The antagonist activity of lipid IVa on the stimulation by lipid A of TNF-alpha production from canine blood mononuclear cells

2011 ◽  
Vol 143 (1-2) ◽  
pp. 167-169
Author(s):  
Kenji Takasawa ◽  
Rui Kano ◽  
Haruhiko Maruyama ◽  
Atsuhiko Hasegawa ◽  
Hiroshi Kamata
Keyword(s):  
Lipid A ◽  
Mononuclear Cells ◽  
Tnf Alpha ◽  
Antagonist Activity ◽  
Alpha Production ◽  
Blood Mononuclear Cells

scholarly journals Ricin induces the production of tumour necrosis factor-α and interleukin-1 β by human peripheral-blood mononuclear cells

1993 ◽  
Vol 294 (2) ◽  
pp. 517-520 ◽  
Author(s):  
F Licastro ◽  
M C Morini ◽  
A Bolognesi ◽  
F Stirpe
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Tumour Necrosis ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Interleukin 1 ◽  
Tnf Alpha ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Necrosis Factor

Ricin induced the release of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta by human peripheral-blood mononuclear cells in a dose- and time-dependent manner. The inhibition induced by ricin upon the phytohaemagglutinin (PHA)-driven lymphocyte proliferation was greater in cultures of mononuclear cells than that observed in monocyte-free cultures of lymphocytes, and was decreased after addition of an anti-TNF-alpha antibody to PHA-activated cultures. Low levels of TNF-alpha were detected in plasma from rats poisoned with ricin. These results suggest that ricin induced the release of macrophage-derived cytokines which may have a role in the pathogenesis of ricin toxic effects.

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