RNA-seq analysis of murine peyer’s patches at 6 and 18 h post infection with Fasciola hepatica metacecariae

2021 ◽  
pp. 109643
Author(s):  
K. Connick ◽  
R. Lalor ◽  
A. Murphy ◽  
A. Glasgow ◽  
C. Breen ◽  
...  
Keyword(s):  
Post Infection ◽  
Fasciola Hepatica ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Rna Seq

scholarly journals Enhanced Protection Against Influenza Virus Infection with Dispersion Controlled Lactic Acid Bacteria Powder

2020 ◽  
Author(s):  
Takumi Watanabe ◽  
Kyoko Hayashi ◽  
Isao Takahashi ◽  
Makoto Ohwaki ◽  
Tatsuhiko Kan ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Virus Infection ◽  
Post Infection ◽  
Influenza Virus Infection ◽  
Peyer's Patches ◽  
Infection Model ◽  
Peyer’S Patches ◽  
Water Dispersibility

We evaluated the change in water dispersibility of lactic acid bacteria (LAB, Enterococcus faecalis KH2) upon powderization and its influence on their efficacy. When cultured LAB are washed, heat-killed, and powdered, adhesion between LAB occurs and they form aggregation (non-treated LAB, n-LAB). However, a dispersed LAB (d-LAB) powder with less aggregates can be prepared by treating them with a high-pressure homogenizer and adding an excipient during powdering. n-LAB or d-LAB was administered to mice and the Peyer's patches in the small intestine were observed. n-LAB administration showed a high amount of aggregated LAB drifting in the intestinal mucosa, whereas d-LAB reached the Peyer's patches and was taken up into the Peyer's patches. Evaluation in a mouse influenza virus infection model showed that d-LAB was more effective than n-LAB in influenza yield of bronchoalveolar lavage fluids (BALFs) on day 3 post-infection, neutralizing antibody titers of sera and influenza virus-specific IgA in the feces on day 14 post-infection. Thus, the physical properties of LAB affect their efficacy; controlling their water dispersibility can improve their effectiveness.

scholarly journals Physical properties of lactic acid bacteria influence the level of protection against influenza infection in mice

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251784
Author(s):  
Takumi Watanabe ◽  
Kyoko Hayashi ◽  
Isao Takahashi ◽  
Makoto Ohwaki ◽  
Tatsuhiko Kan ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Physical Properties ◽  
Post Infection ◽  
Influenza Virus Infection ◽  
Peyer's Patches ◽  
Infection Model ◽  
Peyer’S Patches ◽  
Water Dispersibility

We evaluated whether the water dispersibility of lactic acid bacteria (Enterococcus faecalis KH2) affects their efficacy. When cultured lactic acid bacteria are washed, heat-killed, and powdered, adhesion occurs between results in aggregation (non-treated lactic acid bacteria, n-LAB). However, dispersed lactic acid bacteria (d-LAB) with a lower number of aggregates can be prepared by treating them with a high-pressure homogenizer and adding an excipient during powdering. Mice were administered n-LAB or d-LAB Peyer’s patches in the small intestine were observed. Following n-LAB administration, a high amount of aggregated bacteria drifting in the intestinal mucosa was observed; meanwhile, d-LAB reached the Peyer’s patches and was absorbed into them. Evaluation in a mouse influenza virus infection model showed that d-LAB was more effective than n-LAB in the influenza yield of bronchoalveolar lavage fluids on day 3 post-infection and neutralizing antibody titers of sera and influenza virus-specific immunoglobulin A in the feces on day 14 post-infection. Therefore, the physical properties of lactic acid bacteria affect their efficacy; controlling their water dispersibility can improve their effectiveness.

Post-mortem Peyer’s patches: Their potential application in forensic medicine

2009 ◽  
Vol 00 (00) ◽  
pp. 090513010017019-7
Author(s):  
Biagio Solarino ◽  
Giancarlo Di Vella ◽  
Thea Magrone ◽  
Felicita Jirillo ◽  
Angela Tafaro ◽  
...  
Keyword(s):  
Forensic Medicine ◽  
Potential Application ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Post Mortem

scholarly journals Fibroblastic reticular cell lineage convergence in Peyer’s patches governs intestinal immunity

2021 ◽  
Vol 22 (4) ◽  
pp. 510-519
Author(s):  
Alejandro Prados ◽  
Lucas Onder ◽  
Hung-Wei Cheng ◽  
Urs Mörbe ◽  
Mechthild Lütge ◽  
...  
Keyword(s):  
Cell Lineage ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Reticular Cell ◽  
Intestinal Immunity ◽  
Fibroblastic Reticular Cell

scholarly journals HMGB1 promotes CXCL12‐dependent egress of murine B cells from Peyer's patches in homeostasis

2021 ◽  
Author(s):  
Lorenzo Spagnuolo ◽  
Viola Puddinu ◽  
Noémie Boss ◽  
Thibaud Spinetti ◽  
Anne Oberson ◽  
...  
Keyword(s):  
B Cells ◽  
Peyer's Patches ◽  
Peyer’S Patches

scholarly journals Effect of TU‐100 on Peyer's patches in a bacterial translocation rat model

2021 ◽  
Author(s):  
Chie Takasu ◽  
Katsuki Miyazaki ◽  
Kozo Yoshikawa ◽  
Masaaki Nishi ◽  
Takuya Tokunaga ◽  
...  
Keyword(s):  
Bacterial Translocation ◽  
Rat Model ◽  
Peyer's Patches ◽  
Peyer’S Patches

scholarly journals Whipple’s Disease Affecting Ileal Peyer’s Patches: The First Case Report

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Sabah Sid’Amar ◽  
Giacomo Puppa
Keyword(s):  
Lymphoid Tissue ◽  
Diagnostic Yield ◽  
Clinical Investigation ◽  
Periodic Acid ◽  
Disease Diagnosis ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Whipple’S Disease ◽  
Whipple's Disease ◽  
First Case

Whipple’s disease is a rare chronic systemic bacterial infectious disease which can affect multiple organs, with a wide clinical spectrum encompassing many symptoms presenting in various forms and combinations. In the cases where the gastrointestinal tract is implicated, the more frequent localizations involve the small bowel, especially the duodenum. A case of a 67-year-old man who underwent clinical investigation after presenting with a progressive weight loss and showing a hypercapting right paracoeliac adenopathy at PET-CT scan is reported herein. A gastroscopy and a colonoscopy were done. The biopsies of the endoscopically normal ileal mucosa encompassed some submucosal Peyer’s patches. Histological examination of this lymphoid tissue revealed several foamy macrophages which turned out positive on periodic acid-Schiff special staining. Polymerase chain reaction of the microdissected lymph follicles allowed for confirming Whipple’s disease diagnosis. A targeted antibiotic treatment administrated to the patient led to a rapid clinical improvement. This finding of a previously unreported localization of infected macrophages in Whipple’s disease suggests that sampling the organized mucosal-submucosal lymphoid tissue may increase the diagnostic yield in endoscopic biopsies.

Sign in / Sign up

Export Citation Format

Share Document