Identification of in vivo interaction between Hepatitis C Virus core protein and 5′ and 3′ UTR RNA

2009 ◽  
Vol 145 (2) ◽  
pp. 285-292 ◽  
Author(s):  
Kyung Lee Yu ◽  
Soo In Jang ◽  
Ji Chang You
2000 ◽  
Vol 74 (4) ◽  
pp. 1736-1741 ◽  
Author(s):  
Hiroshi Aoki ◽  
Junpei Hayashi ◽  
Mitsuhiko Moriyama ◽  
Yasuyuki Arakawa ◽  
Okio Hino

ABSTRACT Persistent hepatitis C virus (HCV) infection is a major cause of chronic liver dysfunction in humans and is epidemiologically closely associated with the development of human hepatocellular carcinoma. Among HCV components, core protein has been reported to be implicated in cell growth regulation both in vitro and in vivo, although mechanisms explaining those effects are still unclear. In the present study, we identified that members of the 14-3-3 protein family associate with HCV core protein. 14-3-3 protein bound to HCV core protein in a phosphoserine-dependent manner. Introduction of HCV core protein caused a substantial increase in Raf-1 kinase activity in HepG2 cells and in a yeast genetic assay. Furthermore, the HCV core–14-3-3 interaction was essential for Raf-1 kinase activation by HCV core protein. These results suggest that HCV core protein may represent a novel type of Raf-1 kinase-activating protein through its interaction with 14-3-3 protein and may contribute to hepatocyte growth regulation.


2001 ◽  
Vol 8 (6) ◽  
pp. 492-503 ◽  
Author(s):  
Kun-Lin Chen ◽  
Chun-Ming Chen ◽  
Chwen-Ming Shih ◽  
Huey-Lan Huang ◽  
Yan-Hwa Wu Lee ◽  
...  

1994 ◽  
Vol 68 (6) ◽  
pp. 3631-3641 ◽  
Author(s):  
E Santolini ◽  
G Migliaccio ◽  
N La Monica

Author(s):  
Rin Yamaguchi ◽  
Seiya Momosaki ◽  
Guang Gao ◽  
Chu Hsia ◽  
Masamichi Kojiro ◽  
...  

1995 ◽  
Vol 2 (1) ◽  
pp. 9-17 ◽  
Author(s):  
Z. Chen ◽  
I. Berkower ◽  
R. Y.-H. Wang ◽  
W.-M. Ching ◽  
H. J. Alter ◽  
...  

1993 ◽  
Vol 18 (1) ◽  
pp. 138-139 ◽  
Author(s):  
Yuko Taura ◽  
Shigetoshi Fujiyama ◽  
Shin-ichi Kawano ◽  
Shinjiro Sato ◽  
Masafumi Goto ◽  
...  

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