽  
Author(s):  
S. H. BASAGOUDANAVAR ◽  
M. HOSAMANI ◽  
R. P. TAMIL ◽  
B. P. SREENIVASA ◽  
B. K. CHANDRASEKHAR ◽  
...  
Keyword(s):  
Disease Virus ◽  
Recombinant Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Virus Like Particles ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Synthetic RNAs Mimicking Structural Domains in the Foot-and-Mouth Disease Virus Genome Elicit a Broad Innate Immune Response in Porcine Cells Triggered by RIG-I and TLR Activation

Viruses ◽  
2015 ◽  
Vol 7 (7) ◽  
pp. 3954-3973 ◽  
Author(s):  
Belén Borrego ◽  
Miguel Rodríguez-Pulido ◽  
Concepción Revilla ◽  
Belén Álvarez ◽  
Francisco Sobrino ◽  
...  
Keyword(s):  
Immune Response ◽  
Disease Virus ◽  
Innate Immune Response ◽  
Foot And Mouth Disease ◽  
Virus Genome ◽  
Mouth Disease ◽  
Innate Immune ◽  
Structural Domains ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Selective Lymphocyte Depletion during the Early Stage of the Immune Response to Foot-and-Mouth Disease Virus Infection in Swine

2006 ◽  
Vol 80 (5) ◽  
pp. 2369-2379 ◽  
Author(s):  
Fayna Díaz-San Segundo ◽  
Francisco J. Salguero ◽  
Ana de Avila ◽  
M. Mar Fernández de Marco ◽  
Miguel A. Sánchez-Martín ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Disease Virus ◽  
Ex Vivo ◽  
Early Stage ◽  
Foot And Mouth Disease ◽  
Analytical Techniques ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth

ABSTRACT Foot-and-mouth disease virus (FMDV) is the causative agent of a highly contagious vesicular disease of cloven-hoofed animals. In the present study we use FMDV serotype C infection of swine to determine, by analytical techniques, the direct ex vivo visualization of virus-infected immune cells during the first 17 days of infection. We report, for the first time, that FMDV C-S8c1 can infect T and B cells at short periods of time postinoculation, corresponding with the peak of the viremia. There is a significant lymphopenia that involves CD3+ CD4− CD8+/−, CD3+ CD4− CD8+Tc, and CD3+ CD4+ CD8+ memory Th but not CD3+ CD4+ CD8− naïve Th lymphocytes. In addition, a profound depletion of the vast majority of peripheral T cells in lymph nodes and spleen is observed. This selective depletion of T cells is not due mainly to in situ death via apoptosis as visualized by the terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL) technique. Thus, early infection of T cells by FMDV may be the main cause of the observed T-cell depletion. Importantly, this lack of T cells is reflected in a reduced response to mitogen activation, which in many cases is totally eliminated. These data suggest a mechanism by which the virus causes a transient immunosuppression, subvert the immune systems, and spreads. These results have important implications for our understanding of early events in the development of a robust immune response against FMDV.

Immune response of calves to foot-and-mouth disease virus vaccine emulsified with oil adjuvant. Strategies of vaccination

Vaccine ◽  
1995 ◽  
Vol 13 (10) ◽  
pp. 909-914 ◽  
Author(s):  
E.J.A. Späth ◽  
E. Smitsaart ◽  
A.P.E. Casaro ◽  
N. Fondevila ◽  
F. Fernández ◽  
...  
Keyword(s):  
Immune Response ◽  
Disease Virus ◽  
Virus Vaccine ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth
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