International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease

Streptococcus pneumoniae serotype 12F rarely colonizes the nasopharynx but commonly causes invasive pneumococcal disease. Here, we report the complete genome sequence of a sequence type 4846 (ST4846) S. pneumoniae serotype 12F strain isolated from a cluster of invasive pneumococcal disease patients in Japan.

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Clonal Spread of mef-Positive Macrolide-Resistant Streptococcus pneumoniae Isolates Causing Invasive Disease in Adults in Germany

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.01453-06 ◽

2007 ◽

Vol 51 (5) ◽

pp. 1830-1834 ◽

Cited By ~ 8

Author(s):

Mark van der Linden ◽

Adnan Al-Lahham ◽

Stefan Haupts ◽

Ralf René Reinert

Keyword(s):

Streptococcus Pneumoniae ◽

Invasive Pneumococcal Disease ◽

Pneumococcal Disease ◽

Invasive Disease ◽

Sequence Type ◽

Macrolide Resistance ◽

Erythromycin A ◽

Clonal Spread ◽

Sequence Types

ABSTRACT Isolates (3,845) obtained from German adults with invasive pneumococcal disease between 1992 and 2004 were investigated. Of these, 430 isolates (11.2%) were erythromycin A nonsusceptible. Macrolide resistance genotypes and multilocus sequence types were determined. Among the isolates, 35.6% were erm(B) positive and 63.5% were mef positive. Over the study period, the frequency of resistance rose significantly from 2.2 to 17.0% (P < 0.001). A serotype 14, sequence type 9 clone was the most widespread.

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Molecular characterization of an Australian serotype 1Streptococcus pneumoniaeoutbreak

Epidemiology and Infection ◽

10.1017/s0950268814000648 ◽

2014 ◽

Vol 143 (2) ◽

pp. 325-333 ◽

Cited By ~ 8

Author(s):

M. STAPLES ◽

R. M. A. GRAHAM ◽

A. V. JENNISON ◽

L. ARIOTTI ◽

V. HICKS ◽

...

Keyword(s):

Streptococcus Pneumoniae ◽

Molecular Characterization ◽

Invasive Pneumococcal Disease ◽

Pneumococcal Disease ◽

Clonal Expansion ◽

Sequence Type ◽

Healthy Adults ◽

Mlva Type ◽

Serotype 1

SUMMARYSerotype 1Streptococcus pneumoniaeis a cause of invasive pneumococcal disease (IPD) worldwide and has been associated with IPD outbreaks, while carriage is rarely detected in healthy adults or children. This study details an Australian multi-state and territory outbreak of serotype 1S. pneumoniaeIPD between 2010 and 2012. Molecular characterization demonstrated the outbreak was largely due to the clonal expansion of sequence type 306, MLVA type 261S. pneumoniaeserotype 1.

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STREPTOCOCCUS PNEUMONIAE (SPN) SEROTYPES AND ANTIMICROBIAL RESISTANCE: BEGINNING OF THE NATIONAL SURVEILLANCE PROGRAM IN ADULTS WITH INVASIVE PNEUMOCOCCAL DISEASE (IPD) IN ARGENTINA.

10.26226/morressier.5731f0d2d462b8029237ffbc ◽

2016 ◽

Author(s):

Omar Enrique Veliz

Keyword(s):

Streptococcus Pneumoniae ◽

Antimicrobial Resistance ◽

Invasive Pneumococcal Disease ◽

Pneumococcal Disease ◽

Surveillance Program ◽

National Surveillance

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Serotype Childhood Invasive Pneumococcal Disease has Unique Characteristics Compared to Disease Caused by Other Streptococcus pneumoniae Serotypes

The Pediatric Infectious Disease Journal ◽

10.1097/inf.0b013e31829f2c72 ◽

2013 ◽

Vol 32 (7) ◽

pp. e313

Author(s):

&NA;

Keyword(s):

Streptococcus Pneumoniae ◽

Invasive Pneumococcal Disease ◽

Pneumococcal Disease

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Evaluating post-vaccine expansion patterns of pneumococcal serotypes

10.1101/2020.05.31.20116228 ◽

2020 ◽

Author(s):

Maile T. Phillips ◽

Joshua L. Warren ◽

Noga Givon-Lavi ◽

Adrienn Tothpal ◽

Gili Regev-Yochay ◽

...

Keyword(s):

Streptococcus Pneumoniae ◽

Invasive Pneumococcal Disease ◽

Jewish Population ◽

Pneumococcal Disease ◽

Pneumococcal Serotypes ◽

Conjugate Vaccines ◽

Pneumococcal Conjugate Vaccines ◽

Vaccine Serotypes ◽

Serotype Replacement ◽

Disease Understanding

ABSTRACTStreptococcus pneumoniae remains a leading cause of morbidity and mortality. Pneumococcal conjugate vaccines (PCVs) are effective but target only a fraction of the more than 90 pneumococcal serotypes. As a result, the introduction of PCVs has been followed by the emergence of non-vaccine serotypes. With higher-valency PCVs currently under development, there is a need to understand and predict patterns of serotype replacement to anticipate future changes. In this study, we evaluated patterns of change in serotype prevalence post-PCV introduction in Israel. We found that the assumption that non-vaccine serotypes increase by the same proportion overestimates changes in serotype prevalence in Jewish and Bedouin children. Furthermore, pre-vaccine prevalence was positively associated with increases in prevalence over the study period. From our analyses, serotypes 12F, 8, 16F, 33F, 9N, 7B, 10A, 22F, 24F, and 17F were estimated to have gained the most cases of invasive pneumococcal disease through serotype replacement in the Jewish population. However, this model also failed to quantify some additional cases gained, suggesting that changes in carriage in children alone may be insufficient to explain serotype replacement in disease. Understanding of serotype replacement is important as higher-valency vaccines are introduced.

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Invasive isolates of Streptococcus pneumoniae in Serbia: Antimicrobial susceptibility and serotypes

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh1302048g ◽

2013 ◽

Vol 141 (1-2) ◽

pp. 48-53 ◽

Cited By ~ 2

Author(s):

Ina Gajic ◽

Vera Mijac ◽

Lazar Ranin ◽

Dragana Andjelkovic ◽

Miroslava Radicevic ◽

...

Keyword(s):

Streptococcus Pneumoniae ◽

Invasive Pneumococcal Disease ◽

Antimicrobial Susceptibility ◽

Pneumococcal Disease ◽

Medical Problem ◽

Resistance Rate ◽

Reference Laboratory ◽

Susceptibility Pattern ◽

Antimicrobial Susceptibility Pattern ◽

Resistance Rates

Introduction. Streptococcus pneumoniae is one of the leading causes of bacterial meningitis and sepsis. Invasive pneumococcal disease is a significant medical problem worldwide, particularly in children, due to a huge increase of pneumococcal resistance to antibiotics. Objective. The aim of the study was to investigate the antimicrobial susceptibility pattern of invasive pneumococcal isolates, as well as to determine whether decreased S. pneumoniae susceptibility to antibiotics was related to a particular serotype. Methods. Antimicrobial susceptibility to 19 antibiotics was determined in 58 invasive pneumococcal strains that were collected from seven regional centers during the period July 2009 to February 2011 in the National Reference Laboratory for streptococci and pneumococci. Results. The overall nonsusceptibility rate to penicillin was detected in 34% of pneumococcal isolates and to erythromycin in 36%. Higher resistance rates were observed among children than among adults. Penicillin resistance rate was 65% in children versus 22% in adults, while erythromycin nonsusceptibility rate was 47% in children versus 32% in adults. Co-resistance to penicillin and erythromycin was detected in 21% strains, mostly isolated from children. Multiresistance was found in one third of isolates. All strains were susceptible to vancomycin, linezolid, fluoroquinolones, telithromycin and rifampicin, while 23 (40%) isolates were susceptible to all tested antibiotics. The most common resistant serotypes were 19F and 14. Conclusion. The study has revealed that penicillin and macrolide resistance among invasive pneumococcal isolates is very high in Serbia. This emphasizes the need for continuous monitoring for invasive pneumococcal disease to document the serotype distribution and antimicrobial susceptibility pattern.

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Serotype Distribution of Streptococcus pneumoniae causing Invasive Pneumococcal Disease at Bambino Gesù Children's Hospital in Rome: Is It Time for a New Vaccine?

Journal of Pediatric Infectious Diseases ◽

10.1055/s-0037-1615784 ◽

2018 ◽

Vol 14 (01) ◽

pp. 013-015

Author(s):

Elena Bozzola ◽

Andrzej Krzysztofiak ◽

Annausa Pantosti ◽

Laura Lancella ◽

Paola Bernaschi ◽

...

Keyword(s):

Streptococcus Pneumoniae ◽

Invasive Pneumococcal Disease ◽

Pneumococcal Disease ◽

Pediatric Age ◽

Immunization Programs ◽

Serotype Distribution ◽

Conjugate Vaccines ◽

Pneumococcal Conjugate Vaccines ◽

Children's Hospital ◽

The Impact

AbstractDiseases caused by Streptococcus pneumoniae are mostly preventable infections by current immunization programs. The objective of this study was to evaluate the impact of the introduction of the heptavalent and the 13-valent pneumococcal conjugate vaccines (PCV7 and PCV13) on the burden of pneumococcal disease and on the serotype distribution of S. pneumoniae causing invasive pneumococcal diseases (IPDs) in the pediatric age over a 5-year study (from January 2008 till December 2012). We observed a decrease in IPD rate in children after PCV13 introduction despite increases in nonvaccine serotype (NVS) rates in 2011. Nevertheless, from 2012, an increase in IPD rates due to non-PCV13 serotypes was observed.

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